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149 (0,113s) •

Project

Inhibition of telomerase by transition metal complexes. A new concept of antitumor drug design (NR8562)

antitumor transition metal-based drugs. The working hypothesis will be tested adducts of platinum and ruthenium complexes and antitumor activity of these compounds. Confirmation of this hypothesis will make it possible to define a ...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2008
    • •
  • 3 325 tis. Kč
    • •
  • 2 890 tis. Kč
    • •
  • MZ
Project

Mutegenic effects of platinum compounds.Relations to the development of new anticancer drugs (NL6069)

and development of antitumor platinum and ruthenium drugs.The main goal is to evaluate the risk associated with mutagenic effects of novel platinum antitumor drugs. Mutagenic effects of new antitumor drugs woll be evaluate...

FR - Farmakologie a lékárnická chemie

  • 2000 - 2002
    • •
  • 3 512 tis. Kč
    • •
  • 1 981 tis. Kč
    • •
  • MZ
Project

Mechanism of antitumor activity of metallodrugs. DNA replication and repair of DNA damage (OC09018)

replication and repair of DNA damaged by antitumor transition metal-based compounds....

BO - Biofyzika

  • 2009 - 2011
    • •
  • 1 293 tis. Kč
    • •
  • 1 293 tis. Kč
    • •
  • MŠMT
Project

Structure, recognition, and processing of DNA damage by metal-based compounds of biological significance (OC08003)

Data will be obtained describing structural and biochemical properties of DNA modified by antitumor platinum and ruthenium complexes. These findings will be exploited for improvement of structure-pharmacological relationships of metallodrugs...

BO - Biofyzika

  • 2008 - 2011
    • •
  • 1 791 tis. Kč
    • •
  • 1 791 tis. Kč
    • •
  • MŠMT
Project

Recognition of DNA modified by antitumor platinum and ruthenium complexes by zinc-finger proteins and topoisomerases (KJB400040601)

This application proposes to examine efficiency of various conventional and novel antitumor platinum and ruthenium coordination complexes to eject zinc from zinc finger proteins and whether this replacement affects binding affinity antit...

CE - Biochemie

  • 2006 - 2008
    • •
  • 1 764 tis. Kč
    • •
  • 1 764 tis. Kč
    • •
  • AV ČR
Project

Study of polymorphism and nanocompositions of lipophilic Pt(IV) complex TU31 (FW03010522)

The aim of the project is to develop two new prototypes of a new antitumor agent – a drug substance and an oral dosage form of the substance bioavailability, whereas its originally discovered antitumor efficacy will not be affected ...

Medicinal chemistry

  • 2021 - 2023
    • •
  • 9 990 tis. Kč
    • •
  • 4 004 tis. Kč
    • •
  • TA ČR
Project

Biochemistry, structural and cellular biology of ""non-classical"" antitumor platinum compounds (OC D20.001)

The major objective of this project is a fundamental research of conformational alterations induced in DNA by novel ""non-classical"" platinum compounds and processing of these changes in tumor cells. The results will improve theoretical background f...

CE - Biochemie

  • 2001 - 2005
    • •
  • 4 275 tis. Kč
    • •
  • 2 040 tis. Kč
    • •
  • MŠMT
Project

Intracellular and extracellular targets for antitumor activity and toxicity of ruthenium complexex (1P05OC070)

complexex of rhutenium as a new class of promising cytostatics effective in tumor cell resistant to platinum cytostatics...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2006
    • •
  • 705 tis. Kč
    • •
  • 522 tis. Kč
    • •
  • MŠMT
Project

Antitumor effects of bovine seminal ribonuclease on animal and human melanoblastoma, neuroblastoma, meduloblastoma and glioblastoma (GA523/01/0114)

It is projected to investigate the antitumor effects of the bovine seminal ribonuclease (BS-RNase). The main attention will be directed to the animal and human melanoblastoma ,neuroblastoma, meduloblastoma and glioblastoma tumor cells in vit...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2001 - 2003
    • •
  • 5 161 tis. Kč
    • •
  • 3 373 tis. Kč
    • •
  • GA ČR
Project

MOLECULAR MECHANISMS OF ANTITUMOR EFFECTS OF HMG-CoA REDUCTASE INHIBITORS (NR8132)

Study of mechanisms of antitumor effects of HMG-CoA reductase inhibitors on experimental model of pancreatic adenocarcinoma....

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 2 500 tis. Kč
    • •
  • 2 057 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 149