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1 096 (0,076s) •

Project

Molecular Mechanism of Cannabinoid Receptor 1 Signaling Modulation by SGIP1 (GA16-24210S)

in synaptic functions. Synaptic plasticity mediated by the endogenous cannabinoid system involves the activation of the Cannabinoid Receptor 1 (CB1R). The principles of CB1R the Src homology 3-domain growth factor rece...

FR - Farmakologie a lékárnická chemie

  • 2016 - 2020
    • •
  • 9 453 tis. Kč
    • •
  • 8 229 tis. Kč
    • •
  • GA ČR
Project

Role of proteins associated with Cannabinoid receptor CB1 in trafficking (IAA500390701)

of the endogenous cannabinoid system at the molecular, cellular, pharmacological and physio, partner-proteins of CB1R are unknown. Lateral dynamic of postsynaptic receptors has that neurotransmitter receptor movement into ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2007 - 2011
    • •
  • 7 899 tis. Kč
    • •
  • 7 899 tis. Kč
    • •
  • AV ČR
Project

The role of SGIP1 in modulation of nociception via Cannabinoid receptor 1 (GA21-02371S)

Treatment of chronic pain, one of the most fundamental tasks of medicine, is often not satisfactorily achieved. Cannabinoid receptor 1 (CB1R) was identified as a promising target for pain therapy. We have previously described modula...

Neurosciences (including psychophysiology)

  • 2021 - 2023
    • •
  • 5 901 tis. Kč
    • •
  • 5 901 tis. Kč
    • •
  • GA ČR
Project

Effects of perioperative opioid analgesia on circulating tumor cells in colorectal cancer multicenter randomized clinical trial (NV18-03-00470)

, including analysis of opioid and cannabinoid receptor subtypes in cancer tissue. 2. PRMT of opioid and cannabinoid receptor subtypes in cancer tissue.......

Oncology

  • 2018 - 2022
    • •
  • 15 056 tis. Kč
    • •
  • 14 993 tis. Kč
    • •
  • MZ
Project

Role of the orbitofrontal cortex, and its modulation by endocannabinoids, in social withdrawal in schizophrenia (GA22-06943S)

symptoms of the disease, resulted from a lack of cannabinoid CB1 receptor stimulation by cannabinoids. In this project, we will combine in vivo electrophysiology and behavioral......

Neurosciences (including psychophysiology)

  • 2022 - 2024
    • •
  • 9 183 tis. Kč
    • •
  • 9 183 tis. Kč
    • •
  • GA ČR
Project

Novel CB2 and BChE modulators against Parkinson's disease and related pathologies (GA23-05389S)

Parkinson's disease is one of the growing problems in the senior population of developed countries. In this project, we intend to investigate novel purine derivatives targeting both cannabinoid receptor 2 (CB2) and butyrylcholineste...

Biochemistry and molecular biology

  • 2023 - 2025
    • •
  • 9 897 tis. Kč
    • •
  • 9 897 tis. Kč
    • •
  • GA ČR
Project

Combination of new cannabinoids and advanced formulation methods for treatment of rheumatoid arthritis (NU22-08-00346)

efficacious and tolerable agents. Cannabidiol and some other CB2 receptor agonists have (emulsion-based and cocrystals) containing strong CB2 agonist cannabinoids (cannabidiol CB2 receptor agonists MDA 19 and L-759633, not...

Pharmacology and pharmacy

  • 2022 - 2025
    • •
  • 14 344 tis. Kč
    • •
  • 14 344 tis. Kč
    • •
  • MZ
Project

Selective regulation of presynaptic neurotransmitter receptors by SGIP1 (GA19-24172S)

Cannabinoid receptor 1 (CB1R) and mu-Opioid receptors (MOR) are physiologically important and pharmacologically relevant receptors that partially co-localize pre growth factor receptor-bound 2-like (endoph...

Neurosciences (including psychophysiology)

  • 2019 - 2023
    • •
  • 7 162 tis. Kč
    • •
  • 6 427 tis. Kč
    • •
  • GA ČR
Project

Nanofibre mesh with the admixture of cannabinoids for the treatment of wounds after extensive surgery (FV30362)

The object of the project is the research and realization of mesh (grid) based on nanofiber blended with cannabinoids. The main objective of the project is to optimize the technological process and production technology nets for therapeutic ...

Transplantation

  • 2018 - 2022
    • •
  • 18 096 tis. Kč
    • •
  • 12 656 tis. Kč
    • •
  • MPO
Project

Anorexia nervosa and bulimia nervosa, search for new clinical subtypes and their correlation with polymorphisms in selected genes. (NS10045)

,personality and autoaggressive factors: serotonin, dopamin and cannabinoid receptors; arginine vasopressin 1a receptor, COMT and polymorphisms within nNOS.......

FL - Psychiatrie, sexuologie

  • 2008 - 2011
    • •
  • 6 799 tis. Kč
    • •
  • 6 599 tis. Kč
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  • MZ
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