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2 965 (0,156s) •

Project

The role of the JAK/STAT signalling pathway in cellular senescence (GA204/08/1418)

Cellular senescence is proposed to be a tumorigenesis barrier to slow or inhibit the progression of proneoplastic lesions to neoplasia. In our recent work we found persistent activation of JAK/STAT signaling pathway during drug-indu...

CE - Biochemie

  • 2008 - 2012
    • •
  • 6 643 tis. Kč
    • •
  • 6 643 tis. Kč
    • •
  • GA ČR
Project

Molecular basis of FGFR3 signal transduction in skeletal dysplasia (GAP305/11/0752)

in cartilage. Among the least characterized areas of FGFR3 signaling lies the nature of protein complexes participating in transduction of the FGFR3 signal into the nucleus. This proposal aims on characterization of novel proteins ...

EB - Genetika a molekulární biologie

  • 2011 - 2013
    • •
  • 4 280 tis. Kč
    • •
  • 4 280 tis. Kč
    • •
  • GA ČR
Project

Notch signalling at the context of cellular metabolism. (GAP305/11/0126)

. Is there a link between cellular metabolic status and the outcome of Notch signaling activation assays to determine how Notch signaling is influenced by changes the cellular metabolic profile,creating an autoregu...

EB - Genetika a molekulární biologie

  • 2011 - 2013
    • •
  • 3 930 tis. Kč
    • •
  • 3 930 tis. Kč
    • •
  • GA ČR
Project

Complex approach to study on signals transfer in living organisms (IPP2052002)

and the responsesof cells,tissues and whole organisms to these signals. The object of the proposed project is to provide instrumentation which would enable us to study the signals, their transfer and responses to the signals

EB - Genetika a molekulární biologie

  • 2000 - 2001
    • •
  • 12 879 tis. Kč
    • •
  • 9 828 tis. Kč
    • •
  • AV ČR
Project

Flotillin a novel player in plant stress signalling (GA14-09685S)

attack by mobilizing signalling networks that allow them to overcome adverse situations. Little is known, however, about the cellular and molecular mechanisms signalling protein that specifically associates with eukaryotic...

CE - Biochemie

  • 2014 - 2018
    • •
  • 8 874 tis. Kč
    • •
  • 8 874 tis. Kč
    • •
  • GA ČR
Project

Cellular role of MAP kinase signaling cascade in plants through regulation of nucleation and organization of microtubular cytoskeleton. (7AMB13AT013)

Cell respond to external and internal cues by activation of cellular signalling and phosphatases. This project aims to find the link between cell signalling via mitogen and provides experience in cell signalling. P...

EB - Genetika a molekulární biologie

  • 2013 - 2014
    • •
  • 163 tis. Kč
    • •
  • 163 tis. Kč
    • •
  • MŠMT
Project

Single cell analysis of signaling molecules (GA14-28254S)

methods open up new possibilities for research in cellular biology and medical of signaling pathways. The research includes three basic areas: (i) Development; (ii) Synthesis of sensors for localization of different caspases in

CB - Analytická chemie, separace

  • 2014 - 2016
    • •
  • 6 758 tis. Kč
    • •
  • 6 758 tis. Kč
    • •
  • GA ČR
Project

Nonspecific phospholipase C Molecular, cellular and functional characterisation of novel plant enzyme (GAP501/12/1942)

Phospholipid signalling is one of the key cellular regulatory mechanisms in plants. Central role in this signalling play phospholipases. Molecular, cellular and functional characterization of the small gene family ...

ED - Fyziologie

  • 2012 - 2017
    • •
  • 11 317 tis. Kč
    • •
  • 11 317 tis. Kč
    • •
  • GA ČR
Project

Role of receptor/G protein preassembly in G protein signaling (GJ20-09628Y)

G proteins and G protein-coupled receptors (GPCRs) play a key role in cellular signal transduction. An important aspect of G protein signaling, the role of which the recently discovered “second wave” of GPCR signaling

Biophysics

  • 2020 - 2022
    • •
  • 4 908 tis. Kč
    • •
  • 4 875 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms of adverse and protective effects of morphine and methadone on the rat heart (IAA501110901)

doses of morphine and/or methadone on opioid and adrenergic signaling in the rat cardioprotective or adverse effects of these drugs. We shall analyze the cellular compartmentalization of myocardial G-protein-regulated signaling...

ED - Fyziologie

  • 2009 - 2013
    • •
  • 7 683 tis. Kč
    • •
  • 7 683 tis. Kč
    • •
  • AV ČR
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