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10 347 (0,129s) •

Project

Mutegenic effects of platinum compounds.Relations to the development of new anticancer drugs (NL6069)

and development of antitumor platinum and ruthenium drugs.The main goal is to evaluate the risk associated with mutagenic effects of novel platinum antitumor drugs. Mutagenic effects of new antitumor drug...

FR - Farmakologie a lékárnická chemie

  • 2000 - 2002
    • •
  • 3 512 tis. Kč
    • •
  • 1 981 tis. Kč
    • •
  • MZ
Project

Recognition of DNA modified by antitumor platinum and ruthenium complexes by zinc-finger proteins and topoisomerases (KJB400040601)

and novel antitumor platinum and ruthenium coordination complexes to eject zinc from antitumor drugs. The results of these studies will be related to the anticancer effectiveness of theplatinum and ruthenium compounds from...

CE - Biochemie

  • 2006 - 2008
    • •
  • 1 764 tis. Kč
    • •
  • 1 764 tis. Kč
    • •
  • AV ČR
Project

Inhibition of telomerase by transition metal complexes. A new concept of antitumor drug design (NR8562)

antitumor transition metal-based drugs. The working hypothesis will be tested adducts of platinum and ruthenium complexes and antitumor activity of these compounds. Confirmation of this hypothesis will make it possible to define a ...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2008
    • •
  • 3 325 tis. Kč
    • •
  • 2 890 tis. Kč
    • •
  • MZ
Project

Antitumor effects of bovine seminal ribonuclease on animal and human melanoblastoma, neuroblastoma, meduloblastoma and glioblastoma (GA523/01/0114)

It is projected to investigate the antitumor effects of the bovine seminal ribonuclease (BS-RNase). The main attention will be directed to the animal and human melanoblastoma ,neuroblastoma, meduloblastoma and glioblastoma tumor cel...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2001 - 2003
    • •
  • 5 161 tis. Kč
    • •
  • 3 373 tis. Kč
    • •
  • GA ČR
Project

MOLECULAR MECHANISMS OF ANTITUMOR EFFECTS OF HMG-CoA REDUCTASE INHIBITORS (NR8132)

Study of mechanisms of antitumor effects of HMG-CoA reductase inhibitors on experimental model of pancreatic adenocarcinoma....

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 2 500 tis. Kč
    • •
  • 2 057 tis. Kč
    • •
  • MZ
Project

Intracellular and extracellular targets for antitumor activity and toxicity of ruthenium complexex (1P05OC070)

complexex of rhutenium as a new class of promising cytostatics effective in tumor cell resistant to platinum cytostatics...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2006
    • •
  • 705 tis. Kč
    • •
  • 522 tis. Kč
    • •
  • MŠMT
Project

Mechanism of antitumor effect of a new class of platinum compounds (IAA504406)

CE - Biochemie

  • 1994 - 1996
    • •
  • 501 tis. Kč
    • •
  • 766 tis. Kč
    • •
  • AV ČR
Project

Molecular and cellular pharmacology of novel class of antitumor iridium complexes. Implications for innovations in cancer chemotherapy (GPP303/11/P047)

that circumvent known clinical drawbacks of ?conventional? platinum antitumor drugs already targeting;(ii) to enhance our knowledge of the molecular level effects of new iridium-based agents and compare these effects with ...

FR - Farmakologie a lékárnická chemie

  • 2011 - 2013
    • •
  • 2 749 tis. Kč
    • •
  • 2 749 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanism of antitumor effect of new cytostatics based on trisubstituted platinum( II ) complexes (GA301/95/1264)

FD - Onkologie a hematologie

  • 1995 - 1997
    • •
  • 1 164 tis. Kč
    • •
  • 1 164 tis. Kč
    • •
  • GA ČR
Project

Biophysical analysis of DNA condensation. Effect of new organometallic compounds of biological significance. (GA13-08273S)

. To enhance our knowledge of the molecular and macromolecular level effects of antitumor and antibacterial agents, the effects of several new organometallic compounds on DNA of these studies will be correlated with ant...

BO - Biofyzika

  • 2013 - 2016
    • •
  • 5 414 tis. Kč
    • •
  • 5 414 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 10 347