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3 (0,161s)

Project

Analysis of expression of STAT, JAK and SOCS in glial tumors of brain and in carcinomas of breast and prostate gland. Correlation with grading, expression of steroid receptors and expression of proteins regulating cell cycle and apoptosis. (1A8244)

Disruption of signaling of JAK/STAT/SOCS may be the cause of failure of immune surveillance and may participate in development and invasion of various tumors, including carcinomas of prostate gland, breast and glial tumors of brain. The aim is analys...

EB - Genetika a molekulární biologie

  • 2004 - 2006
  • 1 665 tis. Kč
  • 1 419 tis. Kč
  • MZ
Project

The study of antitumor activity of synthetic ligands of PPARs on glioblastoma cell lines and on explants of glial tumors of brain (NR8370)

To find if selected synthetic ligands of PPARs (ciglitazone, etc.) affect growth and differentiation of cell explants of glial tumors. Analysis of effect of PPAR antagonists (Diclofenac, Nimesulid, MK 886, etc.) on proliferation and differentiation o...

EB - Genetika a molekulární biologie

  • 2005 - 2007
  • 2 915 tis. Kč
  • 2 215 tis. Kč
  • MZ
Project

Modulation of expression and activity of some genes regulating cell cycle and apoptosis by steroids and their receptors in the glial tumours (NC6726)

To elucidate if the steroid hormones and their receptors participate in the modulation of expression of genes regul. apopt.,proliferation and different. of glial cells and if they contribute to the development and growth of malignant tumours of the b...

FD - Onkologie a hematologie

  • 2001 - 2003
  • 2 171 tis. Kč
  • 2 118 tis. Kč
  • MZ
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