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345 (0,206s) •

Project

Introduction and use of new array-CGH technology for precise determination of copy changes in patients suffering from acute myeloid and lymphoblastic leukemia (NE7644)

The introduction of new microarray technology ( array-CGH) for determination leukemia. Use of array-CGH technique in patients suffering from acute myeloid identification od deletions and amplifications of 300 targe...

EB - Genetika a molekulární biologie

  • 2003 - 2005
    • •
  • 3 671 tis. Kč
    • •
  • 3 656 tis. Kč
    • •
  • MZ
Project

High throughput detection of genetic alterations in chronic lymphocytic leukemia using array comparative genomic hybridization (NR9484)

I. The utilization of array comparative genomic hybridization (array-CGH) for determination of DNA copy number changes in patients with chronic B lymphocytic leukemia (B-CLL). II. The utilization of specific microarray (esp...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 8 360 tis. Kč
    • •
  • 7 861 tis. Kč
    • •
  • MZ
Project

New approaches to early diagnostics of autism (LD11028)

Development of new methods which could be broadly used for early diagnostics of autism both in the Czech Republic and abroad. Special emphasis on "at risk" younger siblings of autistic children who have already been diagnosed.......

FL - Psychiatrie, sexuologie

  • 2011 - 2014
    • •
  • 3 212 tis. Kč
    • •
  • 2 419 tis. Kč
    • •
  • MŠMT
Project

Instability of the genome of bone marrow cells of patients with AML and MDS. (OC10043)

, CGH) and as the new approach we will start to use array CGH analyses. We will start pilot study with the specially designed chip for array CGH analyses......

EB - Genetika a molekulární biologie

  • 2010 - 2012
    • •
  • 2 100 tis. Kč
    • •
  • 2 100 tis. Kč
    • •
  • MŠMT
Project

Mechanism of sensitivity and resistance to L-Asparaginase in leukemic cells (NT12429)

synthetase. High throughput methods, such as MicroArray, protein bead and CGH array...

FG - Pediatrie

  • 2011 - 2015
    • •
  • 8 593 tis. Kč
    • •
  • 8 593 tis. Kč
    • •
  • MZ
Project

Diagnostic utility of hTERC and MYCC genes amplifications in initiations and development of cervical intraepithelial dysplasia and cervical carcinoma (NT11089)

. Samples of cervical carcinoma will be examined by the array-CGH technique . The aim...

EB - Genetika a molekulární biologie

  • 2010 - 2013
    • •
  • 4 975 tis. Kč
    • •
  • 4 975 tis. Kč
    • •
  • MZ
Project

Mechanisms of imatinib resistance in patients with chronic myelogenous leukaemia (NR7870)

In patients with Ph+ CML the residual, in vitro-IM-resistant subclones are tested for qualitative changes (using sequencing of BCR/ABL ATP-binding pocket) and for quantitative gene changes using DNA (CGH microarray) technology.......

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 3 370 tis. Kč
    • •
  • 3 187 tis. Kč
    • •
  • MZ
Project

Turnover of sex chromosomes in the karyotype evolution of Lepidoptera (GA14-22765S)

. For this purpose, we will identify Z-linked genes in a basal species Hepialus humuli via array-CGH and qPCR. Furthermore, we will perform molecular cytogenetic analysis of sex......

EB - Genetika a molekulární biologie

  • 2014 - 2016
    • •
  • 6 825 tis. Kč
    • •
  • 6 825 tis. Kč
    • •
  • GA ČR
Project

The role of in vitro sensitivity to tyrosine kinase inhibitors estimation in management of patients with chronic myeloid leukemia (NS9949)

Assessment of in vitro sensitivity of leukemic cells from patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors and its implications for the therapy management. Clones of in vitro imatinib-resistant cells, obtained from patie...

FD - Onkologie a hematologie

  • 2008 - 2010
    • •
  • 3 717 tis. Kč
    • •
  • 3 713 tis. Kč
    • •
  • MZ
Project

Identification of genetic defects in families of patients with autism (NT14200)

(using MLPA, FISH, array CGH etc.). In about 15-20 unrelated patients exomes and microduplications (CNVs) using SNP arrays. The findings will be assessed bioinformatically......

EB - Genetika a molekulární biologie

  • 2013 - 2015
    • •
  • 7 088 tis. Kč
    • •
  • 7 088 tis. Kč
    • •
  • MZ
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