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2 454 (0,223s) •

Project

The construction of retroviral particles with their potential use as a therapeutic delivery systems (KJB501270701)

(M-PMV), namely mutated fusion capsid and nucleocapsid protein ((pro-)CANC and the presence of nucleic acids. The goal of this project is optimization of M-PMV capsid formation at various conditions and study of the role o...

EE - Mikrobiologie, virologie

  • 2007 - 2009
    • •
  • 1 209 tis. Kč
    • •
  • 1 209 tis. Kč
    • •
  • AV ČR
Project

The analysis of molecular organization of the retrovirus particle and interactions leading to its assembly (ME 904)

The aim is to employ a multi-methodical approach to study various aspects of formation of retroviral particles. This will be made possible by the employment. Hunter resides in a multi-methodical approach to the study of the mechanism of ...

EE - Mikrobiologie, virologie

  • 2007 - 2011
    • •
  • 2 391 tis. Kč
    • •
  • 2 391 tis. Kč
    • •
  • MŠMT
Project

Structural and functional study of matrix protein and proteinaseof monkey immunosuppressive retrovirus (GA203/97/0416)

the myristylation of MA is required for capsid formation, the effect of this modification model system for its intracytoplasmic assembly of capsid shell. A point mutation-type (e.g. HIV-1) which assembles its capsids

CE - Biochemie

  • 1997 - 1999
    • •
  • 2 843 tis. Kč
    • •
  • 1 809 tis. Kč
    • •
  • GA ČR
Project

Study of inhibition of multimerization of retroviral capsid protein from HIV-1 (IAB4055202)

The aim is to develop an assay for testing inhibitors of dimerization of capsid proteins (CA). CA, as a part of Gag polyproteins plays a crucial role in assembly of innature capsids mediating the Gag-Gag interactions. CA dimerisatio...

CE - Biochemie

  • 2002 - 2004
    • •
  • 1 879 tis. Kč
    • •
  • 1 403 tis. Kč
    • •
  • AV ČR
Project

Study of structure and interactions critical for formation of immature retroviral particles for testing and rational design of HIV assembly inhibitors (GA14-15326S)

that rearrange into mature, infectious particle. Immature particle formation is mediated) of capsid protein (CA) as well as nucleocapsid protein and nucleic acids. This proposal critical for formation of immature and matur...

EE - Mikrobiologie, virologie

  • 2014 - 2016
    • •
  • 6 285 tis. Kč
    • •
  • 6 285 tis. Kč
    • •
  • GA ČR
Project

Study of the role of capsid protein in early phase of HIV-1 replication cycle using the newly identified compounds stabilizing capsid complexes (GA17-25602S)

Interactions mediating oligomerization of retroviral capsid protein (CA) are critical both for formation and dissociation of viral core. The core dissociation (uncoating) is critical for following early processes: reverse transcript...

EE - Mikrobiologie, virologie

  • 2017 - 2019
    • •
  • 5 271 tis. Kč
    • •
  • 4 929 tis. Kč
    • •
  • GA ČR
Project

Structure and assembly of retroviral proteins - specific domains responsible for these processes (GA203/00/1005)

The mechanism of retroviral capsid formation is still poorly understood despite the extensive scientific effort aimed at these steps in HIV. The inhibition of any step in assembly and intracellular transport of viral proteins would ...

CE - Biochemie

  • 2000 - 2002
    • •
  • 2 415 tis. Kč
    • •
  • 2 115 tis. Kč
    • •
  • GA ČR
Project

Study of interactions of biological macromolecules and nanolayers with a view to research of polymer microfluidic biosensors and therapeutic nanoparticles (KAN208240651)

of macromolecular nanostructures, protein nanolayers and retroviral capsids for diagnostic chips, formation of biologically active nanolayers and internal structures of chips......

CI - Průmyslová chemie a chemické inženýrství

  • 2006 - 2010
    • •
  • 19 997 tis. Kč
    • •
  • 17 458 tis. Kč
    • •
  • AV ČR
Project

Study of relationships between structure and function of phenotypically relevant mutants of Mason-Pfizer monkey virus matrix protein (GA203/03/0490)

andplays a key role in the process of capsid assembly. It is responsible for assembly or for transport of capsids to the plasma membrane. Structural analysis) preventing the transport of capsids to the plasma membrane, and...

CE - Biochemie

  • 2003 - 2005
    • •
  • 5 104 tis. Kč
    • •
  • 3 346 tis. Kč
    • •
  • GA ČR
Project

Biocompatibilization and Targeting of Nanoparticles for Diagnostic and Therapeutic Applications (LH11027)

The objective of project is i) design and preparation of a new biocompatible surfaces on nanoparticles (virus-like capsids, fluorescence nanodiamonds, magnetic nanoparticles), ii) development of synthetic methodology for their funcionalizati...

CC - Organická chemie

  • 2011 - 2014
    • •
  • 3 440 tis. Kč
    • •
  • 3 440 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 2 454