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1 930 (0,193s) •

Project

The role of c-myb gene in the early vertebrate embryogenesis (GA304/03/0463)

The transcription factor c-Myb is one of key regulators of the definitive hematopoiesis in vertebrates. There are no data about the possible function of c-Myb in the early embryogenesis. Recently, we have found tha...

EA - Morfologické obory a cytologie

  • 2003 - 2005
    • •
  • 3 993 tis. Kč
    • •
  • 3 993 tis. Kč
    • •
  • GA ČR
Project

c-Myb and its transcriptional program in physiological and pathological osteogenic processes (NV18-07-00073)

. The c-Myb protein has been associated with control of these processes. Aberrant activation of c-Myb disturbs the balance in favor of proliferation and survival, thus contributing to malignant transformation. Our ...

Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

  • 2018 - 2021
    • •
  • 11 352 tis. Kč
    • •
  • 11 352 tis. Kč
    • •
  • MZ
Project

Novel functions of c-Myb during intramembranous bone formation analyzing molecular interactions in craniofacial morphogenesis (GJ19-15272Y)

The c-Myb transcription factor is associated with maintaining project aims to unravel the mechanisms of the newly described role of c-Myb and localisation of c-Myb expression in vivo. The research...

Developmental biology

  • 2019 - 2023
    • •
  • 4 720 tis. Kč
    • •
  • 4 720 tis. Kč
    • •
  • GA ČR
Project

Ultrastructural analysis of the interactions of v-Myb and c-Myb oncoproteins with nuclear matrix , chromatin nucleolar components (GA204/97/0914)

of myb gene products with isolated biological macromolecules and isolated cellular structures. This will contribute to better understanding of the mechanism of v-myb oncogeneand c-myb proto-oncogene action in the ...

EB - Genetika a molekulární biologie

  • 1997 - 1999
    • •
  • 2 430 tis. Kč
    • •
  • 1 120 tis. Kč
    • •
  • GA ČR
Project

The study of satellite cells migration (GAP305/10/2133)

line we observed that cell migration correlates with upregulation of the c-Myb transcriptional regulator. c-Myb has been previously implicated in migration of neural crest pluripotent cells. These findings support...

EB - Genetika a molekulární biologie

  • 2010 - 2014
    • •
  • 2 690 tis. Kč
    • •
  • 2 690 tis. Kč
    • •
  • GA ČR
Project

The role of c-Myb and Cox-2 proteins in colon carcinogenesis (GA301/09/1115)

Colon carcinomas are frequent malignant tumors in the Czech Republic. c-Myb to apoptosis-inducing agents. Aim of this project is to clarify the role of c-Myb and Cox-2 with up- and down-regulated expression of the ...

FD - Onkologie a hematologie

  • 2009 - 2012
    • •
  • 3 915 tis. Kč
    • •
  • 3 915 tis. Kč
    • •
  • GA ČR
Project

Position of V-Myb Oncogene and C-Myb Proto-Oncogene in the Signalling Network of Haematopoietic Cells in Differentiation and Leukaemogenesis (GA204/93/0324)

9H - 9

  • 1993 - 1995
    • •
  • 500 tis. Kč
    • •
  • 1 000 tis. Kč
    • •
  • GA ČR
Project

Ultrastructural Characterization of Interactions of V-Myb Oncogene and C-Myb Proto-Oncogene Products with Biological Macromolecules and Cell Structures (GA304/93/0210)

9H - 9

  • 1993 - 1995
    • •
  • 450 tis. Kč
    • •
  • 900 tis. Kč
    • •
  • GA ČR
Project

Molecular analysis of proliferation and leukaemogenesis induced by v - Myb oncoprotein (GA204/97/1146)

The proto-oncogene c-myb as well as its oncogenic variant v-myb gene encode proteins which play a significant part in regulation of haematopoiesis. c-myb participates in maintaining pools of immature stage...

EB - Genetika a molekulární biologie

  • 1997 - 1999
    • •
  • 4 658 tis. Kč
    • •
  • 2 608 tis. Kč
    • •
  • GA ČR
Project

c-Myb-regulated inflammatory circuit in basal-like mammary tumors (GJ17-08985Y)

metastatic mammary cells and repressed upon overexpression of transcription factor c-Myb. We propose to investigate how this transcriptional module regulated by c-Myb in tumor-stroma cross-talk in metastasis. We p...

EB - Genetika a molekulární biologie

  • 2017 - 2021
    • •
  • 4 659 tis. Kč
    • •
  • 4 659 tis. Kč
    • •
  • GA ČR
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