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43 (0,127s) •

Project

Study of relationships between structure and function of phenotypically relevant mutants of Mason-Pfizer monkey virus matrix protein (GA203/03/0490)

andplays a key role in the process of capsid assembly. It is responsible for assembly or for transport of capsids to the plasma membrane. Structural analysis) preventing the transport of capsids to the plasma membrane, and...

CE - Biochemie

  • 2003 - 2005
    • •
  • 5 104 tis. Kč
    • •
  • 3 346 tis. Kč
    • •
  • GA ČR
Project

Structural and functional study of matrix protein and proteinaseof monkey immunosuppressive retrovirus (GA203/97/0416)

model system for its intracytoplasmic assembly of capsid shell. A point mutation-type (e.g. HIV-1) which assembles its capsids at the plasma membrane. Therefore of retroviral capsid assembly. Matrix gene will be cloned and...

CE - Biochemie

  • 1997 - 1999
    • •
  • 2 843 tis. Kč
    • •
  • 1 809 tis. Kč
    • •
  • GA ČR
Project

Study of inhibition of multimerization of retroviral capsid protein from HIV-1 (IAB4055202)

The aim is to develop an assay for testing inhibitors of dimerization of capsid proteins (CA). CA, as a part of Gag polyproteins plays a crucial role in assembly of innature capsids mediating the Gag-Gag interactions. CA dimerisatio...

CE - Biochemie

  • 2002 - 2004
    • •
  • 1 879 tis. Kč
    • •
  • 1 403 tis. Kč
    • •
  • AV ČR
Project

Biocompatibilization and Targeting of Nanoparticles for Diagnostic and Therapeutic Applications (LH11027)

The objective of project is i) design and preparation of a new biocompatible surfaces on nanoparticles (virus-like capsids, fluorescence nanodiamonds, magnetic nanoparticles), ii) development of synthetic methodology for their funcionalizati...

CC - Organická chemie

  • 2011 - 2014
    • •
  • 3 440 tis. Kč
    • •
  • 3 440 tis. Kč
    • •
  • MŠMT
Project

Development of diagnostic components and adaptable technology of preparation of recombinant vaccines based on capsid nanostructures of the mouse polyomavirus. (TA03010700)

will be created. Fortheir preparation, artificial empty virus capsids (VLPs - virus like particles) and stabile chimeric nanostructures derived from mouse polyomavirus capsids......

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2013 - 2016
    • •
  • 18 614 tis. Kč
    • •
  • 12 089 tis. Kč
    • •
  • TA ČR
Project

Structural study of protein domains of monkey retrovirus (IAA4055304)

Temporal and spatial separation of assembly of immature capsid particles from their release makes Mason-Pfizer monkey virus (M-PMV), inducing an AIDS like syndrom in non-human primates, an attractive experimental model for the study of retro...

CE - Biochemie

  • 2003 - 2007
    • •
  • 11 354 tis. Kč
    • •
  • 4 282 tis. Kč
    • •
  • AV ČR
Project

In vitro preparation of recombinant capsids for nucleic acids incorporation and internalization in the cell tissue (GP203/03/P094)

of capsid assembly and mechanism of infections can significantly contribute to better will further study binding of nucleic acids to proteins forming viral capsids. Our goal......

EE - Mikrobiologie, virologie

  • 2003 - 2005
    • •
  • 750 tis. Kč
    • •
  • 750 tis. Kč
    • •
  • GA ČR
Project

Structual antigens of papovaviruses fuctions , cellular interactions and utilisation for gene therapy purposes (GA204/96/0256)

artificially made papovavirus empty capsid-like particlaes. Th egreat advantage of these DNA transfer vehicles would be that capsid-like particles produced by self preliminary experiments we have shown that artificial capsid

EB - Genetika a molekulární biologie

  • 1996 - 1998
    • •
  • 3 048 tis. Kč
    • •
  • 2 567 tis. Kč
    • •
  • GA ČR
Project

Structural study of protein p12 from Mason-Pfizer monkey virus using NMR spectroscopy (GP203/02/P098)

, p27 (capsid protein - CA), p14 (nucleocapsid protein - NC) and p4. The functions, that this protein supports the assembly of immature viral capsid. The aim of this project be utilized for a design of suitable inhibitor or viral

CE - Biochemie

  • 2002 - 2004
    • •
  • 359 tis. Kč
    • •
  • 209 tis. Kč
    • •
  • GA ČR
Project

The construction of retroviral particles with their potential use as a therapeutic delivery systems (KJB501270701)

The part of structural polyprotein precursor Gag of Mason-Pfizer monkey virus (M-PMV), namely mutated fusion capsid and nucleocapsid protein ((pro-)CANC), is able to form spherical particles in vitro with the ability to incorporate nucleic a...

EE - Mikrobiologie, virologie

  • 2007 - 2009
    • •
  • 1 209 tis. Kč
    • •
  • 1 209 tis. Kč
    • •
  • AV ČR
  • 1 - 10 out of 43