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116 (0,09s) •

Project

Bifunctional chelates. Synthesis and complexing properties (GA203/02/0493)

Synthesis of new bifunctional chelators derived from azacycles with acetic and methylphosphonic/phosphinic acid pendants, study of their coordination ability toward freechelator and the chelator bonded to the simple biomole...

CA - Anorganická chemie

  • 2002 - 2004
    • •
  • 3 000 tis. Kč
    • •
  • 1 785 tis. Kč
    • •
  • GA ČR
Project

Radionuclide precursors for synthesis of new radiopharmaceuticals for therapeutic applications (1QS100480501)

with bifunctional chelate, which subsequently intermediates its binding to biomolecule (most or phosphinic derivatives of macrocyclic DOTA chelates. Preparation and therapeutic potency......

CH - Jaderná a kvantová chemie, fotochemie

  • 2005 - 2009
    • •
  • 8 972 tis. Kč
    • •
  • 8 972 tis. Kč
    • •
  • AV ČR
Project

The electron deficient transition metal complexes containing bifunctional beta-diketiminate and cyclopentadienyl ligands ? design of new catalysts. (GAP106/10/0924)

The aim of project will be the preparation of coordination compounds of electron deficient III.B - VI.B group transition metals containing a stabilizing N-chelate forming ligands and a cyclopentadienyl ring. As the base of N-chelate...

CA - Anorganická chemie

  • 2010 - 2014
    • •
  • 6 738 tis. Kč
    • •
  • 6 738 tis. Kč
    • •
  • GA ČR
Project

Artificial siderophores for molecular imaging applications (GF24-14579L)

the most successfully used, available as the iron chelator, but also as bifunctional chelator for radiometals for developing molecular imaging probes in particularNature has designed specific chelators for a varie...

Oncology

  • 2024 - 2026
    • •
  • 6 975 tis. Kč
    • •
  • 6 975 tis. Kč
    • •
  • GA ČR
Project

*Liquid fertilizer with complex and chelate bonded trace nutrients. (FT-TA3/076)

*The aim of the project is to find suitable complex and chelate compounds that facilitate uptake of micronutrients by plants. Only the compounds available on the market will be tested. Uptake of different forms of micronutrients (ionic salts...

CA - Anorganická chemie

  • 2006 - 2009
    • •
  • 13 800 tis. Kč
    • •
  • 8 798 tis. Kč
    • •
  • MPO
Project

Study of protective effects of novel iron chelators in the heart injury induced by oxidative stress and anthracycline cytostatics (GP305/05/P156)

prevention of these damages using novel iron chelators of the aroylhydrazone group-chelating efficacy. An in vitro model for the study of chelators at the level of cardiac chelators, an in vivo research will follo...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2007
    • •
  • 1 184 tis. Kč
    • •
  • 1 184 tis. Kč
    • •
  • GA ČR
Project

Anti-tumor effects of chelation therapy in myelodysplastic syndrome and identification of new therapeutic biomarkers. (NV16-31689A)

patients are typically transfusion dependent, and their chelation therapy not only to iron chelator in vitro. In vivo, 6-week applications of chelator to preleukemia+ cells from low-risk MDS patients receiving chelatio...

FD - Onkologie a hematologie

  • 2016 - 2020
    • •
  • 9 877 tis. Kč
    • •
  • 9 665 tis. Kč
    • •
  • MZ
Project

Effect of polyphenols and chelators on toxicity and effects of anthracyclines and taxanes (NL7567)

we will study effects of polyphenols and chelators on physical, chemical and biochemical interactions of doxorubin and its metabolites with Fe ions and enzymes in ROS effects of polyphenols and chelators on cardiotoxicity of doxorub...

FR - Farmakologie a lékárnická chemie

  • 2003 - 2005
    • •
  • 5 395 tis. Kč
    • •
  • 2 443 tis. Kč
    • •
  • MZ
Project

Efficient killing of cancer cells via mitochondrial targeting of iron chelators (GA18-13103S)

and iron chelation leads to apoptosis induction especially in cancers of hematopoietic origin, yet, the remaining problem is the specificity and toxicity of the chelators chelation. Our preliminary data show a strong enhan...

Biochemistry and molecular biology

  • 2018 - 2022
    • •
  • 7 144 tis. Kč
    • •
  • 7 144 tis. Kč
    • •
  • GA ČR
Project

Luminiscent lanthanide complexes in analytical and diagnostic applications. (OC D18.001)

The project is focused on development of lanthanide(III) chelates for diagnostics and therapy and the goals are summerised in the topics:i)Relationship between structure and activity of Ln(III) chelates relevant to Magnetic resonanc...

CA - Anorganická chemie

  • 2001 - 2004
    • •
  • 3 210 tis. Kč
    • •
  • 2 240 tis. Kč
    • •
  • MŠMT
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