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52 (0,07s) •

Project

The role of mitochondrial IDH2 in bioenergetics, redox regulations, and cancer (GPP301/12/P381)

bioenergetics, with focus on glutamine-dependent reductive carboxylation pathway bioenergetics, lipid synthesis, redox homeostasis, and overall cell survival. The studywill include loss of function approach, bioenergetic s...

FD - Onkologie a hematologie

  • 2012 - 2014
    • •
  • 2 430 tis. Kč
    • •
  • 2 430 tis. Kč
    • •
  • GA ČR
Project

Investigation of the control of bioenergetic plasticity of tumor by oncogenic switches (GJ19-22156Y)

Cancer cells differ from non-tumor cells in their high bioenergetic demands and in the ways they meet these demands. Tumors show preferential metabolism of glucose via of the identified bioenergetic plasticity is thus essential for ...

Cell biology

  • 2019 - 2020
    • •
  • 2 499 tis. Kč
    • •
  • 2 499 tis. Kč
    • •
  • GA ČR
Project

IPHYS MSCA Mobility IV (EF20_079/0017164)

The project aims at implementing research projects of dr. Koňaříková and dr. Levčík. The project will further advance research in the Department of Neurophysiology of Memory and in the Department of Bioenergetics, and will disseminate knowle...

Physiology (including cytology)

  • 2020 - 2023
    • •
  • 6 094 tis. Kč
    • •
  • 1 164 tis. Kč
    • •
  • MŠMT
Project

Deciphering the role of Nrf2 in the pathophysiology of phosphomannomutase 2 deficiency (GA22-18235S)

Diseases characterized by cognitive impairment have been widely described to have dysregulated cellular bioenergetics, which is implied as a central causal various aspects of cellular bioenergetics, presumably by regulating calcium ...

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 6 247 tis. Kč
    • •
  • 6 247 tis. Kč
    • •
  • GA ČR
Project

The role of ATP synthase structure in the biogenesis and bioenergetics of the unique Trypanosoma brucei mitochondrion (GA18-17529S)

the role of these arrays in cristae structure and mt bioenergetics. However, mt bioenergetics and biogenesis in two major life stages of this parasite.......

Biochemistry and molecular biology

  • 2018 - 2022
    • •
  • 6 731 tis. Kč
    • •
  • 6 512 tis. Kč
    • •
  • GA ČR
Project

Targeting Tumor Bioenergetics for Therapeutic Intervention in Cancer (GF22-16819K)

of the central metabolic pathway mTORC1 and in bioenergetics through yet-to-unravel of Mcl-1 in the regulation of mTORC1 and bioenergetics and contribution to metastasis......

Pharmacology and pharmacy

  • 2022 - 2025
    • •
  • 6 072 tis. Kč
    • •
  • 6 072 tis. Kč
    • •
  • GA ČR
Project

Role of receptor tyrosine kinase Her2 in mitochondria (GA16-12719S)

is unknown. Our pilot data document a regulatory effect on bioenergetics. It is further on bioenergetics, the ability of Her2 to phosphorylate mitochondrial proteins and the manner......

EB - Genetika a molekulární biologie

  • 2016 - 2018
    • •
  • 6 654 tis. Kč
    • •
  • 6 543 tis. Kč
    • •
  • GA ČR
Project

RNA-demethylase FTO in the regulation of cognitive function and brain energy homeostasis a novel pharmacological target in Alzheimer's disease (GJ16-21228Y)

bioenergetics is at core of those early events. A better understanding of the links between understanding of the links between brain bioenergetics and cognitive function.......

FH - Neurologie, neurochirurgie, neurovědy

  • 2016 - 2020
    • •
  • 5 420 tis. Kč
    • •
  • 5 420 tis. Kč
    • •
  • GA ČR
Project

Dissecting a contribution of BCL-2 family proteins to mitochondrial bioenergetics (GA19-08772S)

might influence cellular bioenergetics (both glycolysis and oxidative family in bioenergetics signaling....

Cell biology

  • 2019 - 2023
    • •
  • 5 887 tis. Kč
    • •
  • 5 887 tis. Kč
    • •
  • GA ČR
Project

Nutrients from fish or nutrition for fish Unravelling hidden pollution risk and nutrient retention in fishponds by fish nutritional bioenergetics (GA22-18597S)

shifting diet scenarios may have implications on carp nutritional bioenergetics...

Water resources

  • 2022 - 2024
    • •
  • 10 688 tis. Kč
    • •
  • 10 571 tis. Kč
    • •
  • GA ČR
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