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1 571 (0,186s) •

Project

Analysis of bile acids as a new, non-invasive method for diagnosing gastroesophageal reflux disease and screening of Barrett’s esophagus. (NU23-08-00303)

Barrett’s esophagus and esophageal adenocarcinoma. Bile acids have been shown of bile acids is however complex and their conjugation status and pH are the major diagnostic methods are not able to analyze individua...

Gastroenterology and hepatology

  • 2023 - 2026
    • •
  • 12 604 tis. Kč
    • •
  • 12 604 tis. Kč
    • •
  • MZ
Project

Supramolecular systems in chemical biology (OC10001)

The objective of the project is a synthesis of convenient synthons of supramolecular systems based on phytosterol units, or in combination with bile acid units, designing of their conjugates with small molecules, and investigation o...

CC - Organická chemie

  • 2010 - 2012
    • •
  • 1 500 tis. Kč
    • •
  • 1 500 tis. Kč
    • •
  • MŠMT
Project

Cholesterol 7alpha-hydroxylase polymorphism as a predictor cholesterolemia responsiveness (NT13151)

-week therapy with bile acid sequestrant by more pronounced decrease sensitivity induced by changes in bile acid metabolism after sequestrant administration will be studied in healthy volunteers. It will be also an...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2012 - 2015
    • •
  • 5 177 tis. Kč
    • •
  • 5 177 tis. Kč
    • •
  • MZ
Project

Novel interventions for the treatment of triglycerides, cholesterol and bile acids diseases with human CAR ligands (GA19-14497S)

regulates important genes controlling glucose, lipid, cholesterol and bile acids data, if CAR stimulates or repress triglyceride and bile acid synthesis under and bile acids metabolism and homeos...

Pharmacology and pharmacy

  • 2019 - 2021
    • •
  • 12 826 tis. Kč
    • •
  • 12 662 tis. Kč
    • •
  • GA ČR
Project

Bile acid malabsorption in oncology patients. Concept 3P Medicine (prevention of bile acid malabsorption associated complications, prediction, and personalization) (NW25-09-00063)

Bile acid malabsorption (BAM) is a common condition observed, as a complication and is associated with minimal radiation dose. The mainstay of treatment for BAM is bile acid sequestrants. They bind the bile

Oncology

  • 2025 - 2028
    • •
  • 11 941 tis. Kč
    • •
  • 11 171 tis. Kč
    • •
  • MZ
Project

Antimycobacterial and Antimicrobial Agents and Plant Elicitors Inspired by Natural Products of Insect Symbionts (GAP503/11/0616)

phytosterols, animal bile acids or on a combination of these molecules, further combined of biological activity in the nature. The target compounds bear phytosterol and/or bile acid of the molecules of bile

FR - Farmakologie a lékárnická chemie

  • 2011 - 2013
    • •
  • 12 173 tis. Kč
    • •
  • 12 173 tis. Kč
    • •
  • GA ČR
Project

Role of the Heme Oxygenase in the Pathogenesis of Cholestasis (NT11327)

serum bile acids. We have shown that taurocholic acid as a HO inhibitor might of bile acids and other factors on HO and associated cell signaling pathways contributes to the maintenance of bile f...

FE - Ostatní obory vnitřního lékařství

  • 2010 - 2013
    • •
  • 5 131 tis. Kč
    • •
  • 5 131 tis. Kč
    • •
  • MZ
Project

Prediction of termination of pregnancy in women with serious hepatopathies (NT12211)

of this model the steroid metabolome (about 100 steroids and related substances), some bile acids and further markers of ICP will be used. We will attempt to find common components of steroidogenesis and synthesis of bile ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2011 - 2015
    • •
  • 7 549 tis. Kč
    • •
  • 7 549 tis. Kč
    • •
  • MZ
Project

Bile salt malabsorption in patients with Crohn´s disease as a factor predisposing for pigment gallstone formation (NK7707)

Aim of the study is to assess the malabsorption of bile-acids in pts with Crohn´s disease as the predisposition factor of pigment cholelithiasis by detection of 7 alpha hydroxy-4-cholesten-3-ons in blood specimens.......

FP - Ostatní lékařské obory

  • 2003 - 2005
    • •
  • 1 785 tis. Kč
    • •
  • 1 746 tis. Kč
    • •
  • MZ
Project

Perspective application of xenosensor nuclear receptors ligands in therapy of cholestatic liver diseases (GA22-05167S)

and CAR have been also shown to regulate bile acid (BA) and cholesterol homeostasis on bile acid and cholesterol homeostasis using omics approaches; (ii) if novel human CAR/PXR ligands regulate bile a...

Pharmacology and pharmacy

  • 2022 - 2024
    • •
  • 12 904 tis. Kč
    • •
  • 12 856 tis. Kč
    • •
  • GA ČR
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