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6 453 (0,142s) •

Project

Polychlorinated persistent organic pollutants in the etiopathogenesis of obesity and insulin resistance (NT14330)

The aim of study is in experiment in vitro, on cell lines of adipocytes (multipotent adipose-derived stem cells, preadipocytes adipocytes) to observe effects lines to evaluate proliferation and differentiation of <...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2013 - 2015
    • •
  • 4 325 tis. Kč
    • •
  • 4 325 tis. Kč
    • •
  • MZ
Project

Mechanism(s) controlling sensitivity and/or resistance of cancer cell lines to anticancer analogues of vitamin E (GP204/09/P632)

cancer cell lines with acquired resistance to anticancer derivatives of vitamin E to cancercell lines than to normal cell lines and also exhibits antiangiogenic activity in selected endothelial cell

CE - Biochemie

  • 2009 - 2010
    • •
  • 624 tis. Kč
    • •
  • 624 tis. Kč
    • •
  • GA ČR
Project

Rearangement of chromosomes of heteronuclear cell line derived from the human uveal melanoma and their share in permanent growth in vitro. (NC6148)

Rearangement of chromosomes and their share in permanent growth of malignant melanoma cell line in vitro....

FD - Onkologie a hematologie

  • 2000 - 2001
    • •
  • 2 369 tis. Kč
    • •
  • 2 369 tis. Kč
    • •
  • MZ
Project

Analysis of PTEN gene interactions in prostate cancer cell lines (NC6779)

in the prostate cancer cell lines LNCaP, DU-145, PC-3 2) the analysis PTEN´s interactions with the selected proteins regulating cell cycle and with the nucler receptors influencing the transcription in hormonal dependent a...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 904 tis. Kč
    • •
  • 875 tis. Kč
    • •
  • MZ
Project

Impact of the digestion and absorption processes on the final biological activity of diet phytonutrients real health added-value (8X20023)

, papaverine, berberine and others) on human model cell lines (ovarian granulosa cell line HGL5, ovarian carcinoma line, etc.). 3. In vitro testing of selected phytonutrients+ (CD1c+) dendritic cells

Cell biology

  • 2020 - 2022
    • •
  • 203 tis. Kč
    • •
  • 203 tis. Kč
    • •
  • MŠMT
Project

Cell cycle regulation in human embryonic stem cells - study toward establishing identifiable characteristics of high quality cells (GA301/05/0463)

risk. Differences among hES cell lines and/or cultures in effectiveness cell linesMany aspects of the biology of human embryonic stem (hES) cells must be understood before any therapeutical application of...

EI - Biotechnologie a bionika

  • 2005 - 2007
    • •
  • 2 918 tis. Kč
    • •
  • 2 918 tis. Kč
    • •
  • GA ČR
Project

Identification of new prognostic markers and therapeutic target molecules in soft tissue sarcoma (GA17-17636S)

cells, exploitations of cell line progression series) to identify new progression with defining transcriptomes in two well characterized sarcoma cell line progression series, based both on progression sta...

FD - Onkologie a hematologie

  • 2017 - 2021
    • •
  • 8 858 tis. Kč
    • •
  • 8 858 tis. Kč
    • •
  • GA ČR
Project

Single-cell transcriptomics for the analysis of subclonal heterogeneity and clonal evolution of mantle cell lymphoma (GA23-05377S)

established lymphoma cell lines and PDXs derived from one patient. New insights on subclonal heterogeneity and relevance of lymphoma cell lines and PDX models in directMantle cell lymphoma (MCL) is a chro...

Hematology

  • 2023 - 2025
    • •
  • 15 740 tis. Kč
    • •
  • 15 716 tis. Kč
    • •
  • GA ČR
Project

Influence of transport and metabolism of used and novel taxanes on effects and their mechanisms in patients and tumor cell lines (NR9426)

metabolites and determining their efficiency in breast cancer cell lines. To assess transport of novel taxanes in breast cancer cell lines as in contrast to presently used paclitaxel, docetaxel and doxorubicin, th...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 5 722 tis. Kč
    • •
  • 5 226 tis. Kč
    • •
  • MZ
Project

Targeted gene silencing using siRNAs in primary cell cultures of CML patients and leukemic cell lines (K562, MOLM-7, KU-812) (NR7989)

In the project siRNAs will be used for gene expression silencing of the genes MMP8,MMP9,PCNA,MAPK p38,Bmi-1,BCR/ABL in CML-derived leukemic cell lines and in primary cultures obtained with cultivation of peripheral blood leukocytes ...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 3 699 tis. Kč
    • •
  • 3 291 tis. Kč
    • •
  • MZ
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