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Projects

24 projects (0,231s) •

Project

Anthracycline cardiotoxicity – new possibilities of pharmacological cardioprotection and risks of combination with biological targeted anticancer treatment (NT13457)

to reduce risks of anthracycline cardiotoxicity, although data from complex experimental cardiomyocytes. Furthermore, potential interference with anticancer effects of anthracyclines of anthracyclines with some novel targe...

FR - Farmakologie a lékárnická chemie

  • 2012 - 2015
    • •
  • 6 320 tis. Kč
    • •
  • 6 320 tis. Kč
    • •
  • MZ
Project

Chemical biology approach to study anthracycline cardiotoxicity and pharmacological cardioprotection with focus on topoisomerase II beta (GA21-16195S)

Anthracyclines (e.g., doxorubicin, daunorubicin) rank among the important anticancer drugs, but their usefulness is limited by risk of toxic myocardial injury and heart failure development. In recent years there have been paradigm shift from...

Pharmacology and pharmacy

  • 2021 - 2023
    • •
  • 10 035 tis. Kč
    • •
  • 10 035 tis. Kč
    • •
  • GA ČR
Project

Study of protective effects of novel iron chelators in the heart injury induced by oxidative stress and anthracycline cytostatics (GP305/05/P156)

by anthracycline cytostatics. The main purpose of this project is to study the possible caused by oxidative stress and anthracyclines will be investigated. In selected......

FR - Farmakologie a lékárnická chemie

  • 2005 - 2007
    • •
  • 1 184 tis. Kč
    • •
  • 1 184 tis. Kč
    • •
  • GA ČR
Project

Roles of oxidative stress and antioxidative systems in antracycline induced chronic cardiotoxicity in adult patients. (NS9774)

Aim of this study is to evaluate the role of oxidative stress ( level of oxidative stress, major antioxidative enzymes´ activity, gene polymorphisms for major antioxidative enzymes ) in anthracycline induced chronic cardiotoxicity in the cli...

FD - Onkologie a hematologie

  • 2008 - 2011
    • •
  • 5 397 tis. Kč
    • •
  • 5 163 tis. Kč
    • •
  • MZ
Project

Unique isoform-selective topoisomerase II inhibitors as a tool for effective and safe anticancer therapy (LUAUS24335)

anthracycline cardiotoxicity is the catalytic topoisomerase II (TOP2) inhibitor dexrazoxane of anthracyclines. The project investigators have succeeded in obtaining a unique selective in vivo against chronic anthracycline ...

Organic chemistry

  • 2024 - 2027
    • •
  • 11 512 tis. Kč
    • •
  • 11 512 tis. Kč
    • •
  • MŠMT
Project

Correlation of Hear-2/neu and TOP2A status with clinical response of advanced breast cancer patients to anthracykline based chemotherapy (NC7506)

to anthracyclines in patients with advanced breast cancer. We believe, that the proposed study anthracycline based chemotherapy in breast cancer patients.......

FD - Onkologie a hematologie

  • 2003 - 2005
    • •
  • 2 326 tis. Kč
    • •
  • 2 326 tis. Kč
    • •
  • MZ
Project

Automonous circulations functions,myocard and cardiorespiratory functions in children and adolescents after malignancy treatment. (NR8006)

Patients treated during childhood for malignancy with cardiotoxical anthracycline treatment are risk group for development of cardiovascular diseases in adulthood. Frequence of anthracycline cardiotoxicity is connected with total do...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 1 378 tis. Kč
    • •
  • 1 365 tis. Kč
    • •
  • MZ
Project

Effect of polyphenols and chelators on toxicity and effects of anthracyclines and taxanes (NL7567)

of apoptosis by anthracyclines and mechanisms of apoptosis induction related to p53...

FR - Farmakologie a lékárnická chemie

  • 2003 - 2005
    • •
  • 5 395 tis. Kč
    • •
  • 2 443 tis. Kč
    • •
  • MZ
Project

Anthracycline-induced DNA damage signaling in the heart implications for cardiotoxicity development and its pharmacological modulations (GA23-06558S)

Cardiotoxicity and heart failure caused by anthracycline anticancer drugs (ANTs, e.g., doxorubicin or daunorubicin) have been recently linked to topoisomerase II beta (TOP2B)-induced DNA damage in the heart. However, the mechanistic role of ...

Pharmacology and pharmacy

  • 2023 - 2025
    • •
  • 9 981 tis. Kč
    • •
  • 9 810 tis. Kč
    • •
  • GA ČR
Project

Study of individual topoisomerase II isoforms in anticancer and cardiotoxic effects of anthracyclines and their modulations by bisdioxopiperazines (GA18-08169S)

to anthracyclines and/or catalytic TOP2 ihibitors, synthesis and in vitro and in vivo...

Pharmacology and pharmacy

  • 2018 - 2020
    • •
  • 9 622 tis. Kč
    • •
  • 9 622 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 24