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Cell volume regulation in glial cells during brain ischemia/reperfusion (GAP303/10/1338)
participating in astrocyte and NG2 glia swelling and volume regulation during ischemia cells to regulate their volume, changes in cell membrane properties duri...
FH - Neurologie, neurochirurgie, neurovědy
- 2010 - 2012 •
- 3 996 tis. Kč •
- 3 996 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2010 - 31. 12. 2012
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Gene expression profiling and functional characterization of glial cell subpopulations following ischemic brain injury (GA13-02154S)
and following cerebral ischemia using transgenic mice in which different astrocyte/NG2-gliaAstrocytes and NG2-glia subpopulations display striking physiological high throughput platform ...
EB - Genetika a molekulární biologie
- 2013 - 2016 •
- 10 720 tis. Kč •
- 10 720 tis. Kč •
- GA ČR
Řešení projektu: 1. 2. 2013 - 31. 12. 2016
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Principal signaling pathways regulating NG2 glia proliferation and differentiation following brain injuries (GA17-04034S)
In the adult brain NG2-glia represent an important cell type in relation an important role in proliferation and cell-fate decision of NG2-glia. The main objective of this study is to define the ro...
FH - Neurologie, neurochirurgie, neurovědy
- 2017 - 2019 •
- 12 507 tis. Kč •
- 11 937 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2017 - 31. 12. 2019
Uznané náklady
Podpora ze státního rozpočtu (95%)
Poskytovatel: Grantová agentura České republiky
Disturbed regulation of mTOR signaling in glial cells following cerebral ischemia (GA23-06269S)
to the brain leads to pathological changes in glial cells. Thus, we aim to elucidate processes regulated by mTORC1/2 in glia following focal cerebral ischemia. First, we will characterize the expression of mTOR si...
Neurosciences (including psychophysiology)
- 2023 - 2025 •
- 9 885 tis. Kč •
- 9 885 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2023 - 31. 12. 2025
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
The Role of TRPV4 Channels in the Development of Cytotoxic Edema and Formation of Glial Scar Following Ischemic Brain Injury (GJ18-06446Y)
with cell-specific Cre-reporter mice, we also aim to study the differentiation of NG2 glia into oligodendrocytes after ischemia, and cell death/proliferation induced or specific chemical compounds. TRPV4 ...
Neurosciences (including psychophysiology)
- 2018 - 2018 •
- 602 tis. Kč •
- 602 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2018 - 31. 12. 2018
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Induction of neuro- and gliogenesis in rat brain after ischemia - the role of morphogenes and growth factors in the nervous tissue regeneration. (GA305/09/0717)
. In addition to endogenous neural stem cells, also astrocytes and NG2-glia play as the proliferation and migration of astrocytes and NG2-glia. This study should also contribute of stem <...
ED - Fyziologie
- 2009 - 2011 •
- 3 381 tis. Kč •
- 3 381 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2009 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
The role of glial TRPV4 channels in brain edema formation and post-ischemic regeneration (GA20-05770S)
, such as synaptic transmission regulation, astrocytic intercommunication or sensing of noxious and represent a promising target for new therapies. Besides their role in cell volume regulation TRPV4 expres...
Neurosciences (including psychophysiology)
- 2020 - 2023 •
- 10 671 tis. Kč •
- 10 671 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2020 - 30. 6. 2023
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Involvement of Wnt/β-catenin signaling in neurogenesis and gliogenesis following brain ischemic injury - analysis at the single cell level (GA21-24674S)
indicate that the Wnt signaling pathway promotes cell proliferation and neurogenesis in the brain tissue after brain injury. The project is focused on two cell populations of glial cells, i.e. NG2 glia an...
Neurosciences (including psychophysiology)
- 2021 - 2023 •
- 12 173 tis. Kč •
- 12 173 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2021 - 31. 12. 2023
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
The role of glial cells during ischemia/reperfusion and in the course of nervous tissue regeneration. (GA305/06/1316)
glutamate and purinergic receptors, in astrocytes, microglia and NG2 proteoglycanIschemia/reperfusion induces dramatic changes in intracellular Ca2+ concentration ([Ca2+]i) in both neurons and glial cells. These c...
FH - Neurologie, neurochirurgie, neurovědy
- 2006 - 2008 •
- 3 148 tis. Kč •
- 3 148 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2006 - 31. 12. 2008
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Glial cells- the key players in the progression of amyotrophic lateral sclerosis (GA19-02046S)
A striking functional heterogeneity exists within astrocytes, NG2-glia and function of glial cells in the progression of amyotrophic lateral sclerosis (ALS) using transgenic mice carrying superoxide dismutase mutat...
Neurosciences (including psychophysiology)
- 2019 - 2023 •
- 9 950 tis. Kč •
- 9 734 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2019 - 31. 12. 2023
Uznané náklady
Podpora ze státního rozpočtu (98%)
Poskytovatel: Grantová agentura České republiky
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