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4 153 (0,142s) •

Project

Study of expression and activation of apoptogenic caspases and of levels of their inhibitors in non-small cell lung carcinoma (NC6610)

Study of expression and activation of apoptogennic caspases and of levels of their inhibitors XIAP and survivin in human non-small cell lung carcinoma with the aim to evaluate their correlation with progression of this cancer disease.......

FD - Onkologie a hematologie

  • 2001 - 2003
    • •
  • 3 500 tis. Kč
    • •
  • 3 470 tis. Kč
    • •
  • MZ
Project

Role of caspase-2 in apoptosis induction by taxanes in breast cancer cells (GA301/09/0362)

in apoptotic pathway(s),(3) expression of caspase-2L and caspase-2S in relation to taxaneIt seems that caspase-2 can play a major role in apoptosis induction in cancer on differing expression of caspase-2...

EB - Genetika a molekulární biologie

  • 2009 - 2013
    • •
  • 7 109 tis. Kč
    • •
  • 7 077 tis. Kč
    • •
  • GA ČR
Project

Mechanisms of programmed cell death completion in human tumor cells induction by iron deprivation (KJB5052401)

(Raji) B lymphomas. Cell death involved in Raji is not related to caspase-9, caspase-3 activation. The aim of this project is to describe the caspase-9, -3 will assess (1) the activation of executioner

EB - Genetika a molekulární biologie

  • 2004 - 2005
    • •
  • 775 tis. Kč
    • •
  • 387 tis. Kč
    • •
  • AV ČR
Project

Apoptotic and non-apoptotic functions of caspases in hard tissue formation (GAP502/12/1285)

is apparently caspase dependent, but the complete functional network has not been clarified yet. Ourresults in caspase-9 and caspase-3 deficient mice show importance caspases, particularly in cell differe...

ED - Fyziologie

  • 2012 - 2014
    • •
  • 3 747 tis. Kč
    • •
  • 3 747 tis. Kč
    • •
  • GA ČR
Project

14-3-3 protein dependent regulation of caspase-2 (GA17-00726S)

Caspase-2 (C2), a cysteine-dependent and aspartate-specific intracellular. Phosphorylated procaspase-2 (proC2) binds to the 14-3-3 protein and this interaction blocks mechanism we propose to: i) verify sites responsible for...

EB - Genetika a molekulární biologie

  • 2017 - 2019
    • •
  • 8 069 tis. Kč
    • •
  • 7 580 tis. Kč
    • •
  • GA ČR
Project

Sensitization of leukemic cells to radiation-induced apoptosis by the death ligand TRAIL (GP202/02/D023)

arereleased from mitochondria to cytosol and caspase 9 is activated. Caspase 9 then activates effector caspase 3. Second apoptotic pathway begins by activation of so called direct activation of caspase 8,...

BF - Elementární částice a fyzika vysokých energií

  • 2002 - 2005
    • •
  • 435 tis. Kč
    • •
  • 435 tis. Kč
    • •
  • GA ČR
Project

Senescence and proteases – relevance to osteoarthritis and osteoporosis (LUC25127)

Specific aims of the Inter-COST project include: 1) Activation of caspases in senescent cells 2) Osteogenic markers after caspase inhibition in senescent cells with focus on clinically important markers associated with OA and OP

Other biological topics

  • 2025 - 2028
    • •
  • 3 741 tis. Kč
    • •
  • 3 741 tis. Kč
    • •
  • MŠMT
Project

Investigation of novel functions of caspases by their simultaneous quantification in individual cells (GA20-00726S)

functions of caspases in cell proliferation and differentiation at the single-cell level. While functions of caspases in apoptosis are well-known, the specific components of caspase cascades in the novel functions are not ...

Analytical chemistry

  • 2020 - 2022
    • •
  • 5 758 tis. Kč
    • •
  • 5 758 tis. Kč
    • •
  • GA ČR
Project

Novel physiological functions of apoptotic pathway components in hard tissue cells (GA16-18430S)

, primarily FasL, caspase-8 and -3 in intramembranous bones. Temporospatial, but recent results suggest also a role in cell differentiation. Caspases, as apoptosis......

ED - Fyziologie

  • 2016 - 2018
    • •
  • 4 653 tis. Kč
    • •
  • 4 653 tis. Kč
    • •
  • GA ČR
Project

Specification of osteogenic potential of caspases in context of craniofacial development (GA19-14727S)

osteoblasts differentiate from mesenchymal precursors. Caspases are known to contribute of their functions. The latest data indicate the presence of active caspases in non-apoptotic of caspase activity in osteoblastic cell...

Developmental biology

  • 2019 - 2022
    • •
  • 8 009 tis. Kč
    • •
  • 7 742 tis. Kč
    • •
  • GA ČR
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