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33 (0,119s) •

Project

Role of astrocyte gap junctions in neurotransmission. (MEB021140)

that the connectivity and Ca2+ signaling of astrocytic networks contribute to neuronal transmission and plasticity we set two specific aims: 1. To investigate the role of astrocytic network the astrocytic mechanisms involv...

FH - Neurologie, neurochirurgie, neurovědy

  • 2011 - 2012
    • •
  • 128 tis. Kč
    • •
  • 128 tis. Kč
    • •
  • MŠMT
Project

The astrocyte nanofilament system in Alexander disease – from molecules to function, uncovering new leads for therapy (8F20006)

, an astrocyte intermediate filament (nanofilament) protein. The disease starts in astrocytes. However, it is not known how AxD astrocytes cause the disease, and the available pluripotent stem cells from AxD patients to der...

Other medical science

  • 2020 - 2024
    • •
  • 6 356 tis. Kč
    • •
  • 3 252 tis. Kč
    • •
  • MŠMT
Project

Astrocyte-microglia communication as a target for stroke therapy (GA23-05327S)

- and space- dependent manner. Astrocytes and microglia represent key components in the stroke pathobiology. To characterize astrocyte-microglia interaction network during by astrocytes and microglia in ischemic mouse brain...

Neurosciences (including psychophysiology)

  • 2023 - 2025
    • •
  • 10 874 tis. Kč
    • •
  • 10 874 tis. Kč
    • •
  • GA ČR
Project

Age-related changes in the structure and function of astrocytes (GA305/08/1384)

fluorescent astrocytes that enables the unequivocal identification of these cells and cerebellum). We will examine physiological and structural variables of astrocyte function in depth, in situ profile of ageing astrocytes...

FH - Neurologie, neurochirurgie, neurovědy

  • 2008 - 2009
    • •
  • 2 530 tis. Kč
    • •
  • 2 530 tis. Kč
    • •
  • GA ČR
Project

Gene expression profiling and functional characterization of glial cell subpopulations following ischemic brain injury (GA13-02154S)

Astrocytes and NG2-glia subpopulations display striking physiological/functional heterogeneity, which is reflected by marked differences in their gene high throughput platform will be employed to classify astrocytic and NG2-glia and...

EB - Genetika a molekulární biologie

  • 2013 - 2016
    • •
  • 10 720 tis. Kč
    • •
  • 10 720 tis. Kč
    • •
  • GA ČR
Project

Cell volume regulation in glial cells during brain ischemia/reperfusion (GAP303/10/1338)

The aim of this study is to identify the major ion channels or transporters participating in astrocyte and NG2 glia swelling and volume regulation during ischemia astrocyte swelling results in brain edema after ischemic injury, a fu...

FH - Neurologie, neurochirurgie, neurovědy

  • 2010 - 2012
    • •
  • 3 996 tis. Kč
    • •
  • 3 996 tis. Kč
    • •
  • GA ČR
Project

Identification of changes in glutamatergic pathways specific for sporadic form of Alzheimer's disease in human neurons and astrocytes induced from patient's cells (NU20-09-00437)

and astrocytes) in patients with AD. Using the induced pluripotent cell method (iPSC in human astrocytes induced from cells of patients with sporadic AD. Our results will help reveal the mechanisms responsible for astrocytic

Neurosciences (including psychophysiology)

  • 2020 - 2023
    • •
  • 12 650 tis. Kč
    • •
  • 12 526 tis. Kč
    • •
  • MZ
Project

Membráne properties of astrocytes and the role of extracellular matrix molecules during astrogliosis in the CNS (GA305/02/1528)

in the brain of normal and three types of transgenic animals:mice with astrocytes visualized by the presence of green fluorescence protein, mice lacking astrocytic......

FH - Neurologie, neurochirurgie, neurovědy

  • 2002 - 2004
    • •
  • 3 472 tis. Kč
    • •
  • 2 932 tis. Kč
    • •
  • GA ČR
Project

The diagnostic and therapeutic potential of fibroblast activation protein (FAP) in human astrocytic tumors (NT12237)

Malignant gliomas represent tumors with dismal prognosis. Previous work of the applicant demonstrated a grade dependent increase of dipeptidyl peptidase (DPP)-IV enzymatic activity in human astrocytic tumors. This enzymatic activity is a com...

FD - Onkologie a hematologie

  • 2011 - 2015
    • •
  • 7 268 tis. Kč
    • •
  • 7 268 tis. Kč
    • •
  • MZ
Project

Investigation of membrane and morphological properties of astrocytes, oligodendrocytes and neurons in CNS during pathology using fluorescent proteins (GA305/06/1464)

, astrocytes and neurons after brain injury in transgenic mice in which different types...

FH - Neurologie, neurochirurgie, neurovědy

  • 2006 - 2008
    • •
  • 2 568 tis. Kč
    • •
  • 2 568 tis. Kč
    • •
  • GA ČR
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