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9 451 (0,301s)

Project

Structure and dynamics of organometallic complexes in bio-environment. (GA16-06240S)

Reaction mechanisms of metal cations coordinated with oligonucleotides or fragments of peptides, and proteins (biomolecules) at molecular level helps to validate and/or predict properties and reactivity of metallocomplexes in biophysical and biochem...

CF - Fyzikální chemie a teoretická chemie

  • 2016 - 2020
  • 4 989 tis. Kč
  • 4 188 tis. Kč
  • GA ČR
Project

Ru and Rh complexes with potential biological activity (GP203/08/P436)

The success achieved by cis-[Pt(NH3)2Cl2] and related platinum complexes transition-metal complexes which could be used in cancer chemotherapy. Among them, octahedralRu-complexes have attracted large interest, and some of t...

CA - Anorganická chemie

  • 2008 - 2009
  • 1 530 tis. Kč
  • 1 530 tis. Kč
  • GA ČR
Project

Structure and Dynaics of Bioinorganic Complexes (GAP205/10/0228)

Study of structure and dynamics of metal ions coordinated with fragments of oligonucleotides, proteins and peptides (biomolecules) at the molecular level helps to verify or predict basic reaction mechanisms metallocomplexes in biophysical and biochem...

CF - Fyzikální chemie a teoretická chemie

  • 2010 - 2013
  • 4 396 tis. Kč
  • 4 396 tis. Kč
  • GA ČR
Project

Accurate theoretical modelling of redox reactivity in polynuclear non-heme iron metalloenzymes (EF18_070/0010490)

The project embodies the study of polynuclear Fe2S2 and Fe4S4 clusters, relevant for metalloenzymology, through a thermodynamic description recently proposed by our team (Proc. Natl. Acad. Sci. USA, accepted manuscript) that allows the correlation of...

Physical chemistry

  • 2019 - 2020
  • 3 266 tis. Kč
  • 3 266 tis. Kč
  • MŠMT
Project

Redox properties and reactivities of nonheme iron active sites (GJ15-10279Y)

) enzymes and their model complexes. These species are important not only due description of their complex electronic structures often complicates predictions in the realm of powerful NHFe enzymes and related bio-inspired comple...

CF - Fyzikální chemie a teoretická chemie

  • 2015 - 2017
  • 3 592 tis. Kč
  • 3 592 tis. Kč
  • GA ČR
Project

Functionalized Magnetic Carriers Based on Iron Oxide Nanoparticles with Bonded Biologically Active or Magnetically Interesting Compounds (GAP207/11/0841)

The project builds on experiences and investigator team experimental results obtained in the field of bioinorganic chemistry and nanomaterials. The project be used for bonding of biologically active complexes structurally derived fr...

CA - Anorganická chemie

  • 2011 - 2014
  • 10 020 tis. Kč
  • 6 420 tis. Kč
  • GA ČR
Project

Radical catalysis of enzymatic and biomimetic polynuclear transition-metal active sites (GA18-13093S)

Radicals generated by redox-active transition metal centers appear crucial for many vital and difficult biochemical transformations. In this proposal, we will focus on polynuclear transition-metal active sites, mostly in radical S-adenosylmethionine ...

Physical chemistry

  • 2018 - 2020
  • 4 437 tis. Kč
  • 4 161 tis. Kč
  • GA ČR
Project

Computational Design of Minimalistic Metallopeptides ‘En Route’ to Disentangling the Catalytic Power of Metalloproteins (GA14-31419S)

The aim of this project is an 'ab initio' design of both small catalytic metallopeptides and highly specific metal chelators. Thus, starting with the design of highly specific metal chelators as a proof-of-the-concept, we will climb the ladder of inc...

CF - Fyzikální chemie a teoretická chemie

  • 2014 - 2016
  • 4 008 tis. Kč
  • 4 008 tis. Kč
  • GA ČR
Project

Mono- and binuclear Fe, Cu active sites in biological systems interplay between theory and experiment (LTAUSA19148)

The aim of the project is a thorough understanding of the structure/function relationship in several mono and binuclear Fe and Cu metalloenzymes and their synthetic analogues. By correlating spectroscopic measurements carried out in the laboratory of...

Physical chemistry

  • 2020 - 2022
  • 10 355 tis. Kč
  • 8 738 tis. Kč
  • MŠMT
Project

Environment-responsive nanoparticles (IAA100500501)

complexes formed by electrostatic interactions of zwitterionic copolymers of (a) thermoresponsive supramolecular complexes formed either by hydrogen bondings between carboxylic groups of polycarboxylates or by hydrophobic ...

BJ - Termodynamika

  • 2005 - 2008
  • 1 726 tis. Kč
  • 1 726 tis. Kč
  • AV ČR
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