All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”
EN
ČeštinaEnglish

Filters

38 (0,146s) •

Project

Role of caspase-2 in apoptosis induction by taxanes in breast cancer cells (GA301/09/0362)

It seems that caspase-2 can play a major role in apoptosis induction in cancer on differing expression of caspase-2L and caspase-2S that are two isoforms of caspase-2 to elucidation of the role of caspase-...

EB - Genetika a molekulární biologie

  • 2009 - 2013
    • •
  • 7 109 tis. Kč
    • •
  • 7 077 tis. Kč
    • •
  • GA ČR
Project

Investigation of novel functions of caspases by their simultaneous quantification in individual cells (GA20-00726S)

functions of caspases in cell proliferation and differentiation at the single-cell level. While functions of caspases in apoptosis are well-known, the specific components of caspase cascades in the novel functions are not ...

Analytical chemistry

  • 2020 - 2022
    • •
  • 5 758 tis. Kč
    • •
  • 5 758 tis. Kč
    • •
  • GA ČR
Project

Specification of osteogenic potential of caspases in context of craniofacial development (GA19-14727S)

osteoblasts differentiate from mesenchymal precursors. Caspases are known to contribute of their functions. The latest data indicate the presence of active caspases in non-apoptotic of caspase activity in osteoblastic cell...

Developmental biology

  • 2019 - 2022
    • •
  • 8 009 tis. Kč
    • •
  • 7 742 tis. Kč
    • •
  • GA ČR
Project

Caspase-1 and chondrocytes integration of osteoarthritis oriented research (LUABA22019)

. Caspases are cysteine proteases well-known from apoptotic and inflammatory processes the effect of general caspase inhibition on expression of OA-related genes in healthy chondrocytes. However, the impact of individual cas...

Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])

  • 2022 - 2024
    • •
  • 1 190 tis. Kč
    • •
  • 1 190 tis. Kč
    • •
  • MŠMT
Project

Senescence and proteases – relevance to osteoarthritis and osteoporosis (LUC25127)

Specific aims of the Inter-COST project include: 1) Activation of caspases in senescent cells 2) Osteogenic markers after caspase inhibition in senescent cells with focus on clinically important markers associated with OA and OP 3) ...

Other biological topics

  • 2025 - 2028
    • •
  • 3 741 tis. Kč
    • •
  • 3 741 tis. Kč
    • •
  • MŠMT
Project

Caspases as novel regulators in osteogenic cellular networks (LTC18081)

The major aim of the project is to join a running COST action in order to integrate the proposed research team into the European Research Networks to facilitate and accelerate research in the area of novel functions of cysteine proteases in hard tiss...

Genetics and heredity (medical genetics to be 3)

  • 2018 - 2020
    • •
  • 3 961 tis. Kč
    • •
  • 3 413 tis. Kč
    • •
  • MŠMT
Project

Single cell analysis of signaling molecules (GA14-28254S)

of instrumentation for chemiluminescent quantification of caspases in various individual cells; (ii) Synthesis of sensors for localization of different caspases in cellular of caspases and their functions in cellular diffe...

CB - Analytická chemie, separace

  • 2014 - 2016
    • •
  • 6 758 tis. Kč
    • •
  • 6 758 tis. Kč
    • •
  • GA ČR
Project

Compensatory mechanisms and alternative signalling pathways in embryonal apoptosis (IAA600450904)

via membrane receptors or intrinsic pathways. Activation of caspase machinery be activated, moreover, compensatory mechanisms among caspases appear likely to be engaged, particularly caspase compensatory mechanisms will be...

ED - Fyziologie

  • 2009 - 2011
    • •
  • 2 970 tis. Kč
    • •
  • 2 970 tis. Kč
    • •
  • AV ČR
Project

Novel physiological functions of apoptotic pathway components in hard tissue cells (GA16-18430S)

, but recent results suggest also a role in cell differentiation. Caspases, as apoptosis, primarily FasL, caspase-8 and -3 in intramembranous bones. Temporospatial......

ED - Fyziologie

  • 2016 - 2018
    • •
  • 4 653 tis. Kč
    • •
  • 4 653 tis. Kč
    • •
  • GA ČR
Project

Mechanisms of cell death in the primary enamel knot (KJB500450802)

the following pathways. Cell death in PEK was shown as caspase dependent, nevertheless, alternative death (necrosis, autophagy) after caspase inhibition might be involved......

EA - Morfologické obory a cytologie

  • 2008 - 2010
    • •
  • 1 581 tis. Kč
    • •
  • 1 581 tis. Kč
    • •
  • AV ČR
  • 1 - 10 out of 38