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9 806 (0,133s) •

Project

Dendritic antigen-presenting cells in the pathogenesis of psoriasis (NK6005)

Several data of evidence implu that the psoriatic epidermis may harboue unique non-Langerhans antigen-presenting cells (preliminary data indicate CD1a+/-FceRI-DR+CD68+FXIIIa+ subtype of antigen-presenting ...

FO - Dermatovenerologie

  • 2000 - 2001
    • •
  • 688 tis. Kč
    • •
  • 688 tis. Kč
    • •
  • MZ
Project

Inflammation Related Transitional Dendritic Cells as Key Players in T Cell Tolerance (GM25-16606M)

of a functional and safe T cell repertoire. Central to this are thymic antigen-presenting cells that present self-antigens to developing T cells to eliminate self-reactive the potential ...

Immunology

  • 2025 - 2029
    • •
  • 25 000 tis. Kč
    • •
  • 25 000 tis. Kč
    • •
  • GA ČR
Project

Regulation of adaptive immune response by intestinal epithelial cells (LL2315)

Implementation of a frontier research project in the field of immunology, the subfield of host-pathogen interaction with a focus on the ability of intestinal epithelial cells to modulate the adaptive immune response through antigen ...

Immunology

  • 2023 - 2025
    • •
  • 17 578 tis. Kč
    • •
  • 17 578 tis. Kč
    • •
  • MŠMT
Project

The function of NK and NKT cells in thymic negative selection (GA22-30879S)

of autoimmunity. This proces is largely mediated by medullary thymic epithelial cells (mTECs) which produce and present self-antigens to eliminate self-reactive T-cells the scope of self-antigen prese...

Immunology

  • 2022 - 2024
    • •
  • 10 199 tis. Kč
    • •
  • 10 199 tis. Kč
    • •
  • GA ČR
Project

The role of Toll-like receptor signaling in the mechanism of central tolerance (GA19-23154S)

the selfreactive repertoire within the T cell population via deletion of T cells that express a self-reactive T cell antigen receptor or their deviation into regulatory T cells (Tregs). Central to these m...

Immunology

  • 2019 - 2021
    • •
  • 8 619 tis. Kč
    • •
  • 8 178 tis. Kč
    • •
  • GA ČR
Project

Induction of immunity against HPV16 E6/E7 oncogenes-induced tumours with peptide- and dendritic cell-based vaccines; immunotherapy of minimal residual tumour disease. (IAA500520605)

of the antigen presentation by dendritic cells in healthy, tumour-bearing and surgically treated animals. Peptide-loaded dendritic cells will be used for immunotherapy aslocal and systemic immune dysfunctions. The...

EC - Imunologie

  • 2006 - 2009
    • •
  • 3 329 tis. Kč
    • •
  • 3 329 tis. Kč
    • •
  • AV ČR
Project

Development of technologies for early detection of tick borne encephalitis, based on changes in gene expression and protein production in infected antigen-presenting cells (LTARF18021)

In the frame of the project, differential gene expression and protein production will be analysed in antigen-presenting cells during infection by the tick-borne encephalitis virus. The differentially expressed genes and pro...

Microbiology

  • 2018 - 2021
    • •
  • 7 836 tis. Kč
    • •
  • 7 836 tis. Kč
    • •
  • MŠMT
Project

Development of a new vaccine against Staphylococcus aureus (EI22_002/0000585)

. The prepared vaccine does not use either cell antigens or cell wall proteins or a live attenuated microorganism, i.e. the usually preferred antigenic bases present in other vaccines developed against sta...

Pharmacology and pharmacy

  • 2023 - 2026
    • •
  • 34 033 tis. Kč
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  • 0 tis. Kč
    • •
  • MPO
Project

Development of experimental vaccine against WT 1 for immunotherapy of tumors (NS10660)

efficient antigen processing and presentation of multiple optimized epitopes by antigen presenting cells using the mouse model. The second aim of project is development it was evaluated as a promising tar...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 10 317 tis. Kč
    • •
  • 10 317 tis. Kč
    • •
  • MZ
Project

Generation of dendritic cells in vitro, their characteristics, antigen presenting capacity and potential use in the immunotherapy of minimal residual disease in (NI5669)

Monocyte-derived dendritic cells cultivated in vitro will be pulsed with tumor antigens and cocultivated with autologous lymphocytes in vitro to gain efficient cytotoxic cells directed against tumor cells. The proj...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1999 - 2001
    • •
  • 1 362 tis. Kč
    • •
  • 1 362 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 9 806