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23 (0,097s) •

Project

The Assessment of Late Doxorubicin-Induced Cardiotoxicity in Adults Treated for Malignant Lymphoma (NC7354)

The assessment of clinical value of early changes of LV function during the treatment for late onset of cardiotoxicity. The assessment of the incidence of late cardiotoxicity 5-7 yrs after the chemotherapy. The assessment of the con...

FC - Pneumologie

  • 2003 - 2005
    • •
  • 1 476 tis. Kč
    • •
  • 1 468 tis. Kč
    • •
  • MZ
Project

Roles of oxidative stress and antioxidative systems in antracycline induced chronic cardiotoxicity in adult patients. (NS9774)

Aim of this study is to evaluate the role of oxidative stress ( level of oxidative stress, major antioxidative enzymes´ activity, gene polymorphisms for major antioxidative enzymes ) in anthracycline induced chronic cardiotoxicity in the cli...

FD - Onkologie a hematologie

  • 2008 - 2011
    • •
  • 5 397 tis. Kč
    • •
  • 5 163 tis. Kč
    • •
  • MZ
Project

Anthracycline cardiotoxicity – new possibilities of pharmacological cardioprotection and risks of combination with biological targeted anticancer treatment (NT13457)

to reduce risks of anthracycline cardiotoxicity, although data from complex experimental will be revealed. The risk of cardiotoxicity can be markedly increased by combination on impact of bortezomib on anthracycline cardiotoxic...

FR - Farmakologie a lékárnická chemie

  • 2012 - 2015
    • •
  • 6 320 tis. Kč
    • •
  • 6 320 tis. Kč
    • •
  • MZ
Project

Differential diagnosis of cardiomypathy and cardiotoxicity in oncologic patients based on innovative molecular-diagnostic platforms (FW03010174)

The aim of this project is to develop a modern diagnostic method for differential diagnosis of cardiomyopathy associated with cardiotoxicity of cytostatic treatment in oncological patients based on molecular-genetic approaches (Two tailed PC...

Health-related biotechnology

  • 2021 - 2025
    • •
  • 34 472 tis. Kč
    • •
  • 22 515 tis. Kč
    • •
  • TA ČR
Project

Myocardial damage induced by anticancer drugs and ischemia-reperfusion new possibilities of pharmacological cardioprotection. (GA305/09/0416)

Cardiotoxicity of anticancer drugs and ischemia-reperfusion (I/R) rank among) and anthracycline (ANT) cardiotoxicity. Recent in vitro data suggested protective potential of pharmacodynamics of cardioprotective effects of DEX against...

FR - Farmakologie a lékárnická chemie

  • 2009 - 2012
    • •
  • 6 276 tis. Kč
    • •
  • 6 276 tis. Kč
    • •
  • GA ČR
Project

New cytostatic agents-problems of their cardiotoxicity and potential cardiopotective activity. (IZ4212)

Study of cardiotoxicity and potential cardioprotective effects of new cytostatic drugs (benzo/c/fluorens, Oracin) using approaches of quantal-chemistry, cardiovascular pharmacology, toxicology, biochemistry and morphology in animals in vivo ...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 1997 - 1999
    • •
  • 1 290 tis. Kč
    • •
  • 1 026 tis. Kč
    • •
  • MZ
Project

Chemical biology approach to study anthracycline cardiotoxicity and pharmacological cardioprotection with focus on topoisomerase II beta (GA21-16195S)

at the use of chemical biology for study of anthracycline cardiotoxity pathophysiology...

Pharmacology and pharmacy

  • 2021 - 2023
    • •
  • 10 035 tis. Kč
    • •
  • 10 035 tis. Kč
    • •
  • GA ČR
Project

Anthracycline-induced DNA damage signaling in the heart implications for cardiotoxicity development and its pharmacological modulations (GA23-06558S)

Cardiotoxicity and heart failure caused by anthracycline anticancer drugs (ANTs, e.g., doxorubicin or daunorubicin) have been recently linked to topoisomerase II beta (TOP2B)-induced DNA damage in the heart. However, the mechanistic role of ...

Pharmacology and pharmacy

  • 2023 - 2025
    • •
  • 9 981 tis. Kč
    • •
  • 9 810 tis. Kč
    • •
  • GA ČR
Project

Study of individual topoisomerase II isoforms in anticancer and cardiotoxic effects of anthracyclines and their modulations by bisdioxopiperazines (GA18-08169S)

Topoisomerase II (TOP2) alpha isoform is a well-established target of anticancer action of anthacycline antibiotics (e.g. daunorubicin, doxorubicin), whereas their cardiotoxicity has been traditionally attributed to intramyocardial free radi...

Pharmacology and pharmacy

  • 2018 - 2020
    • •
  • 9 622 tis. Kč
    • •
  • 9 622 tis. Kč
    • •
  • GA ČR
Project

Research on the development of cardiotoxicity following breast radiotherapy (TTSSUJB402)

of developing cardiotoxicity, which manifests long after radiation exposure (10 years and duration, it is expected that potential cardiotoxicity will already be observable to cardiotoxicity, which will be the project’s pri...

Oncology

  • 2025 - 2031
    • •
  • 20 325 tis. Kč
    • •
  • 20 325 tis. Kč
    • •
  • TA ČR
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