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905 (0,137s) •

Project

Mutants of tumor supressor protein p53 and regulation of thei DNA binding activity (KJB500040502)

p53 mutant binding properties to natural binding sequences in linear and/or acrylamide gel. We will examine the possibility of activation p53 mutants to DNA binding using specific phosphorylation, monoclonal antibodies and...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 1 230 tis. Kč
    • •
  • 1 230 tis. Kč
    • •
  • AV ČR
Project

Role of DNA conformation and DNA grooves in protein - DNA recognition. Model studies. (GA204/96/0287)

governing the specific and selective binding of proteins to DNA with a special regard of the complex. Peptides modelling the specific protein binding sites (i.e. the binding motif of the bZIP proteins), and also more simpl...

CE - Biochemie

  • 1996 - 1998
    • •
  • 747 tis. Kč
    • •
  • 480 tis. Kč
    • •
  • GA ČR
Project

Influence of DNA superhelicity on sequence specific and structure selective binding of the p53 protein (GP301/04/P025)

play crucial role in p53 protein function. DNA protein binding is often supercoiling on p53 binding allowing detail studies of binding properties to native p53 binding to sets of topoisomeric samples and compare w...

CE - Biochemie

  • 2004 - 2006
    • •
  • 720 tis. Kč
    • •
  • 720 tis. Kč
    • •
  • GA ČR
Project

Binding of tumor suppressor protein p53 to DNA. Effect of DNA supercoling and protein postsynthetic modification (IAA4004110)

protein p53 and its binding to DNA. Better understanding of this key protein binding to DNA and particularly to supercoiled DNA, (ii) the effect ofthe DNA superhelix density on p53 binding, (iii) the effect of supercoiling...

CE - Biochemie

  • 2001 - 2004
    • •
  • 4 874 tis. Kč
    • •
  • 1 990 tis. Kč
    • •
  • AV ČR
Project

Non-standard interactions between muscarinic receptors and their agonists and antagonists (GP305/01/D119)

The aim of the project is to enhance knowledge on the binding domains binding domain but also in another domain, with which it remains very firmly linked and from which it can act on the classical binding domain. In the cas...

ED - Fyziologie

  • 2001 - 2004
    • •
  • 309 tis. Kč
    • •
  • 80 tis. Kč
    • •
  • GA ČR
Project

Non-standard interactions between muscarinic receptors and their agonists and antagonists (GP305/02/D090)

The aim of the project is to enhance knowledge on the binding domains binding domain but also in another domain, with which it remains very firmly linkedand from which it can act on the classical binding domain. In the case...

ED - Fyziologie

  • 2002 - 2005
    • •
  • 687 tis. Kč
    • •
  • 687 tis. Kč
    • •
  • GA ČR
Project

Regulation of transcription factors binding to consensus sequences in superhelical DNA. Influence of phosphorylation of tumor supressor proteins (IAB5004203)

with transcription factors. In our study we wil clone natural binding sequences of p53, p73 between different natural binding sequences. We will use our new method for semiquantitative testing of the effect of the DNA supercoiling ...

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 3 400 tis. Kč
    • •
  • 1 080 tis. Kč
    • •
  • AV ČR
Project

Molecular mechanism of interaction between the H4-H5 loop of Na+/K+-ATPase and the binding site for cardiac glycosides (IAA7011801)

which is also called a receptor for cardioactive glycosides. The binding site for cardiac glycosides was revealed to be far away from the binding site for ATP. These binding sites, however, apparently cooperate. As reveale...

BO - Biofyzika

  • 1998 - 2000
    • •
  • 1 852 tis. Kč
    • •
  • 1 075 tis. Kč
    • •
  • AV ČR
Project

Seed-agnostic miRNA binding site classification (GJ19-10976Y)

Argonaute (Ago) proteins use miRNAs as driver sequences to bind specific RNAs-Seq) allow for the transcriptome-wide identification of miRNA binding sites ~60% non canonical binding. Here, we propose the production of deep c...

Biochemistry and molecular biology

  • 2019 - 2023
    • •
  • 8 750 tis. Kč
    • •
  • 8 750 tis. Kč
    • •
  • GA ČR
Project

Targeting DNA interactions with platinum anticancer drugs with damaged-DNA binding-proteins (LH13096)

with damaged-DNA binding-proteins. The major motivation for formulation of this aim the methods of molecular biophysics, biology and pharmacology: (1) Novel DNA binding modes modified by polynuclear platinum compounds and model com...

CA - Anorganická chemie

  • 2013 - 2015
    • •
  • 1 866 tis. Kč
    • •
  • 1 866 tis. Kč
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  • MŠMT
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