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1 131 (0,245s) •

Project

The role of the JAK/STAT signalling pathway in cellular senescence (GA204/08/1418)

Cellular senescence is proposed to be a tumorigenesis barrier to slow or inhibit the progression of proneoplastic lesions to neoplasia. In our recent work we found persistent activation of JAK/STAT signaling pathway during drug-indu...

CE - Biochemie

  • 2008 - 2012
    • •
  • 6 643 tis. Kč
    • •
  • 6 643 tis. Kč
    • •
  • GA ČR
Project

Post-translational modifications of Daxx and their functional relevance in DNA damage response and cellular senescence (GPP305/11/P683)

Cellular senescence and cell death mechanisms are commonly disrupted in cancer, cellular senescence has been observed to be associated with activation of DNA damage, exploring the role of Daxx in DNA damage respons...

EB - Genetika a molekulární biologie

  • 2011 - 2014
    • •
  • 2 199 tis. Kč
    • •
  • 2 199 tis. Kč
    • •
  • GA ČR
Project

Development of brain organoid models to study the role of cellular senescence in the pathogenesis of glioblastoma (GA24-11357S)

therapies. Recent advances in GB research identifying cellular senescence of cellular senescence in GB is needed to fulfill this goal. In this proposal, we want cellular senescence, the compositi...

Oncology

  • 2024 - 2026
    • •
  • 12 422 tis. Kč
    • •
  • 11 822 tis. Kč
    • •
  • GA ČR
Project

Inhibition of JAK/STAT3 signalling pathway in cancer therapy (GA18-14259S)

of cellular senescence, thus its inhibition is a promising way to control cancer progression and to suppress adverse effects of senescent cells on tissue microenvironment able to inhibit a tumor growth and development of <...

Medicinal chemistry

  • 2018 - 2022
    • •
  • 11 770 tis. Kč
    • •
  • 11 355 tis. Kč
    • •
  • GA ČR
Project

Role of oxidative stress in the interplay between cellular senescence and apoptosis (GA15-03379S)

Primarily, cellular senescence (CS) comprises a barrier to cell transformation, however, a persistence of senescent cells in tissues is thought to contribute-related pathologies. A source of these perturbing effects is ...

FD - Onkologie a hematologie

  • 2015 - 2019
    • •
  • 8 831 tis. Kč
    • •
  • 8 831 tis. Kč
    • •
  • GA ČR
Project

Premature cellular senescence Mechanisms and links with cancer (GA13-17555S)

Cellular senescence is a physiological response of the cells to hyperactivated withholding cells in permanent cell cycle arrest. Senescence plays important role senescence may promote organism ageing and age-relate...

EB - Genetika a molekulární biologie

  • 2013 - 2016
    • •
  • 13 036 tis. Kč
    • •
  • 13 036 tis. Kč
    • •
  • GA ČR
Project

The role of PML in cellular senescence (IAA500390501)

PML bodies are large dynamic nuclear complexes implicated in regulation of cellular senescence, however, their function is still unclear. This project has three for understanding cellular senescence and response to...

EA - Morfologické obory a cytologie

  • 2005 - 2009
    • •
  • 3 474 tis. Kč
    • •
  • 3 474 tis. Kč
    • •
  • AV ČR
Project

Parental senescence effects and their mechanisms in a short-lived vertebrate (GA22-21198S)

phenotype and cellular markers. We will then test parental senescence effectsSenescence is one of the most studied phenomena of living organisms. We only begin to embrace senescence in its multiple dimensions and ...

Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

  • 2022 - 2024
    • •
  • 8 855 tis. Kč
    • •
  • 8 615 tis. Kč
    • •
  • GA ČR
Project

Ribosomal stress, ribosomal DNA stability and cellular senescence role of PML (GA19-21325S)

and cellular senescence and the role of PML in these processes. The specific aims include investigation of changes of rDNA copy number during ribosomal stress and cellular senescence consuming more than 60% of

Human genetics

  • 2019 - 2023
    • •
  • 10 468 tis. Kč
    • •
  • 9 864 tis. Kč
    • •
  • GA ČR
Project

Specific elimination of senescent cells using mitochondria-targeted compounds (GA18-02550S)

proposed that irreversibly arrested senescent cells exacerbate the progression of selective elimination of senescent cells after inhibition of the mitochondrial function of senescent cells elimination on progression of dia...

Cell biology

  • 2018 - 2020
    • •
  • 7 169 tis. Kč
    • •
  • 7 169 tis. Kč
    • •
  • GA ČR
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