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20 (0,113s) •

Project

Anthelmintics in plants – uptake, biotransformation and transcriptional response (GA15-05325S)

Anthelmintics, the drugs against parasitic worms, are widely used in human persist in the environment and impact non-target organisms. Moreover, anthelmintics of anthelmintics in plants is missing, present project is design...

CE - Biochemie

  • 2015 - 2017
    • •
  • 5 418 tis. Kč
    • •
  • 5 418 tis. Kč
    • •
  • GA ČR
Project

UDP-glycosyltransferases in Haemonchus contortus –players in drug-resistance? (GJ17-11954Y)

of parasite resistance to commonly used anthelmintics has dramatically increased, a better understanding of resistance mechanisms is vital. Effective detoxification of anthelmintics-glycosyltransferases (UGTs) plays an essential ro...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2017 - 2021
    • •
  • 4 336 tis. Kč
    • •
  • 4 336 tis. Kč
    • •
  • GA ČR
Project

Anthelmintics in plants – interactions with polyphenols biosynthesis and antioxidant defence (GA18-08452S)

Veterinary anthelmintics, widely used drugs against parasitic worms, represent anthelmintics and that glycosidation is the main pathway. Glycosidation is also. This project will be focused on the interaction of plants with anthe...

Pharmacology and pharmacy

  • 2018 - 2021
    • •
  • 6 281 tis. Kč
    • •
  • 6 281 tis. Kč
    • •
  • GA ČR
Project

Drug-resistance development in helminths - possible mechanisms and defense (GAP502/10/0217)

and human, to common anthelmintics represents a worldwide problem. Therefore, the study the study of metabolism of important anthelmintics and DME in selected helminth development. Comprehensive information on anthelmintics

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2010 - 2014
    • •
  • 7 135 tis. Kč
    • •
  • 7 135 tis. Kč
    • •
  • GA ČR
Project

Dicrocoeliosis in farm animals - defence mechanisms of lancet fluke against anthelmintics (GA524/07/0611)

effects of anthelmintics. Biotransformation enzymes of fluke can deactivate, the increase of biotransformation enzymes activities could contribute to anthelmintic resistance. We shall study the metabolism of anthelmintics ...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2007 - 2009
    • •
  • 1 785 tis. Kč
    • •
  • 1 785 tis. Kč
    • •
  • GA ČR
Project

Benzimidazole anthelmintics and induction of biotransformation enzymes in food-producing animals (GA524/03/1361)

Benzimidazole anthelmintics (albendazole, fenbendazole, thiabendazole, mebendazole, flubendazole etc.) belong among the most frequently applied medical drugs that administration of benzimidazole anthelmintics to food-producing anima...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2003 - 2005
    • •
  • 2 977 tis. Kč
    • •
  • 2 412 tis. Kč
    • •
  • GA ČR
Project

Circulation of anthelmintics in the environment - does it contribute to drug resistance development in parasitic nematodes? (GA18-07724S)

the fate of anthelmintics in environment and their metabolism in plants. In new project, we will study the changes induced by contact of nematodes with anthelmintics with excrements of treated animals. We would like to know if the ...

Pharmacology and pharmacy

  • 2018 - 2021
    • •
  • 6 145 tis. Kč
    • •
  • 6 145 tis. Kč
    • •
  • GA ČR
Project

Biotransformation enzymes of ruminants and their parasites - significance for therapy of parasitoses and anthelmintic resistance. (GA524/06/1345)

are able to reduce lot of xenobiotics including some anthelmintics. In this project we of anthelmintic efficacy against Haemonchus contortus in sheep (Ovis aries). The aims in parasite Haemonchus contortus and in its host - sheep t...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2006 - 2008
    • •
  • 2 928 tis. Kč
    • •
  • 2 928 tis. Kč
    • •
  • GA ČR
Project

Anthelmintic resistance in parasitic helminths of farm animals in Czech republic (PG98540)

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GJ - Choroby a škůdci zvířat, veterinární medicina

  • 1998 - 1998
    • •
  • 113 tis. Kč
    • •
  • 75 tis. Kč
    • •
  • MŠMT
Project

High-throughput screening for new anthelmintics (LTC19030)

is the identification of novel structural classes of anthelmintics by the means of high-throughput of the established anthelmintics and has been used for the studies of the resistance mechanisms......

Microbiology

  • 2019 - 2021
    • •
  • 2 543 tis. Kč
    • •
  • 2 543 tis. Kč
    • •
  • MŠMT
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