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531 (0,075s) •

Project

Life of a single biomolecule in a motion picture (GA22-18203S)

Numerous biomolecules and their interactions possess physiologically relevant single-molecule imaging methods, however, require fluorescent labelling or immobilization onto a surface, which might alter the biomolecule’s nat...

Optics (including laser optics and quantum optics)

  • 2022 - 2024
    • •
  • 6 840 tis. Kč
    • •
  • 6 716 tis. Kč
    • •
  • GA ČR
Project

Development of new bioorthogonal reactions (GJ15-06020Y)

Current methodologies for labeling of biomolecules have drawbacks such as: bad synthetic accessibility of starting materials, low stability of the reagents under physiological conditions, need for catalysis or formation of isomeric ...

CC - Organická chemie

  • 2015 - 2017
    • •
  • 5 716 tis. Kč
    • •
  • 5 716 tis. Kč
    • •
  • GA ČR
Project

Development of terbium-161-labelled biomolecules as theranostic tools in nuclear medicine (NU23-08-00214)

biomolecules for targeted radiodiagnostics and radiotherapy in nuclear medicine purity. The aim of this study is to develop terbium-161 labelling protocol where biomolecules. The project involved several novel anticancer m...

Pharmacology and pharmacy

  • 2023 - 2026
    • •
  • 12 656 tis. Kč
    • •
  • 12 656 tis. Kč
    • •
  • MZ
Project

Surpassing the Diffraction Limit in Label-Free Microscopy (LL2409)

In this project, I introduce the next generation of super-resolution microscopy relying on direct and label-free imaging of single-biomolecule fluctuations at high-speed to offer a complementary insight into the complex dynamics of ...

Optics (including laser optics and quantum optics)

  • 2024 - 2026
    • •
  • 24 416 tis. Kč
    • •
  • 24 416 tis. Kč
    • •
  • MŠMT
Project

Synthesis and evaluation of azaphthalocyanine derivatives as fluorescence quenchers (KJB401100801)

The project is focused on the synthesis and evaluation of a new structural type of fluorescence quenchers used in non-radiative labeling of biomolecules. Fluorescence labeling is widely used method for biomolecule ...

CC - Organická chemie

  • 2008 - 2010
    • •
  • 2 327 tis. Kč
    • •
  • 2 327 tis. Kč
    • •
  • AV ČR
Project

Dioscuri Centre for Single-Molecule Optics (LV23028)

Biomolecules are the fundamental building blocks of every organism. Yet roadblocks in, for example, medical research. Biomolecules possess heterogeneities and require fluorescent labelling or immobilization onto a surface, ...

Optics (including laser optics and quantum optics)

  • 2024 - 2029
    • •
  • 38 860 tis. Kč
    • •
  • 35 874 tis. Kč
    • •
  • MŠMT
Project

Labelling of monoclonal antibodies with At-211 for targeted cancer therapy (KJB4048302)

of the product, and the investigation of several labelling methods for astatination of a model monoclonal antibody and their comparison with respect to the labelling yield......

CH - Jaderná a kvantová chemie, fotochemie

  • 2003 - 2005
    • •
  • 1 656 tis. Kč
    • •
  • 1 336 tis. Kč
    • •
  • AV ČR
Project

Multidimensional chromatography - mass spectrometry quantitative workflows in detailed characterization of human plasma lipidome (GA21-20238S)

Lipids are important biomolecules with various functions in cell membranes plasma using two complementary approaches based on 13C stable isotope labeling, such as internal standards biosynthetized from human cell lines in labele...

Analytical chemistry

  • 2021 - 2023
    • •
  • 9 310 tis. Kč
    • •
  • 9 310 tis. Kč
    • •
  • GA ČR
Project

Labelling of proteins with quantum dots and their sensing using microfluidic system (GP13-20303P)

dots (QDs) seem to show the greatest promise as labels for tagging and imaging observations of biomolecules. The proposal project is aimed at research of QDs biotin to provide biotinylated QDs which can be employed in specific ...

CE - Biochemie

  • 2013 - 2017
    • •
  • 2 161 tis. Kč
    • •
  • 2 161 tis. Kč
    • •
  • GA ČR
Project

Development of spectroscopic methods for structural studies of biomolecules (LH11033)

the mouse prion protein 5) Synthesis and measurement of selected isotopically-labeled...

CF - Fyzikální chemie a teoretická chemie

  • 2011 - 2014
    • •
  • 3 312 tis. Kč
    • •
  • 3 312 tis. Kč
    • •
  • MŠMT
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