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147 (0,045s) •

Project

Structure-activity guided design of novel long-acting antagonists of muscarinic receptors (GA23-04670S)

disorders. Antagonists with long-residence time at receptors are acting longer which novel class of antagonists are PAM-antagonists that exert positive cooperativity with endogenous neurotransmitter. PAM-antagonists

Pharmacology and pharmacy

  • 2023 - 2025
    • •
  • 11 518 tis. Kč
    • •
  • 11 371 tis. Kč
    • •
  • GA ČR
Project

The effects of histamine receptor H4R antagonists on the production of reactive oxygen and nitrogen metabolites by phagocytes (LD11010)

of histamine receptors: H1R, H2R, H3R, and H4R. While H1R, H2R and H3R antagonists are widely used in the treatment of allergy and other diseases, antagonists of the newly on haemopoietic cells including phagocytes. Whereas the eff...

EC - Imunologie

  • 2011 - 2013
    • •
  • 1 506 tis. Kč
    • •
  • 1 506 tis. Kč
    • •
  • MŠMT
Project

Tumor targeted prodrugs of glutamine antagonists (LTAUSA18166)

Synthesis of prodrugs of glutamine antagonist 6-diazo-5-oxo-L-norleucine with specific ability to release the parent drug in target cancer cells by the action of enzymes overexpressed in cancer tissues. Pharmacokinetic studies of synthesized...

Organic chemistry

  • 2019 - 2022
    • •
  • 8 040 tis. Kč
    • •
  • 6 368 tis. Kč
    • •
  • MŠMT
Project

Dietary monoterpenoids as a novel class of aryl hydrocarbon receptor negative allosteric modulators in the therapy of colon cancer (GA23-04662S)

antagonists have been proposed as therapeutic strategy for viral diseases such as Zika and Covid19, and pancreatic cancer. Existing antagonists are ligand-dependent and of limited clinical use. However, ligand-independent AhR a...

Biochemistry and molecular biology

  • 2023 - 2025
    • •
  • 7 926 tis. Kč
    • •
  • 7 926 tis. Kč
    • •
  • GA ČR
Project

The effect of non-peptide angiotensin II receptor antagonist on experimental ischemic renal injury (IZ4174)

The study follows the aim to survey possibilities of pharmacological influence on renal ischemic injury in rats by means of non-peptide angiotensin II receptor antagonist and to try to find an optimum schema for its use within clinical exper...

FJ - Chirurgie včetně transplantologie

  • 1997 - 1999
    • •
  • 2 127 tis. Kč
    • •
  • 1 823 tis. Kč
    • •
  • MZ
Project

The determination of the baroreflex gain in non-treateg hypertensives and hypertensives treated with ACE-inhibitors and Ca-antagonists. (IZ4313)

The purpose is to study baroreflex mediated response of blood pressure (BP) on the non-invasive step change of BP (10-20 mmHg) in patients with essential hypertension without therapy and trated with ACE inhibitors and Ca antagonists.......

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 1997 - 1999
    • •
  • 828 tis. Kč
    • •
  • 668 tis. Kč
    • •
  • MZ
Project

Radioprotective effects of calcium antagonists usedalone or with cytokines (ROVLA50000060)

BO - Biofyzika

  • 1994 - 1995
    • •
  • 250 tis. Kč
    • •
  • 500 tis. Kč
    • •
  • MO
Project

Insect hormones, theirs analogs and antagonists in the development and reproduction of insects (GA522/02/1458)

The aim of the project is to study the influence of insect hormones, their analogues and antagonists on development and fecundity of selected insect species. The mechanism of action of the above mentioned compounds will be studied in Spodopt...

EA - Morfologické obory a cytologie

  • 2002 - 2004
    • •
  • 3 261 tis. Kč
    • •
  • 1 686 tis. Kč
    • •
  • GA ČR
Project

Selection of Antagonistic Bacteria Useful in the Control of Frost Injury (GA513/94/1520)

9B - 9

  • 1994 - 1996
    • •
  • 348 tis. Kč
    • •
  • 530 tis. Kč
    • •
  • GA ČR
Project

Mode of action of cytokinin signalling antagonists in the cadmium stress - prevention of uptake or increased sequestration? (GP14-07418P)

the cytokinins can be induced also by chemical way using a cytokinin antagonist. The aim of this project is to study the effect of such antagonists on plant growth in the presence......

EF - Botanika

  • 2014 - 2018
    • •
  • 1 821 tis. Kč
    • •
  • 1 821 tis. Kč
    • •
  • GA ČR
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