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9 (0,083s) •

Project

Modern Dosage Form for the Therapy of Oral Candidoses (NT14477)

therapy of oral candidoses is based on the application of antiseptics and antimycotics of antimycotics in the market, which has a form of mucoadhesive tablets. Unlike mucoadhesive oral antimycotics ciclopirox-olamine, and ...

FF - ORL, oftalmologie, stomatologie

  • 2013 - 2015
    • •
  • 2 983 tis. Kč
    • •
  • 2 983 tis. Kč
    • •
  • MZ
Project

Candida infections by critically ill patients in a surgical ICU (ND6884)

Wighty yeast infections in critical patients in surgical ICU are the workś object. The determination of risk factors for the infection origin is the principle of this work. The research of antimycotic preventive applicationś effects elected ...

FJ - Chirurgie včetně transplantologie

  • 2001 - 2003
    • •
  • 1 760 tis. Kč
    • •
  • 1 694 tis. Kč
    • •
  • MZ
Project

The detection of biofilm as a factor of virulence within complex diagnostics of yeast blood stream infections (NR7980)

The aim of the project is to put the theoretical knowledge about yeast biofilm into clinical praxis and to evaluate the methods of rapid diagnostics of yeasts (PCR, detection of the specific antigen). Strains of the genus Candida isolated from human ...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2004 - 2006
    • •
  • 2 721 tis. Kč
    • •
  • 2 681 tis. Kč
    • •
  • MZ
Project

Structural studies of aspartic protease from Candida parapsilosis as a tool for design of antimycotic compounds. (GA14-23022S)

Candida parapsilosis is an opportunistic pathogen threatening immunocompromised hosts. It secretes aspartic proteases that facilitate penetration of host tissues. Effect of protease inhibitors against surface candidiasis is well documented. We publis...

EE - Mikrobiologie, virologie

  • 2014 - 2015
    • •
  • 1 935 tis. Kč
    • •
  • 1 935 tis. Kč
    • •
  • GA ČR
Project

Antimycotic potential of commensal streptomycetes to combat multidrug-resistant pathogenic micromycetes (GA25-16251S)

Systemic fungal infections represent significant therapeutic challenges, exacerbated by the growing incidence of resistance to commonly used antifungals. Streptomycetes, both soil and commensal bacteria, have long been recognized as a traditional sou...

Infectious Diseases

  • 2025 - 2027
    • •
  • 12 510 tis. Kč
    • •
  • 12 510 tis. Kč
    • •
  • GA ČR
Project

Determination of the Three-Dimensional Structure of Secreted Aspartic Proteases Using Chemical Cross-Linking and High Resolution Mass Spectrometry (KJB400200501)

, candidates for antimycotic drugs....

CE - Biochemie

  • 2005 - 2007
    • •
  • 1 467 tis. Kč
    • •
  • 1 467 tis. Kč
    • •
  • AV ČR
Project

Study of structures of carbonic anhydrases from pathogenic Candida spp. as a tool for design of potential antimycotics (GA17-08343S)

Candida albicans and Candida parapsilosis are opportunistic human pathogens and represent a serious threat to immunocompromised patients. Pathogenic Candida species evolved an ability to proliferate in niches as different as human skin, gut, blood, o...

EE - Mikrobiologie, virologie

  • 2017 - 2021
    • •
  • 7 187 tis. Kč
    • •
  • 5 444 tis. Kč
    • •
  • GA ČR
Project

Enantiospecific interactions between clinically used chiral drugs and regulatory pathways of human cytochromes P450. (GA13-01809S)

of cytochromes P450; e.g. azole antimycotics and statins. It is likely that these drugs...

FR - Farmakologie a lékárnická chemie

  • 2013 - 2017
    • •
  • 9 725 tis. Kč
    • •
  • 9 725 tis. Kč
    • •
  • GA ČR
Project

Technology of the freshwater fish breeding with using of re-circulatory systems of Danish type focused on the methods of effective treatment of environment and veterinary care (QJ1210013)

The aim of the project is suggest and test in practice application of improving substances (micro granule limestone, sodium bicarbonate etc.) for optimization of hydrochemistry of water for the function of bio-filters regarding to dynamics of load of...

GL - Rybářství

  • 2012 - 2016
    • •
  • 15 518 tis. Kč
    • •
  • 13 797 tis. Kč
    • •
  • MZe
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