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53 (0,076s) •

Project

Mechanisms underlying modulation of immune cell functions by cAMP (GA310/08/0447)

This project aims at deciphering the signaling pathways by which cAMP modulates immune system functions and provokes impairment of anti bacterial immunity. We found that elevation of cytosolic cAMP in macrophages causes rapid disorg...

EC - Imunologie

  • 2008 - 2012
    • •
  • 10 247 tis. Kč
    • •
  • 10 247 tis. Kč
    • •
  • GA ČR
Project

Using phosphodiesterases to therapeutical manipulation of bone and cartilage cells (NU21-06-00512)

Cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) are used as second messengers by many signaling pathways. In bone, cAMP mediates and endochondral ossification. In addition, decrease of cAMP l...

Orthopaedics

  • 2021 - 2025
    • •
  • 11 082 tis. Kč
    • •
  • 11 027 tis. Kč
    • •
  • MZ
Project

Surviving Theresienstadt The Social Structure of a Nazi Ghetto (GA19-05523S)

thousand were sent to extermination camps. We will use individual-level data on all prisoners of the camp to model the competing risks of these two outcomes. Our aim prisoner status, over the varying survival pressure induced by

History (history of science and technology to be 6.3, history of specific sciences to be under the respective headings)

  • 2019 - 2023
    • •
  • 2 047 tis. Kč
    • •
  • 2 047 tis. Kč
    • •
  • GA ČR
Project

The Late Pliocene lower vertebrates (fishes and frogs) from the konservat-lagerstätte Camp dels Ninots (north-eastern Spain) (GA21-33751S)

The Late Pliocene (ca 3.2 Ma) locality of Camp dels Ninots (Caldes de Malavella, Spain) preserves deposits of a maar lake containing exceptionally preserved fossil remains of mammals, reptiles, amphibians, fishes, insects and plants. Despite...

Paleontology

  • 2021 - 2024
    • •
  • 3 629 tis. Kč
    • •
  • 3 629 tis. Kč
    • •
  • GA ČR
Project

Adjuvant and immunotherapeutic properties of Bordetella pertussis adenylate cyclase toxin (GP310/09/P582)

to modulate Tcell-mediated immune responses. The adjuvant nature of cAMP signalling properties of CyaA-mediated cAMP signalling and bypass its possible toxic effects in vivo. ......

EC - Imunologie

  • 2009 - 2011
    • •
  • 2 049 tis. Kč
    • •
  • 2 049 tis. Kč
    • •
  • GA ČR
Project

Deceased unfree labour forces in the area of the uranium ore production 1946-1986 (GA409/09/1742)

and inmates of hard labour camps, which were established pursuant to the Act No. 247/48 Coll., on the hard labour camps. The German prisoners of war were sent to hard labour camps in the uranium areas existed in 1949-1951....

AB - Dějiny

  • 2009 - 2011
    • •
  • 527 tis. Kč
    • •
  • 527 tis. Kč
    • •
  • GA ČR
Project

Immunomodulatory activity of adenosine receptor systém and its role in immunobiological effects of antiviral acyclic nucleoside phosphonates (GA305/03/1470)

The project is focused on the interference of adenosine/cAMP pathways with adaptive immune activity, with emphasis on production of soluble mediators that are intimately involved in immunity of infections. Namely, the effects on constitutive...

FR - Farmakologie a lékárnická chemie

  • 2003 - 2005
    • •
  • 3 395 tis. Kč
    • •
  • 3 395 tis. Kč
    • •
  • GA ČR
Project

Creating a 'Gulag' model in Virtual and Augmented Reality as a Tool for Increasing the Effectiveness of Teaching 20th-century history (TL03000574)

The main aim of the project is to create a learning model based on virtual 3D visualization of the gulag camp and via its didactic application to increase the efficiency and attractiveness of teaching the 20th-century history. It is subjecte...

Education, general; including training, pedagogy, didactics [and education systems]

  • 2020 - 2023
    • •
  • 6 368 tis. Kč
    • •
  • 4 780 tis. Kč
    • •
  • TA ČR
Project

Intracellular mechanisms of entrainment of circadian rhythm of vasopressin release from cultured suprachiasmatic neurons by VIP and melatonin. (ME 158)

. Paralelly their effects on intracellular second messengers will be measured: cAMP, cGMP laboratory, while cAMP, cGMP and calcium measurements will be done in Prague.We also......

FH - Neurologie, neurochirurgie, neurovědy

  • 1998 - 2000
    • •
  • 1 124 tis. Kč
    • •
  • 679 tis. Kč
    • •
  • MŠMT
Project

Mechanism of melatonin action in suprachiasmatic nucleus (GA309/96/0682)

)-sensitive G-protein to decrease cAMP accumulation or intracellular calcium concentration effect on cAMP accumulation and on (Ca 2+) in the cultured CSN neurons......

ED - Fyziologie

  • 1996 - 1998
    • •
  • 2 476 tis. Kč
    • •
  • 1 383 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 53