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5 483 (0,074s) •

Project

Dendritic antigen-presenting cells in the pathogenesis of psoriasis (NK6005)

Several data of evidence implu that the psoriatic epidermis may harboue unique non-Langerhans antigen-presenting cells (preliminary data indicate CD1a+/-FceRI-DR+CD68+FXIIIa+ subtype of antigen-presenting cell). Th...

FO - Dermatovenerologie

  • 2000 - 2001
    • •
  • 688 tis. Kč
    • •
  • 688 tis. Kč
    • •
  • MZ
Project

Regulation of adaptive immune response by intestinal epithelial cells (LL2315)

Implementation of a frontier research project in the field of immunology, the subfield of host-pathogen interaction with a focus on the ability of intestinal epithelial cells to modulate the adaptive immune response through antigen prese...

Immunology

  • 2023 - 2025
    • •
  • 17 578 tis. Kč
    • •
  • 17 578 tis. Kč
    • •
  • MŠMT
Project

Inflammation Related Transitional Dendritic Cells as Key Players in T Cell Tolerance (GM25-16606M)

of a functional and safe T cell repertoire. Central to this are thymic antigen-presenting cells that present self-antigens to developing T cells to eliminate self-reactive the potential to migrate to the thymus an...

Immunology

  • 2025 - 2029
    • •
  • 25 000 tis. Kč
    • •
  • 25 000 tis. Kč
    • •
  • GA ČR
Project

Non-replicative vectors for induction of specific cellular immune responses (GA310/01/0934)

A challenge in vaccine development is the design of efficient means for induction of cellular immune responses. While exogenous antigens are mainly presented on MHC class II molecules, endogenous viral, parasite and tumor antige...

EC - Imunologie

  • 2001 - 2003
    • •
  • 4 552 tis. Kč
    • •
  • 3 632 tis. Kč
    • •
  • GA ČR
Project

Development of a new vaccine against Staphylococcus aureus (EI22_002/0000585)

. The prepared vaccine does not use either cell antigens or cell wall proteins or a live attenuated microorganism, i.e. the usually preferred antigenic bases present in other vaccines developed against staphylococci, as

Pharmacology and pharmacy

  • 2023 - 2026
    • •
  • 34 033 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • MPO
Project

The function of NK and NKT cells in thymic negative selection (GA22-30879S)

) which produce and present self-antigens to eliminate self-reactive T-cells the scope of self-antigen presentation, activated thymic dendritic cells (DCs) can highjack antigens from apoptotic mTECs and

Immunology

  • 2022 - 2024
    • •
  • 10 199 tis. Kč
    • •
  • 10 199 tis. Kč
    • •
  • GA ČR
Project

Development of technologies for early detection of tick borne encephalitis, based on changes in gene expression and protein production in infected antigen-presenting cells (LTARF18021)

In the frame of the project, differential gene expression and protein production will be analysed in antigen-presenting cells during infection by the tick-borne encephalitis virus. The differentially expressed genes and proteins wil...

Microbiology

  • 2018 - 2021
    • •
  • 7 836 tis. Kč
    • •
  • 7 836 tis. Kč
    • •
  • MŠMT
Project

Development of experimental vaccine against WT 1 for immunotherapy of tumors (NS10660)

efficient antigen processing and presentation of multiple optimized epitopes by antigen presenting cells using the mouse model. The second aim of project is development it was evaluated as a promising target a...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 10 317 tis. Kč
    • •
  • 10 317 tis. Kč
    • •
  • MZ
Project

Induction of immunity against HPV16 E6/E7 oncogenes-induced tumours with peptide- and dendritic cell-based vaccines; immunotherapy of minimal residual tumour disease. (IAA500520605)

This project is focused on the analysis of the differences in the effectiveness of the antigen presentation by dendritic cells in healthy, tumour-bearing and surgically aslocal and systemic immune dysfunctions. The problem whether a...

EC - Imunologie

  • 2006 - 2009
    • •
  • 3 329 tis. Kč
    • •
  • 3 329 tis. Kč
    • •
  • AV ČR
Project

Non-replicative vectors for induction of specific cellular immune responses (GA310/98/0432)

for induction of cellular and mucosal immune responses, because exogenous antigens are mainly presented on MHC class ll molecules. Endogenous viral, parasite and cancer antigens are, however, mostly presented on M...

EB - Genetika a molekulární biologie

  • 1998 - 2000
    • •
  • 3 642 tis. Kč
    • •
  • 3 250 tis. Kč
    • •
  • GA ČR
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