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6 260 (0,203s) •

Project

T cell receptor signaling and fate decisions made by peripheral T cells in homeostasis and during inflammation (GJ16-09208Y)

Proper T cell fate choices are required for efficient immune responses as well as for maintaining self-tolerance. Incorrect T cell fate decisions may trigger allergy, autoimmunity, or immunodeficiency. T <...

EC - Imunologie

  • 2016 - 2018
    • •
  • 9 315 tis. Kč
    • •
  • 7 968 tis. Kč
    • •
  • GA ČR
Project

Fate decisions in the dental placode an investigation into the signalling factors that determine cell fate decisions in the early oral cavity (GA18-04859S)

Understanding cell fate decisions is an essential goal in developmental biology of disease. In this proposal we aim to investigate the decisions that determine fate of cells during development of ...

Developmental biology

  • 2018 - 2020
    • •
  • 8 687 tis. Kč
    • •
  • 8 198 tis. Kč
    • •
  • GA ČR
Project

Elucidation of Haspin kinase interactome and its role in the context of cell plasticity (GA23-06472S)

Cell cycle progression is closely linked to self-renewal, plasticity and cell fate decision making, allowing tissue specification, regeneration, and homeostasis, but significantly understudied role in regulation of...

Cell biology

  • 2023 - 2025
    • •
  • 8 615 tis. Kč
    • •
  • 8 615 tis. Kč
    • •
  • GA ČR
Project

Deciphering pancreas development and function at the single-cell level (GA25-15876S)

Understanding the embryonic development of the pancreas, particularly cell fate decisions, endocrine cell differentiation, and functional maturation of endocrine cells fates. At the single cel...

Developmental biology

  • 2025 - 2027
    • •
  • 11 748 tis. Kč
    • •
  • 11 748 tis. Kč
    • •
  • GA ČR
Project

Functional characterisation of identified novel candidate cell-fate influencing genes during pre-implantation mouse development (GA13-03295S)

to be important. Here we propose to functionally verify and characterise the cell-fate cell-fate choice. Such fundamental research will appeal to academic and clinicalMammalian blastocyst embryos have three segreg...

EB - Genetika a molekulární biologie

  • 2013 - 2016
    • •
  • 6 889 tis. Kč
    • •
  • 6 889 tis. Kč
    • •
  • GA ČR
Project

Cellular responses to replication stress Mechanisms and the role of fragile sites in genomic instability (IAA501370902)

and cell fate decisions, focusing on DNA damage response to irreparable DNA breakage replicationstress in cancer cells and combine chemical and genetic tools to modulate the fate decisions in can...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 3 242 tis. Kč
    • •
  • 3 242 tis. Kč
    • •
  • AV ČR
Project

Molecular mechanisms underlying cell-fate decisions in the intestine (GA14-33952S)

of the project is to uncover the mechanisms underlying cell-fate decisions in the intestine on actively cycling crypt base columnar stem cells (CBCs) that reside at the bottom part of microscopic invaginations cal...

EB - Genetika a molekulární biologie

  • 2014 - 2018
    • •
  • 7 470 tis. Kč
    • •
  • 7 470 tis. Kč
    • •
  • GA ČR
Project

Crosstalk between nuclear receptor and Wnt signaling in C. elegans (GA204/07/0948)

interplay between a conserved nuclear receptor NHR-25 and a Wnt pathway during cell fate decision in vivo. Our model is the C. elegans somatic gonad stem cell, whose single asymmetric division establishes the plan...

EB - Genetika a molekulární biologie

  • 2007 - 2011
    • •
  • 3 802 tis. Kč
    • •
  • 3 802 tis. Kč
    • •
  • GA ČR
Project

Mechanisms behind the genotoxic response upon exposure to organic compounds from gasoline and alternative fuel emissions in human lung cells (GJ18-06548Y)

their involvement in cell fate decision. This study may bring a new findings concerning and their blends with bioaditives (ethanol and butanol) in humanl lung cells (BEAS-2B). We response (DDR), key factors determ...

Biochemistry and molecular biology

  • 2018 - 2022
    • •
  • 4 074 tis. Kč
    • •
  • 4 074 tis. Kč
    • •
  • GA ČR
Project

Role of Mmi1 in redistribution of Cdc14 phosphataseand stress-induced fragmentation of mitochondria (7AMB16AT006)

understanding general aspects of a TCTP function in and stress survival and cell fate or death” decision. Yeast protein Mmi1 is a homolog of the mammalian "translationally controlled tumor protein" (TCTP), which plays a cr...

EB - Genetika a molekulární biologie

  • 2016 - 2017
    • •
  • 152 tis. Kč
    • •
  • 152 tis. Kč
    • •
  • MŠMT
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