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7 (0,078s) •

Project

Diagnostic markers and pathophysiological mechanisms of atypical parkinsonian syndromes (NT12288)

The project is designed to study clinical and paraclinical markers with a high positive predictive diagnostic value for atypical parkinsonian syndromes and to investigate the contribution of the inhibitory GABA-ergic system in the disorders of gait, ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2011 - 2015
    • •
  • 8 122 tis. Kč
    • •
  • 8 122 tis. Kč
    • •
  • MZ
Project

New approaches for the prevention of cardiac atrophy studies in rat model heterotopically transplanted heart (NV16-27420A)

Cardiac atrophy is the main detrimental change in fully unloaded heart during the long-term left ventricle assist device (LVAD) support. In view of recent findings that activation of pathways of fatty acid (FA) transport with subsequent increases in ...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2016 - 2019
    • •
  • 9 627 tis. Kč
    • •
  • 9 627 tis. Kč
    • •
  • MZ
Project

The new insight on the pathophysiology of cardiac atrophy after implantation of left ventricular assist device translation studies to define new therapeutic targets (NU22-02-00070)

Cardiac atrophy is a critically important detrimental change in the heart that is unloaded because of long-term left ventricle assist device support. In view of knowledge that there are important sex-related differences in the cardiovascular diseases...

Cardiac and Cardiovascular systems

  • 2022 - 2025
    • •
  • 11 218 tis. Kč
    • •
  • 11 218 tis. Kč
    • •
  • MZ
Project

Sleep and brain changes related to memory decline in mild cognitive impairment (NV18-07-00272)

The expected aging of the population will increase people with memory disease and dementia, especially Alzheimer's disease. Mild cognitive impairment (MCI) is a risk syndrome in which intervention can delay the development of Alzheimer's disease. Sle...

Clinical neurology

  • 2018 - 2022
    • •
  • 9 433 tis. Kč
    • •
  • 9 433 tis. Kč
    • •
  • MZ
Project

The effect of gluten-free diet on clinical symptoms, immune parameters and metabolome in neurodegenerative diseases with alfa-synucleinopathy (NU21-04-00443)

Recent data suggest that the brain-gut axis, chronic intestinal inflammation and microbiome may contribute to the pathogenesis of neurodegenerative diseases with alfa-synucleinopathy, which include Parkinson`s disease (PD) and Multiple system atrophy...

Neurosciences (including psychophysiology)

  • 2021 - 2025
    • •
  • 13 335 tis. Kč
    • •
  • 13 335 tis. Kč
    • •
  • MZ
Project

Myokines and metabolically active molecules in the pathogenesis of idiopathic inflammatory myopathies (NU21-05-00322)

Patients with idiopathic inflammatory myopathies (IIM) suffer from muscle weakness and muscle wasting, a condition in which increased pro-atrophic and decreased anabolic factors, such as myokines myostatin and follistatin, would be expected. However,...

Rheumatology

  • 2021 - 2025
    • •
  • 10 887 tis. Kč
    • •
  • 10 887 tis. Kč
    • •
  • MZ
Project

Video analysis of hypomimia in Parkinson's disease and other synucleinopathies (NU23J-04-00042)

Currently, no sufficiently accurate diagnostic or progressive biomarker of alfa-synucleinopathy (aSYN) is available that would allow early intervention to prevent the disease progression with potential neuroprotective therapies. Disruption or complet...

Neurosciences (including psychophysiology)

  • 2023 - 2026
    • •
  • 6 843 tis. Kč
    • •
  • 6 843 tis. Kč
    • •
  • MZ
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