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842 (0,106s) •

Project

Estimation of occurence of brain metastasis based on gene and protein expression profile in primary non small cell lung cancer (NS10259)

system is effective in reducing the occurrence of brain metastasis in leukemias NSCLC tumors could predict brain metastasis. The expression of candidate genes expression and the occurrence of brain me...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 2 177 tis. Kč
    • •
  • 1 998 tis. Kč
    • •
  • MZ
Project

The Value of Systematic Mediastinal Lymphadenectomy in Surgery of Lung Metastasis (NS10095)

The aim of our work is evaluation of lymph node metastasis rate by pulmonary metastasis. We will evaluate goups of patients with pulmonary metastasis of carcinoma with and without lymph node metastasis in the both ...

FJ - Chirurgie včetně transplantologie

  • 2008 - 2011
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  • 3 748 tis. Kč
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  • 3 688 tis. Kč
    • •
  • MZ
Project

Neoadjuvant Stereotactic Radiotherapy for Brain Metastasis - prospective trial NeoSTROBE (NW25-03-00278)

The main methods of treatment for brain metastases are radiotherapy and surgical resection. Among the radiation techniques, whole brain radiotherapy (WBRT) and targeted stereotactic radiotherapy (SRT) are used. In patients with meta...

Oncology

  • 2025 - 2028
    • •
  • 11 980 tis. Kč
    • •
  • 11 980 tis. Kč
    • •
  • MZ
Project

Elucidating the relationship between Trop2 expression and metastasis in cancer (GA24-11793S)

for Triple Negative Breast Cancer therapy. Although Trop2's role in metastasis remains the context-dependent role of Trop2 in metastasis, the paradox of Trop2 in primary tumor to elucidate the functional significance of Trop2 and i...

Pathology

  • 2024 - 2026
    • •
  • 9 360 tis. Kč
    • •
  • 9 221 tis. Kč
    • •
  • GA ČR
Project

Strategies for specific targeting of brain metastasis microenvironment for diagnostic and therapy (NU22-03-00318)

Brain metastases affect approximately 20% of patients with various solid the hypothesis that FAP is a potential diagnostic and therapeutic target in brain metastases. We will determine the quantity and localization of FAP in bra...

Radiology, nuclear medicine and medical imaging

  • 2022 - 2025
    • •
  • 12 326 tis. Kč
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  • 12 326 tis. Kč
    • •
  • MZ
Project

The role of p53 DNA structure-selective binding in brain cancer (GAP301/10/2370)

Brain tumors are highly invasive types of cancer. The inactivation of specific genes together with point mutation in tumor suppressor Tp53 gene portends poor prognosis and dismal survival. Mutant p53 proteins acquire a -gain of function- act...

EB - Genetika a molekulární biologie

  • 2010 - 2012
    • •
  • 1 757 tis. Kč
    • •
  • 1 757 tis. Kč
    • •
  • GA ČR
Project

Evaluation of novel potential targets and inhibitors to block metastasis development in luminal A breast cancer (GA17-05957S)

profiles, the mechanisms associated with lymph node and distant metastasis therapy against metastasis development....

CE - Biochemie

  • 2017 - 2019
    • •
  • 7 170 tis. Kč
    • •
  • 6 747 tis. Kč
    • •
  • GA ČR
Project

Crosstalk of CAS/BCAR1 and PKN3 signaling in invasiveness and metastasis of cancer cells (GA15-17419S)

and metastasis. Among other important interacting proteins we identified a PKN3 kinase. PKN3 shown to have important role in invasiveness and metastasis of prostate and breast......

FD - Onkologie a hematologie

  • 2015 - 2019
    • •
  • 5 479 tis. Kč
    • •
  • 5 479 tis. Kč
    • •
  • GA ČR
Project

Drug repurposing for anti-invasive anti-metastatic treatment - the pipeline development and elucidation of mechanisms (GA24-11903S)

Development of solid tumours is accompanied by invasion and metastasis partial control of solid cancer and do not prevent metastasis. Specific targeting invasiveness to prevent metastasis without necessarily affecting tumou...

Oncology

  • 2024 - 2026
    • •
  • 12 408 tis. Kč
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  • 12 408 tis. Kč
    • •
  • GA ČR
Project

Comparison of expression of VEGF, TGF, IL6, IL10 and bounding proteins in oropharyngeal cancers and their metastasis with those in chronic tonsillitis (NC7487)

Quantification of expression of cytokines VEGF, TGF, HGF, IL-6 and IL-10 as a disease prognostic factor - graiding of oropharyngeal carcinoma. The prove of correlation between expression of VEGF, TGF, HGF, IL-6, IL-10 and bounding proteins in primary...

FF - ORL, oftalmologie, stomatologie

  • 2003 - 2005
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  • 2 784 tis. Kč
    • •
  • 2 771 tis. Kč
    • •
  • MZ
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