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8 (0,103s) •

Project

Diagnosis of proarrhythmic effect of antiarrhythmic drugs. (IZ2948)

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 1995 - 1997
    • •
  • 826 tis. Kč
    • •
  • 758 tis. Kč
    • •
  • MZ
Project

Prospective randomized double-blind study of efficacy and safety of 1c class antiarrhythmic agent (propafenone) for supraventricular arrhythmias in septic shock (NV18-06-00417)

Arrhythmias accompany septic shock and their presence is related to patient´s prognosis. 1C class antiarrhythmics are seldom administered in intensive care due to an alleged dose-dependent toxicity published in case reports and unfavourable ...

Cardiac and Cardiovascular systems

  • 2018 - 2023
    • •
  • 8 403 tis. Kč
    • •
  • 8 234 tis. Kč
    • •
  • MZ
Project

Testing of the Anti-Arrhythmic Effects of Potential Drugs From The Group of Ultra-short-Acting Blockers of Adrenergic Receptors (NR9126)

Antiarrhytmic agents from the beta blocker group have the lowest arrhytmogenic effect and are thus most requested in the clinical practice. The compounds that we are testing belong to the group of ultra-short acting beta adrenergic receptor blockers....

FR - Farmakologie a lékárnická chemie

  • 2006 - 2008
    • •
  • 1 165 tis. Kč
    • •
  • 1 165 tis. Kč
    • •
  • MZ
Project

Molecular genetic aspects of proarrhythmic of non-antiarrhythmic drugs. (NA7424)

QT interval prolongation and increased risk of sudden death are adverse effects of long list of widely used drugs. The fenomenon has been called the acquired long QT syndrome and its mechanism remains unclear. The congenital long QT syndrome is under...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2003 - 2005
    • •
  • 2 324 tis. Kč
    • •
  • 2 119 tis. Kč
    • •
  • MZ
Project

Catheter Ablation vs. Risk Factor Modification (NU21-02-00388)

ablation over antiarrhythmic drugs (AADs). Recent non-randomized observational studies...

Cardiac and Cardiovascular systems

  • 2021 - 2025
    • •
  • 18 744 tis. Kč
    • •
  • 13 237 tis. Kč
    • •
  • MZ
Project

Determination of the basic pharmacodynamic and pharmacokinetic parameters of newly synthesized ultrashort-acting betalytics (GA305/06/0863)

The project's objective lies in the determination of the pharmacodyn. and pharmacokin. parameters of the potentially perspective newly synthesised substances. The compounds are originals that have been made by the Dept. of Chem.Drugs at the PF of the...

FR - Farmakologie a lékárnická chemie

  • 2006 - 2008
    • •
  • 1 013 tis. Kč
    • •
  • 1 013 tis. Kč
    • •
  • GA ČR
Project

Sequential Hybrid Ablation versus Surgical CryoMaze Alone for Treatment of Atrial Fibrillation (SurHyb Trial) a multicenter randomized controlled trial (NV19-02-00046)

centers. The primary outcome is AF-free survival off antiarrhythmic drugs, which...

Cardiac and Cardiovascular systems

  • 2019 - 2023
    • •
  • 25 259 tis. Kč
    • •
  • 15 504 tis. Kč
    • •
  • MZ
Project

Titin-truncating variants as a cause of cardiomyopathy in humans genotype-phenotype correlations and predictors of disease severity (NW25J-02-00024)

, pregnancy counselling, and an early indication of implant antiarrhythmic device...

Cardiac and Cardiovascular systems

  • 2025 - 2028
    • •
  • 6 996 tis. Kč
    • •
  • 6 996 tis. Kč
    • •
  • MZ
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