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965 (0,071s) •

Project

The role of hepcidin in regulation of systemic and myocardial iron metabolism in heart failure (GA15-14200S)

and cardiac iron deficiency in heart failure are unknown. Tissue and body iron regulationIron deficiency is observed in 50 percent of patients with heart failure. The deficiency is not only implicated in development of ane...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2015 - 2019
    • •
  • 9 655 tis. Kč
    • •
  • 9 655 tis. Kč
    • •
  • GA ČR
Project

The interaction between renin-angiotensin and endothelin systems in the pathogenesis of renal failure and cardiac hypertrophy in hypertensive rats (NS10500)

Potential additive effect of the treatment wirh endothelin receptor blocker (atrasentan) to low salt diet and renin-angiotensin system blockade in a rat model transenic for mouse renin gene and/or 5/6 nephrectomy will be studied. The aim is to furthe...

FE - Ostatní obory vnitřního lékařství

  • 2009 - 2011
    • •
  • 3 942 tis. Kč
    • •
  • 3 942 tis. Kč
    • •
  • MZ
Project

Cardiac resynchronization therapy in early postoperative period after cardiac surgery (NR9384)

The purpose of this research project is to conduct a prospective randomized clinical trial to evaluate the effect of biventricular pacing and left-ventricle targeted resynchronization therapy in the patients with left ventricle dysfunction during ear...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2007 - 2010
    • •
  • 2 940 tis. Kč
    • •
  • 2 878 tis. Kč
    • •
  • MZ
Project

Cardiac resynchronization therapy in patients with congenital heart disease. (NA7620)

Cardiac resynchronization therapy as a new method for the treatment of chronic heart failure in patients with congenital heart disease and atrioventricular and/or intraventricular conduction delay. Technical aspects and acute and mi...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2003 - 2005
    • •
  • 1 458 tis. Kč
    • •
  • 1 224 tis. Kč
    • •
  • MZ
Project

Clinical significance of collagen metabolism changes in patients with failing and pressure overloaded left cardiac ventricle. (NR9022)

The study will verify the hypothesis that the changes in cardiac collagen metabolism detected by serum markers could predict the remodelation of left ventricle and prognosis in patients with significantly pressure overloaded left cardiac...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2006 - 2008
    • •
  • 1 298 tis. Kč
    • •
  • 1 176 tis. Kč
    • •
  • MZ
Project

Investigation of metabolic mechanisms of heart failure progression in an experimental model (GA305/09/1390)

cardiac substrate metabolism, particularly insulin resistance, increased fat tissue in the progression of chronic heart failure (CHF). Proposed research project aims to study relationships among metabolic alterations, cardiac

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2009 - 2012
    • •
  • 8 651 tis. Kč
    • •
  • 8 651 tis. Kč
    • •
  • GA ČR
Project

Electrical activation of the left ventricular myocardium by application of modified epicardial triventricular system for cardiac resynchronization therapy of heart failure (NV18-02-00080)

Cardiac resynchronization therapy (CRT) is an established part of management in patients with heart failure and wide QRS. Clinical studies have demonstrated its capacity to improve quality of life, morbidity and mortality. Neverthel...

Cardiac and Cardiovascular systems

  • 2018 - 2022
    • •
  • 6 958 tis. Kč
    • •
  • 6 864 tis. Kč
    • •
  • MZ
Project

Use of extracorporeal membrane oxygenation /ECMO/ in the therapy of respiratory and cardiac failure not responsive to other therapeutical possibilities / neonat (IZ1452)

9F - 9

  • 1993 - 1995
    • •
  • 3 850 tis. Kč
    • •
  • 7 700 tis. Kč
    • •
  • MZ
Project

Mutations of ryanodine receptor in relationship to malignant arrhythmias and sudden cardiac death in patients with heart failure (2B08061)

The aim of the project is to contribute to better understanding of sudden cardiac death pathophysiology. The study population will consist of high risk patients with heart failure who survived malignant ventricular arrhythmia. In th...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2008 - 2011
    • •
  • 7 594 tis. Kč
    • •
  • 6 651 tis. Kč
    • •
  • MŠMT
Project

New techniques of hemodynamically optimized temporary cardiac pacing after surgery for congenital heart defects. (NA5930)

Use and validation of new techniques of temporary cardiac pacing in children after surgery for congenital heart defects, who suffer from low cardiac output and hemodynamically significant dysrhythmias. Evaluation of hemodynamic bene...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2000 - 2002
    • •
  • 821 tis. Kč
    • •
  • 821 tis. Kč
    • •
  • MZ
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