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23 (0,128s) •

Project

Experimental studies of potential antiproliferative effects of edible algae (LH11030)

To assess potential antiproliferative effects of edible algae and contained tetrapyrrole compounds on experimental models of cancer....

FD - Onkologie a hematologie

  • 2011 - 2014
    • •
  • 3 040 tis. Kč
    • •
  • 3 040 tis. Kč
    • •
  • MŠMT
Project

Changes in DNA profile of tumors induced by antiproliferative therapy and their clinical significance. (IZ1457)

9F - 9

  • 1993 - 1995
    • •
  • 115 tis. Kč
    • •
  • 230 tis. Kč
    • •
  • MZ
Project

Modification and in planta production of bifunctional nucleases and analysis of their anticancerogenic and biological activities (GA521/09/1214)

Previously we discovered anticancerogenic effects of plant nucleases I. Antiproliferative effects were reached at protein concentrations approximately ten-times lower in comparison to studied animal RNases and side-effects were much lower th...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 5 594 tis. Kč
    • •
  • 5 594 tis. Kč
    • •
  • GA ČR
Project

Antiproliferative, antiangiogenic and antiapoptotic effect of steroid and steroid-related agents on multiple myeloma cells (LZ1K03006)

The aim of this project is to analyse antiproliferative, antiangiogenic and proapoptotic potential of some steroids and steroid-like agents in relation to multiple myeloma cells and with a respect to their perspective usage in therapy of mye...

FD - Onkologie a hematologie

  • 2003 - 2004
    • •
  • 367 tis. Kč
    • •
  • 191 tis. Kč
    • •
  • MŠMT
Project

Antiproliferative effects of bilirubin, heme metabolites, and heme oxygenase expression on colon and pancreatic cancer. (ME 849)

detailed study on the role of bilirubin metabolism in phatogenesis of colon and pancreatic cancer, basic research, database research...

FD - Onkologie a hematologie

  • 2006 - 2009
    • •
  • 2 890 tis. Kč
    • •
  • 2 770 tis. Kč
    • •
  • MŠMT
Project

Induction of processes blocking the proliferation of leukemic cells by inhibition of transcription of ribosomal genes. (NR7998)

A linkage between the antiproliferative and proapoptotic efect of therapeutic agents and down regulation of rRNA synthesis in leukemic cells will be studied by in-vestigation of nucleolar transcription factors expression, modification and in...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 6 976 tis. Kč
    • •
  • 6 186 tis. Kč
    • •
  • MZ
Project

Local pharmacological inhibition of neointimal proliferation in venous grafts after interposing them into the abdominal aorta in rats (NR9358)

The expected outcome of our project is the introduction of a novel technique for a periadventitial polymer-based resorbable system for sustained release of antiproliferative drugs, enveloped around the auto-transplanted vein. We plan to use ...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2007 - 2010
    • •
  • 5 083 tis. Kč
    • •
  • 4 816 tis. Kč
    • •
  • MZ
Project

Benzophenanthridine alkaloids - study of their effects on cellular and molecular level (LH12176)

The aim of the project is to study benzophenanthridine alkaloids from the selected plant species in cooperation with chinese partner. The first aim is obtaining these alkaloids in sufficient amount. This assumes analysis of selected plant growing in ...

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 3 007 tis. Kč
    • •
  • 3 007 tis. Kč
    • •
  • MŠMT
Project

Influence of seminal immunosuppressor on humoral immune reaction of an organism (GA204/98/0827)

and the nosteroid inhibitor of inflammation - indomethacin - on the antiproliferative effect...

EC - Imunologie

  • 1998 - 2000
    • •
  • 1 590 tis. Kč
    • •
  • 1 590 tis. Kč
    • •
  • GA ČR
Project

Regulation of cathepsins in breast cancer therapy (IAA400550705)

and molecular modeling to derive the antagonist compound with antiproliferative activity...

CE - Biochemie

  • 2007 - 2010
    • •
  • 3 115 tis. Kč
    • •
  • 3 115 tis. Kč
    • •
  • AV ČR
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