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3 (0,124s)

Project

Disease-causing alterations of immune repertoire and leukocyte signaling in patients with inborn errors of immunity and autoinflammation (NV19-05-00332)

Primary Immunodeficiency Diseases (PIDD) are a group of disorders of the immune system, with over 300 causal mutations described to date. Immune dysregulation manifesting as autoimmunity and autoinflammation was described as a negative progn...

Immunology

  • 2019 - 2022
  • 5 399 tis. Kč
  • 5 399 tis. Kč
  • MZ
Project

Adaptor protein PSTPIP2 and chronic multifocal osteomyelitis in mouse models and human patients (GA23-06676S)

Chronic recurrent multifocal osteomyelitis (CRMO) is a chronic disease characterized by autoinflammatory lesions in the bones. The molecular basis of the disease is unknown. The most important animal model of this disease is the mouse strain Pstpip2c...

Biochemistry and molecular biology

  • 2023 - 2025
  • 9 235 tis. Kč
  • 9 043 tis. Kč
  • GA ČR
Project

Programmed cell death regulation as a mechanism of immune tolerance (GA24-12173S)

will study how aberrant cell death contributes to autoinflammation in the condition...

Cell biology

  • 2024 - 2026
  • 11 757 tis. Kč
  • 11 757 tis. Kč
  • GA ČR
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