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449 (0,073s) •

Project

Familial hypertrophic cardiomyopathy detection of mutations in exon 13 of the beta-myosin heavy chain. (IZ2971)

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 1995 - 1997
    • •
  • 771 tis. Kč
    • •
  • 723 tis. Kč
    • •
  • MZ
Project

Function of nuclear myosin in gene expression (GA204/04/0108)

We have demonstrated previously the presence of myosin I beta in nucleus. We that the nuclear myosin and actin are required for transcription by RNA polymerases I and II, described that the myosin has a capacity to...

EA - Morfologické obory a cytologie

  • 2004 - 2006
    • •
  • 3 313 tis. Kč
    • •
  • 3 313 tis. Kč
    • •
  • GA ČR
Project

Familiar hypertrophic cardiomyopathy detection of mutations in exons 14, 16, 20, 23 of the gene coding for beta-myosin heavy (MYH7). (NA4966)

Detetion of mutations in exons 14,16,20.23 of gene coding for heavy chain of B-myosin(MYH7)by means of DGGE,SSCP on capillary electrophoresis and direct sequencing. Mutations on DNA of MYH7 are frequent cause of familiar hypertrophic cardiom...

EB - Genetika a molekulární biologie

  • 1998 - 2000
    • •
  • 9 723 tis. Kč
    • •
  • 4 556 tis. Kč
    • •
  • MZ
Project

Charakterization of putative probably nuclear myosin I (ME 470)

The project aims to define functions of the newly discovered nuclear myosin in the cell nucleus. Methods of molecular biology and microscopy will be used including observing GFP-constracts in living cells.......

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 3 687 tis. Kč
    • •
  • 1 527 tis. Kč
    • •
  • MŠMT
Project

Function of nuclear myosin I (GA304/01/0661)

We have demonstrated previously the presence of a 120 kDa, myosin 1-like protein in the nucleus. Microsequencing and analysis of the cDNA have then revealed that the 120 kDa protein is a form of myosin Iß that contains a unique 16 a...

EA - Morfologické obory a cytologie

  • 2001 - 2003
    • •
  • 5 233 tis. Kč
    • •
  • 3 266 tis. Kč
    • •
  • GA ČR
Project

Cooperative contribution of actin- and myosin-families to the chromatin dynamics and tranion in the cell nucleus (LH12143)

Identification of principles of collaborative action of actin-related Arp6) and myosin (NM1) proteins in functional organization of the cell nucleus and chromatin. The project aims to asses especially their contribution to the organization o...

EB - Genetika a molekulární biologie

  • 2012 - 2014
    • •
  • 3 635 tis. Kč
    • •
  • 3 635 tis. Kč
    • •
  • MŠMT
Project

Force coupling between microtubules and actin filaments mediated by unconventional myosins. (GA15-17488S)

, actin filaments and microtubules, such as unconventional myosin-I and -X, were shown to be necessary for proper spindle remodeling. However, how are the actin-myosin generated myosins and in vitro reconstituted microtubul...

BO - Biofyzika

  • 2015 - 2017
    • •
  • 4 737 tis. Kč
    • •
  • 4 737 tis. Kč
    • •
  • GA ČR
Project

Characterization of a putative nuclear myosin I (ME 143)

A novel nuclear 120kDa protein has been characterized as myosin I isoform. It binds l25I-calmodulin and is photoaffinity-labeled with ATP. Column fractions containing the 120 kDa protein contain K+-EDTA ATPase activity. The partially purifie...

EA - Morfologické obory a cytologie

  • 1998 - 2000
    • •
  • 1 345 tis. Kč
    • •
  • 1 051 tis. Kč
    • •
  • MŠMT
Project

Inherited thrombocytopenias caused by mutations in the gene (MYH9) encoding nonmuscle myosin (NR8762)

In our study we will focus on DNA and protein analysis and correlation between mutations and clinical manifestations in patients with MYH9-related disorders.......

EB - Genetika a molekulární biologie

  • 2006 - 2008
    • •
  • 6 581 tis. Kč
    • •
  • 6 012 tis. Kč
    • •
  • MZ
Project

The role of distal nerve stump on remodelling of capillary network and myosin heavy chain isoform transformation in denervated rat skeletal muscle. (MEB090910)

To measure the influence of distal nerve stump on expression of denervation changes in fast (extensor digitorum - EDL) and slow (soleus - SOL) rat skeletal muscle (changes in capillary bed and myosin heavy chain transformation).......

FH - Neurologie, neurochirurgie, neurovědy

  • 2009 - 2010
    • •
  • 122 tis. Kč
    • •
  • 122 tis. Kč
    • •
  • MŠMT
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