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Modelling of potentially antimycobacterial active compounds (1A8238)
agents that have better or a unique mechanism of action, different from the currently antimycobacterial, antifungal, resp. cytoxicity evaluation is the aim of the project. Complete described series of novel prospective antitubercul...
FR - Farmakologie a lékárnická chemie
- 2004 - 2006 •
- 1 651 tis. Kč •
- 1 646 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2004 - 1. 1. 2006
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Novel antifungally active conjugates of poly(ethylene glycol)s (GA203/06/0583)
mainly on the synthesis of conjugates of antifungal agents and hydrophilic carriers based on poly(ethylene glycol)s. Ligands, i.e. the compounds with known antifungal; evaluation of their in vitro antifungal activ...
CC - Organická chemie
- 2006 - 2008 •
- 2 472 tis. Kč •
- 2 472 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2006 - 31. 12. 2008
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Application of Pd-mediated processes in drug synthesis development of novel antifungals and cytostatics based on natural lactones (GA203/04/2134)
as prototypes in the development of pharmaceutical agents. Having been inspired by the need in immunocompromised patients, we commenced research on antifungally active 3,5-disubstituted 2,5 moiety is the main structural feature of ...
CC - Organická chemie
- 2004 - 2006 •
- 1 381 tis. Kč •
- 1 381 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2004 - 1. 1. 2006
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Highly efficient sterilization of brown-rot fungi, especially S. lacrymans by selected forms of radiation, heat and new nanomaterial based fungicide (GA17-05497S)
response of the brown-rot fungi to possible new antifungal agents.The proposed project deals with some properties of brown-rot fungi (e.g. S. lacrymans, C. puteana, Gloeophyllum spp., A. vaillantii) causing a serious economical dam...
AL - Umění, architektura, kulturní dědictví
- 2017 - 2021 •
- 8 600 tis. Kč •
- 8 071 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2017 - 31. 12. 2021
Uznané náklady
Podpora ze státního rozpočtu (94%)
Poskytovatel: Grantová agentura České republiky
Development of novel compounds as tools to address unfavourable epidemiology of resistant fungal infections (NW24-05-00539)
of systemic antifungal drugs, represents a serious and escalating health problem worldwide in the hospital setting and based on this, advanced preclinical research of antifungal small-threatening infections. As part of development ...
Pharmacology and pharmacy
- 2024 - 2027 •
- 14 090 tis. Kč •
- 14 090 tis. Kč •
- MZ
Řešení projektu: 1. 5. 2024 - 31. 12. 2027
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Lactone-based natural products useful leads in the development of new antifungals and antineoplastics (GA203/07/1302)
The virtue of using natural products as prototypes of pharmaceutical agents lies in their ability to selectively bind to strategic protein targets, since binding to protein receptors is the hallmark of nearly every drug. Thus will be directe...
CC - Organická chemie
- 2007 - 2009 •
- 2 421 tis. Kč •
- 2 421 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2007 - 31. 12. 2009
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Consequences of hybridization for spread of antifungal resistance and species delimitation in pathogenic fungi model study in Aspergillus and Trichophyton (NU21-05-00681)
The spread of azole resistance in Aspergillus fumigatus and terbinafine resistance in dermatophytes is an emerging global problem. The project aims to determine the prevalence of these emerging resistances in agents of superficial (dermatoph...
Infectious Diseases
- 2021 - 2024 •
- 11 696 tis. Kč •
- 11 696 tis. Kč •
- MZ
Řešení projektu: 1. 5. 2021 - 31. 12. 2024
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
New antifungal peptides for treatment of diseases caused by yeast pathogens (TA04010638)
The project is aiming to the synthesis of novel antifungal peptides having high hygienic formulas and herewith contribute to the development of new antifungal formulas, tested in vitro and in vivo. In addition, synergistic effect of...
EE - Mikrobiologie, virologie
- 2014 - 2016 •
- 7 182 tis. Kč •
- 4 500 tis. Kč •
- TA ČR
Řešení projektu: 1. 10. 2014 - 31. 12. 2016
Uznané náklady
Podpora ze státního rozpočtu (63%)
Poskytovatel: Technologická agentura ČR
Antimycotic potential of commensal streptomycetes to combat multidrug-resistant pathogenic micromycetes (GA25-16251S)
, exacerbated by the growing incidence of resistance to commonly used antifungals source of bioactive compounds. However, the clinical potential of antifungals screening of host-associated streptomycetes has revealed the production ...
Infectious Diseases
- 2025 - 2027 •
- 12 510 tis. Kč •
- 12 510 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2025 - 31. 12. 2027
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Optimalisation of in vitro susceptibility testing of clinically important fungi to antifungal drugs (NI7464)
Standardization of the disk test for in vitro antifungal susceptibility testing. The definition of the factors affecting the disk test results. Evaluation of the utility of the disk test in laboratory testing of antifungal drugs. Ev...
FN - Epidemiologie, infekční nemoci a klinická imunologie
- 2003 - 2004 •
- 577 tis. Kč •
- 575 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2003 - 1. 1. 2004
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
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