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52 (0,083s) •

Project

Intermittent androgen blockade abd androgen receptor mutation (NR7798)

Mechanism why intermittent androgen blockade selects androgen receptor. Whether androgen receptor mutations are responsible for progression to hormonally escaped tumourwill be examined. Changes of androgen receptor...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 478 tis. Kč
    • •
  • 398 tis. Kč
    • •
  • MZ
Project

New prognostic markers and epigenetic characterization of prostate cancer (NR9475)

Annotation I: The study of ligand independent regulation of the androgen receptor. Annotation II: Clarify the role of corepressors in ligand independent regulation of androgen receptor. Annotation III: Clarify the role of histone de...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 2 320 tis. Kč
    • •
  • 2 189 tis. Kč
    • •
  • MZ
Project

Mechanisms involved in epigenetic control of expression and function of androgen receptor (AR) in prostate cancer Potential therapeutic implications of AR coactivators blockade. (NS10262)

1/ Regulation of mechanism by which corepressors compete with coactivators for binding to androgen receptor. 2/ Elucidate an effect of the inhibitor histone of androgen receptor silencing, we would like to test the effect of demethy...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 2 340 tis. Kč
    • •
  • 2 222 tis. Kč
    • •
  • MZ
Project

The relationship of the androgen receptor gene mutations and changes in the androgen receptor expression in prostate cancer to the biological properties of the tumor and to the hormonal profile (NR8096)

The project is focused on the determination of the relationship of the androgen receptor gene mutations and changes in the AR expression in localized prostate cancer to the histopathological properties of the tumour and to the androgen

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 3 119 tis. Kč
    • •
  • 3 110 tis. Kč
    • •
  • MZ
Project

Polymorphism of the androgen receptor gene (SNP rs6152) relationship to expression of the androgen-sensitive genes in benign prostatic hyperplasia, carcinoma of the prostate and androgenetic (NS9940)

of androgen receptordependent disorders such as BPH, CaP and AGA. Changes in expression of investigated androgen sensitive genes (PCA3, KLK7/11) could make diagnosis of earlier CaP......

FD - Onkologie a hematologie

  • 2008 - 2011
    • •
  • 4 883 tis. Kč
    • •
  • 4 510 tis. Kč
    • •
  • MZ
Project

The role of episterosterone in pathogenesis of androgen-dependent diseases (NB4846)

The aim of the project is elucidation of the role of epitestosterone as an endogenous antiandrogen in pathogenesis of some androgen-dependentn endocrine diseases associated with a disbalance of sex steroid hormones.......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1998 - 2000
    • •
  • 3 870 tis. Kč
    • •
  • 2 821 tis. Kč
    • •
  • MZ
Project

In vitro bioassay of endocrine disruptors agonists and antagonists of estrogens and androgens (1QS500450557)

The environmental agonists and antagonists of estrogens and androgens are hypothesized to disrupt normal endocrine function leading to reduced fertility, congenital-/androgen-responsive tissue. U.S and E.U. authorities have suggeste...

EH - Ekologie – společenstva

  • 2005 - 2007
    • •
  • 900 tis. Kč
    • •
  • 900 tis. Kč
    • •
  • AV ČR
Project

The role of environmental pollutants in mechanisms regulating development of prostate carcinoma (GA310/07/0961)

Molecular etiology of prostate cancer, and especially of advanced androgen of cellular subpopulations and acquired androgen independency present a major of androgen-independent subpopulations). Special attention will be pai...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2007 - 2010
    • •
  • 9 024 tis. Kč
    • •
  • 9 024 tis. Kč
    • •
  • GA ČR
Project

Experimental model for treatment of androgen-dependent diseases of the prostate. (IZ1432)

9F - 9

  • 1993 - 1995
    • •
  • 237 tis. Kč
    • •
  • 474 tis. Kč
    • •
  • MZ
Project

A study of the relationship between c-erbB-2 and the androgen-independence markers in prostate cancer diagnostic and predictive aspects (NC7497)

, on the expression of c-erbB-2 and ozher markers involved in the control of androgen-dependence...

FD - Onkologie a hematologie

  • 2003 - 2005
    • •
  • 3 512 tis. Kč
    • •
  • 3 150 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 52