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15 (0,193s) •

Project

The role of gabaergic system in anxyolytic an anticonvulsant effects of benzoidazepines (GA305/99/1481)

efficacious anticonvulsants ever discovered. The neurobiological mechanism of their anxiolytic and anticonvulsive effects is not well understood, however. Which that the anxiolytic and anticonvulsive effects of benzodiazep...

FR - Farmakologie a lékárnická chemie

  • 1999 - 2001
    • •
  • 2 855 tis. Kč
    • •
  • 2 516 tis. Kč
    • •
  • GA ČR
Project

Anticonvulsant profile of drugs facilitating gabaergic inhibition. (IZ4036)

FH - Neurologie, neurochirurgie, neurovědy

  • 1997 - 1997
    • •
  • 215 tis. Kč
    • •
  • 215 tis. Kč
    • •
  • MZ
Project

Treatment rezistant depression and diagnostic possibilities of indication for anticonvulsant therapy (NR8824)

treatment rezistant patients on anticonvulsant treatment and to develop a practical...

FH - Neurologie, neurochirurgie, neurovědy

  • 2006 - 2009
    • •
  • 2 011 tis. Kč
    • •
  • 2 011 tis. Kč
    • •
  • MZ
Project

Augmentation of GABAergic Inhibition As a Mechanism of Anticonvulsant Action in Developing Brain. (IZ2668)

FL - Psychiatrie, sexuologie

  • 1995 - 1997
    • •
  • 943 tis. Kč
    • •
  • 900 tis. Kč
    • •
  • MZ
Project

Synthesis and evaluation of neurosteroids as possible antiepileptics (IBS5011007)

New types of compounds, capable of binding to the steroid site of GABA-A receptor supramolecular complex, will be synthesized. Anticonvulsant action of these compounds will be tested against motor seizures induced by pentylenetetrazol in adu...

CC - Organická chemie

  • 2000 - 2004
    • •
  • 4 397 tis. Kč
    • •
  • 2 085 tis. Kč
    • •
  • AV ČR
Project

Effects of drugs influencing metabotropic glutamate receptors in immature laboratory rats (GA305/06/1188)

to have anticonvulsant, anxiolytic, antinociceptive and possible neuroprotective and two models of pain will be used to study anticonvulsant and antinociceptive......

FR - Farmakologie a lékárnická chemie

  • 2006 - 2008
    • •
  • 3 806 tis. Kč
    • •
  • 3 806 tis. Kč
    • •
  • GA ČR
Project

Drugs influencing GABA-B receptors in pediatric medicine (GAP304/10/1274)

Present project will be focused on the role of GABA-B receptors in seizures, pain, anxiety and withdrawal signs in immature rats. Anticonvulsant action of a positive modulator and an agonist will be studied in a model of cortical and hippoca...

FH - Neurologie, neurochirurgie, neurovědy

  • 2010 - 2012
    • •
  • 4 034 tis. Kč
    • •
  • 4 034 tis. Kč
    • •
  • GA ČR
Project

Synergistic interactions of analgesics with neuropsychotrophic drugs (NL7317)

The principal aim of the project is to find a combination of analgesics with neuropsychotropis drugs which would have significantly greater analgesic effect than the analgesic components alone (in equivalent doses). Major reason for this project is t...

FH - Neurologie, neurochirurgie, neurovědy

  • 2002 - 2004
    • •
  • 995 tis. Kč
    • •
  • 993 tis. Kč
    • •
  • MZ
Project

Centre for neuropsychiatric research of the traumatic stress (1M06039)

of anticonvulsant treatment in psychiatry. From the research as well as clinical point of view...

FL - Psychiatrie, sexuologie

  • 2006 - 2011
    • •
  • 39 486 tis. Kč
    • •
  • 35 537 tis. Kč
    • •
  • MŠMT
Project

Development of the effective drug delivery system intended for application in organophosphate poisoning for intranasal administration (FW09020121)

and anticonvulsant) intranasally • to determinate biodistribution, pharmacokinetics and drug...

Pharmacology and pharmacy

  • 2023 - 2027
    • •
  • 11 780 tis. Kč
    • •
  • 7 643 tis. Kč
    • •
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