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Synthesis and structure-activity relationships of skin ceramides and agents targeting them (GAP207/11/0365)
This interdisciplinary project aims at studying ceramides, i.e. the essential several series of skin ceramide analogs and evaluate the effects of the structural also aim at studying the behavior of ceramide analogs after to...
FR - Farmakologie a lékárnická chemie
- 2011 - 2013 •
- 2 034 tis. Kč •
- 2 034 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2011 - 31. 12. 2013
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Ceramide analogues as transdermal permeation enhancers (GP203/04/P042)
on ceramide-like enhancers. Synthetic ceramide analogues proved to be a valuable tool in an investigation of compound 14S24, a ceramide analogue able to repair disturbed skin barrier......
FR - Farmakologie a lékárnická chemie
- 2004 - 2006 •
- 605 tis. Kč •
- 605 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2004 - 1. 1. 2006
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Pre-clinical development of an acylceramide nanostructured delivery system to rescue the skin barrier in patients with ichthyosis (TH78020002)
This project aims at developing a nanostructured system containing human ultralong ceramides and their analogs for delivering these lipids into specific skin sites of patients with ichthyoses. Our approach is unique in specifically targeting...
Pharmacology and pharmacy
- 2022 - 2025 •
- 5 068 tis. Kč •
- 4 309 tis. Kč •
- TA ČR
Řešení projektu: 1. 3. 2022 - 30. 9. 2025
Uznané náklady
Podpora ze státního rozpočtu (85%)
Poskytovatel: Technologická agentura ČR
Ultralong chain ceramides in membrane models of healthy and diseased skin barrier (GC19-09135J)
In this joint Czech-German project, we propose to investigate the role of ultralong ceramides (both free and in the corneocyte lipid envelope) and long-periodicity lamellar phases in the skin barrier, which are essential components for life ...
Biophysics
- 2019 - 2021 •
- 7 012 tis. Kč •
- 6 957 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2019 - 31. 12. 2021
Uznané náklady
Podpora ze státního rozpočtu (99%)
Poskytovatel: Grantová agentura České republiky
Understanding the mechanisms of epidermal lipid barrier formation, damage and repair implications for skin diseases (GA25-17203S)
The main protective barrier of our body, necessary for terrestrial survival, is primarily located in the intercellular matrix of the uppermost skin layer. The molecular mechanisms of the formation of this hydrophobic, ceramide-rich lipid mix...
Pharmacology and pharmacy
- 2025 - 2027 •
- 11 956 tis. Kč •
- 11 704 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2025 - 31. 12. 2027
Uznané náklady
Podpora ze státního rozpočtu (98%)
Poskytovatel: Grantová agentura České republiky
Modification of membrane structures in relation to drug administration (GP202/07/P391)
The presented project introduces studies of membrane structures on a molecular level into pharmaceutical technology. This method is useful for elucidation of the interactions between drugs and/or pharmaceutical excipients with real mammalian membrane...
FR - Farmakologie a lékárnická chemie
- 2007 - 2009 •
- 781 tis. Kč •
- 781 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2007 - 31. 12. 2009
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Lipid membrane models – a new tool for studying pathophysiology of skin diseases at a molecular level (GA13-23891S)
delivered (pseudo)ceramides using lipid nanocarriers. This project will be the first...
FR - Farmakologie a lékárnická chemie
- 2013 - 2017 •
- 9 734 tis. Kč •
- 9 734 tis. Kč •
- GA ČR
Řešení projektu: 1. 2. 2013 - 31. 12. 2017
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Interdependencies between Inflammatory Processes and Barrier Lipids in Diseased Skin (GC16-25687J)
The objective of this Czech-German project is a more fundamental understanding of the physiological processes leading to a competent skin barrier and disturbances of these processes in atopic dermatitis. Through a collaboration of research teams expe...
FR - Farmakologie a lékárnická chemie
- 2016 - 2018 •
- 7 313 tis. Kč •
- 7 313 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2016 - 31. 12. 2018
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Corneocyte lipid envelope lipid-protein binding mechanisms and barrier rescue in ichthyosis models (GA24-10736S)
Disturbed formation of corneocyte lipid envelope (CLE) was described in severe skin diseases like ichthyoses; however, CLE function and mechanism of its formation have not been fully explained yet. In this project, oxidized human acylceramides will b...
Biophysics
- 2024 - 2026 •
- 8 301 tis. Kč •
- 8 301 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2024 - 31. 12. 2026
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Novel Insights into the Nanostructure of the Skin Lipid Barrier by Biophysical Methods (GF22-20839K)
The skin lipid barrier, an extracellular ceramide-based multilamellar lipid structure, is vital for our survival on dry land. This project addresses the unknown mechanisms and conditions of lipid assembly into a functional barrier and the ex...
Biophysics
- 2022 - 2025 •
- 7 911 tis. Kč •
- 7 911 tis. Kč •
- GA ČR
Řešení projektu: 1. 7. 2022 - 31. 12. 2025
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
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