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1 553 (0,18s) •

Project

Role of BCR-ABL in CML cases with poor response to therapy but with low BCR-ABL transcript levels (NC7550)

In some of CML patients with poor response to treatment we have found low BCR-ABL transcript levels. We will study the role of BCR-ABL as well as BCR and ABL in order to find out whether CML mecha...

FD - Onkologie a hematologie

  • 2003 - 2005
    • •
  • 6 625 tis. Kč
    • •
  • 6 510 tis. Kč
    • •
  • MZ
Project

Chronic myeloid leukemia radiation risk estimation based on BCR-ABL distances in hemotopoietic cells (GA202/02/0804)

to becaused by a translocation between ABL and BCR;almost all CML patients have the BCR studies. Using 3D confocal microscopy we shall measure BCR-to-ABL distances in human hematopoietic stem cells suppos...

BG - Jaderná, atomová a molekulová fyzika, urychlovače

  • 2002 - 2004
    • •
  • 3 714 tis. Kč
    • •
  • 1 746 tis. Kč
    • •
  • GA ČR
Project

Identification of novel therapeutic targets in chronic myeloid leukemia via systematic analysis of BCR-ABL interactome (NV15-34405A)

from chromosomal translocation producing a chimeric BCR-ABL protein with unregulated tyrosine kinase (TK) activity. Targeting of the BCR-ABL activity by the TK that the CML patients often acquire BCR-...

EB - Genetika a molekulární biologie

  • 2015 - 2018
    • •
  • 11 982 tis. Kč
    • •
  • 11 982 tis. Kč
    • •
  • MZ
Project

P-glycoprotein and its possible contribution to development of resistance to Imatinib in Bcr-Abl expressing cells (NR9482)

Study of the P-gp contribution to the development of resistance to imatinib in Bcr-Abl positive cells using the direct determination of intracellular content of the drug.......

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 3 184 tis. Kč
    • •
  • 3 116 tis. Kč
    • •
  • MZ
Project

Molecular markers of chronic myeloid leukemia progression to blast crisis. (NC5902)

We shall search for early markers of CML progression into acute phase to be able to interrupt this progression with timely treatment. As possible markers,we shall identify the genes differentially expressed in different stages of CML by the ...

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 6 639 tis. Kč
    • •
  • 6 390 tis. Kč
    • •
  • MZ
Project

Chronic myeloid leukemia immunological studies with mouse and human cells transformed by the bcr-abl fusion gene (NS10634)

The proposed study aims at broadening the present knowledge of the immune reactivity against bcr-abl- transformed cells in mice. New vaccines based on gene-modified cells will be constructed and tested in animals which had been inoc...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 12 012 tis. Kč
    • •
  • 12 012 tis. Kč
    • •
  • MZ
Project

Sensitivity and resistance of Bcr/Abl leukemia cells to STI571 in vitro (GA301/04/1239)

STI571 inhibits the Bcr/Abl tyrosine kinase, and is therefore the treatment-resistant subclones derived from patients, for qualitative (using sequencing of BCR/ABL technology. We hypothesize that pre-existing genom...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 4 662 tis. Kč
    • •
  • 4 462 tis. Kč
    • •
  • GA ČR
Project

Detection of de novo methylation at the bcr-abl locus in the course of chronic myelogenous leukemia. (IZ3720)

FD - Onkologie a hematologie

  • 1996 - 1998
    • •
  • 684 tis. Kč
    • •
  • 684 tis. Kč
    • •
  • MZ
Project

Biology of BCR/ABL1-positive leukaemias (NV16-30186A)

BCR-ABL1 fusion is a hallmark of chronic myeloid leukaemia (CML) and is present also in a subset of acute lymphoblastic leukaemia (ALL). Our previous studies in lymphoid blast crisis. In the proposed project we aim to disclose background of ...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 9 667 tis. Kč
    • •
  • 9 667 tis. Kč
    • •
  • MZ
Project

Changes in the structure of interphase nucleai of human leukemic cell lines after treatment with differentiating agents and gama irradiation (GA202/98/P253)

the treatment with differentiating agents and after gamma-irradiation. Changes of abl, bcr,q11) which leads to chimeric bcr-abl gene (Philadelphia chromosome)that plays, the reverse transcription polymerase chain ...

EB - Genetika a molekulární biologie

  • 1998 - 2001
    • •
  • 768 tis. Kč
    • •
  • 708 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 1 553