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13 (0,064s) •

Project

Lymphokine induced differentiation of human leukemic cells. (IZ1917)

9F - 9

  • 1994 - 1996
    • •
  • 1 499 tis. Kč
    • •
  • 1 999 tis. Kč
    • •
  • MZ
Project

Correlation of proliferative and apoptopic dynamics in hematopathology, related to clinical and morphological parameters in bone marrow biopsies. (NC4637)

The project aims at assessment of proliferative activity and spoptosis of cells of the bone marrow in certain types of diseases,in relation to their treatment. Morphological methods and methods of meleculary bilogy for the study of expression of prol...

FD - Onkologie a hematologie

  • 1998 - 2001
    • •
  • 2 878 tis. Kč
    • •
  • 2 878 tis. Kč
    • •
  • MZ
Project

MECHANISMUS OF Bcl-2 ACTION (NC5463)

Bcl-2 protooncogene prevents apoptosis of HeLa G cells,but induces apoptosis of BSC-40 cells.We will study its interactions with other cellular proteins and the effect on the energy metabolism,especially on mitochondrial function and glycalysis. Usin...

EB - Genetika a molekulární biologie

  • 1999 - 2001
    • •
  • 2 184 tis. Kč
    • •
  • 2 184 tis. Kč
    • •
  • MZ
Project

Center for Experimental Hematology (LC06044)

Experimental hematology studies the pathophysiology of blood diseases including tumours. Aim of the project is to identify novel cellular and molecular mechanisms involved in the regulation of normal and pathological haematopoiesis. The integration o...

FD - Onkologie a hematologie

  • 2006 - 2011
    • •
  • 38 824 tis. Kč
    • •
  • 38 824 tis. Kč
    • •
  • MŠMT
Project

Interactions of Wnt and Ah receptor signaling in regulation of functions of liver cells (GA524/09/1337)

Toxic compounds activating Ah receptor (AhR) present an important group of environmental polutants, which may have deleterious effects on both animal and human health. Analysis of signaling pathways affected by AhR enables to describe both the mechan...

ED - Fyziologie

  • 2009 - 2011
    • •
  • 3 614 tis. Kč
    • •
  • 3 614 tis. Kč
    • •
  • GA ČR
Project

Chatacteristic of resistance of adult stem cells to genotoxic stress (GA304/09/1568)

Stem cells (SC) are a promising tool, which could allow tissue regeneration. Regardless of their localization in various tissues in human organism SC have unique abilities of proliferation, differentiation an plasticity. The aim of proposed project i...

EA - Morfologické obory a cytologie

  • 2009 - 2011
    • •
  • 3 564 tis. Kč
    • •
  • 3 564 tis. Kč
    • •
  • GA ČR
Project

Novel anticancer platinum complexes - mechanisms of their action and innovative chemotherapy strategies (GA301/07/1557)

The role of (phospho-)lipid metabolism, and notably of polyunsaturated fatty acids, in effects a) of cisplatin and b) of novel highly efficient platinum cytostatics LA-9 and LA-12, originally synthesized in the Czech Republic, will be investigated in...

FD - Onkologie a hematologie

  • 2007 - 2011
    • •
  • 7 577 tis. Kč
    • •
  • 7 577 tis. Kč
    • •
  • GA ČR
Project

Importance of cell lipid changes during differentiation and apoptosis of colon epithelial cells (GA524/07/1178)

In the colon, dietary compounds and endogenous factors regulating cell growth, differentiation and apoptosis operate together, which may have substantial impact determining metabolism and kinetic of colon epithelial cells. Following our previous resu...

ED - Fyziologie

  • 2007 - 2011
    • •
  • 8 163 tis. Kč
    • •
  • 8 163 tis. Kč
    • •
  • GA ČR
Project

The role of extracellular matrix-mediated cell adhesion in maintenance of colonic tissue homeostasis and in colon carcinogenesis (GA305/09/1526)

Right physiological functioning of the intestinal tissue is important for general health of mammalian organism. In colon crypt the epithelial cells migrate upward and on the top die by anoikis associated with cell-extracellular matrix (ECM) interacti...

ED - Fyziologie

  • 2009 - 2011
    • •
  • 2 718 tis. Kč
    • •
  • 2 718 tis. Kč
    • •
  • GA ČR
Project

Targeted inhibition of BCL2 family proteins in experimental therapy of diffuse large B-cell lymphoma (DLBCL) (NV15-27757A)

Diffuse large B-cell lymphoma (DLBCL) represents the most prevalent type of non-Hodgkin lymphomas (NHL) in the Western hemisphere. BCL2 and MCL1 belong to key regulators of intrinsic (mitochondrial) apoptosis. BCL2 was repeatedly associated with poor...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 6 991 tis. Kč
    • •
  • 6 991 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 13