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5 865 (0,131s) •

Project

Senescence and proteases – relevance to osteoarthritis and osteoporosis (LUC25127)

Specific aims of the Inter-COST project include: 1) Activation of caspases in senescent cells 2) Osteogenic markers after caspase inhibition in senescent cells with focus on clinically important markers associated ...

Other biological topics

  • 2025 - 2028
    • •
  • 3 741 tis. Kč
    • •
  • 3 741 tis. Kč
    • •
  • MŠMT
Project

Caspase-1 and chondrocytes integration of osteoarthritis oriented research (LUABA22019)

the effect of general caspase inhibition on expression of OA-related genes in healthy yet to be specified. Caspase-1 is a hot candidate regarding osteoarthritis of the caspase-1 inhibitory eff...

Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])

  • 2022 - 2024
    • •
  • 1 190 tis. Kč
    • •
  • 1 190 tis. Kč
    • •
  • MŠMT
Project

Specification of osteogenic potential of caspases in context of craniofacial development (GA19-14727S)

osteoblasts differentiate from mesenchymal precursors. Caspases are known to contribute of their functions. The latest data indicate the presence of active caspases in non-apoptotic cells of craniofacial bones in vivo. Additionally...

Developmental biology

  • 2019 - 2022
    • •
  • 8 009 tis. Kč
    • •
  • 7 742 tis. Kč
    • •
  • GA ČR
Project

Study of expression and activation of apoptogenic caspases and of levels of their inhibitors in non-small cell lung carcinoma (NC6610)

Study of expression and activation of apoptogennic caspases and of levels of their inhibitors XIAP and survivin in human non-small cell lung carcinoma with the aim to evaluate their correlation with progression of this cancer disease.......

FD - Onkologie a hematologie

  • 2001 - 2003
    • •
  • 3 500 tis. Kč
    • •
  • 3 470 tis. Kč
    • •
  • MZ
Project

Role of caspase-2 in apoptosis induction by taxanes in breast cancer cells (GA301/09/0362)

It seems that caspase-2 can play a major role in apoptosis induction in cancer on differing expression of caspase-2L and caspase-2S that are two isoforms of caspase-2 to elucidation of the role of caspase-...

EB - Genetika a molekulární biologie

  • 2009 - 2013
    • •
  • 7 109 tis. Kč
    • •
  • 7 077 tis. Kč
    • •
  • GA ČR
Project

Compensatory mechanisms and alternative signalling pathways in embryonal apoptosis (IAA600450904)

via membrane receptors or intrinsic pathways. Activation of caspase machinery follows as the next steps. In the case of apoptosis absence/inhibition in vivo be activated, moreover, compensatory mechanisms among caspases ap...

ED - Fyziologie

  • 2009 - 2011
    • •
  • 2 970 tis. Kč
    • •
  • 2 970 tis. Kč
    • •
  • AV ČR
Project

Mechanisms of programmed cell death completion in human tumor cells induction by iron deprivation (KJB5052401)

will assess (1) the activation of executioner caspases-6, -7, (2) the interactions of caspases with IAPs, (3) the release of Smac/Diablo and Omi/HtrA2 from mitochondria (Raji) B lymphomas. Cell death involved in Raji is no...

EB - Genetika a molekulární biologie

  • 2004 - 2005
    • •
  • 775 tis. Kč
    • •
  • 387 tis. Kč
    • •
  • AV ČR
Project

Mechanisms of cell death in the primary enamel knot (KJB500450802)

the following pathways. Cell death in PEK was shown as caspase dependent, nevertheless, alternative death (necrosis, autophagy) after caspase inhibition might be involved......

EA - Morfologické obory a cytologie

  • 2008 - 2010
    • •
  • 1 581 tis. Kč
    • •
  • 1 581 tis. Kč
    • •
  • AV ČR
Project

Role of S100A4 (metastasin) in the pathogenesis of rheumatoid arthritis (NR9082)

by stimulatory experiments with an additional inhibition of the RAGE and intracellular roles, XIAP, smac), pro-inflammatory cytokines (TNF, IL-1, IL-6 and MCP-1) and matrix degrading enzymes (MMP-1, MMP-3 and MMP-...

FP - Ostatní lékařské obory

  • 2006 - 2009
    • •
  • 5 693 tis. Kč
    • •
  • 5 284 tis. Kč
    • •
  • MZ
Project

Gene screening of actinomycetes producing new substances with potential therapeutic applications to modulate immune mechanisms. (IAA600660607)

The project aims to acquire new secondary metabolites of the manumycin type from soil-isolated actinomycetes. These non-steroidal compounds show interesting immunomodulatory features (IL-1ß convertase inhibition) that could potentially be us...

EE - Mikrobiologie, virologie

  • 2006 - 2008
    • •
  • 4 337 tis. Kč
    • •
  • 4 337 tis. Kč
    • •
  • AV ČR
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