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875 (0,139s) •

Project

Diagnosis of Alzheimer disease based on detections of complexes of amyloid beta peptide and of some endogenous substances in cerebrospinal fluid (NT11225)

After developments of new highly sensitive methods (via ELISA and surface plasmon resonance biosensors) , we will evaluate the levels of two complexes of amyloid beta peptides with either mitochondrial enzyme 17beta-hydroxysteroid dehydrogenase type ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2010 - 2013
    • •
  • 9 657 tis. Kč
    • •
  • 9 657 tis. Kč
    • •
  • MZ
Project

Endoscopic model of pressure ralations in the cranial cerebrospinal fluid space (NR7805)

The aim of the project is to create a descriptive mathematical and physical model of pressure relation in the cranial cerebrospinal fluid space in various types of obstructive hydrocephalus.......

FP - Ostatní lékařské obory

  • 2004 - 2005
    • •
  • 1 349 tis. Kč
    • •
  • 1 349 tis. Kč
    • •
  • MZ
Project

The role of neurosteroids in the etiopathogenesis of multiple sclerosis (NT13814)

In serum and cerebrospinal fluid of 60 patients with MS (40 women in the both phases of the menstrual cycle and 20 men) the steroid metabolom will be investigated. Levels of steroid hormones in serum and cerebrospinal f...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2012 - 2015
    • •
  • 4 302 tis. Kč
    • •
  • 4 302 tis. Kč
    • •
  • MZ
Project

Usage of cerebrospinal fluid microRNAs in diagnosis of brain tumors (NV15-34553A)

also in cerebrospinal fluid (CSF). From this perspective, analysis of CSF miRNAs...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 5 924 tis. Kč
    • •
  • 5 924 tis. Kč
    • •
  • MZ
Project

Sensitive method for early diagnosis and monitoring of central nervous system lymphoma using oncogenic miRNA in the cerebrospinal fluid and plasma (NV16-31586A)

fluids including cerebrospinal fluid (CSF). Proposed aim is to develop a method...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 10 493 tis. Kč
    • •
  • 9 841 tis. Kč
    • •
  • MZ
Project

Hormonal predictors for development of mental disorders in patients with hydrocephalus (NT12349)

Selected hormonal and other biochemical parameters in cerebrospinal fluid and serum, along with clinical status will be followed in patients with hydrocephalus treated neurosurgically by sucking off and subsequent channelling an exc...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2011 - 2014
    • •
  • 5 671 tis. Kč
    • •
  • 5 671 tis. Kč
    • •
  • MZ
Project

Use of neurocytoskeletal proteins and antibodies against them for diagnosis of Alzheimer´s disease (NS10369)

Neurocytoskeletal proteins (tau and phosphotau proteins, light and heavy subunits of neurofilaments) and antibodies against them will be measured using ELISA in samples of cerebrospinal fluid and serum in patients with and without A...

FH - Neurologie, neurochirurgie, neurovědy

  • 2009 - 2011
    • •
  • 4 773 tis. Kč
    • •
  • 4 773 tis. Kč
    • •
  • MZ
Project

The relationship between amyotrophic lateral sclerosis and the degree of cognitive impairment, markers of neurodegeneration and brain atrophy. A prospective study. (NR8491)

The aim of the study is to establish correlations between the the form of ALS (bulbar or limb onset), cognitive impairment and markers of neurodegeneration. The study is based on a complex initial evaluation of ALS patients (neuropsychological tests,...

FH - Neurologie, neurochirurgie, neurovědy

  • 2005 - 2008
    • •
  • 3 244 tis. Kč
    • •
  • 3 158 tis. Kč
    • •
  • MZ
Project

Investigation of cerebrospinal fluid in diagnostics of inborn errors of neurotransmitter metabolism and mitochondrial diseases. (NS10561)

The paediatric neurotransmitter disorders represent an enlarging group of neurological syndromes characterised by abnormalities of neurotransmitter synthesis and breakdown. The diagnosis of monogenic defects of neurotransmission is almost exclusively...

FG - Pediatrie

  • 2009 - 2011
    • •
  • 4 599 tis. Kč
    • •
  • 4 599 tis. Kč
    • •
  • MZ
Project

Free light chains of immunoglobulins in cerebrospinal fluid, serum and urine in multiple sclerosis (GP309/02/D066)

The goals of the project Free light chains of immunoglobulins in cerebrospinal fluid, serum and urine in multiple sclerosis are as follows: 1) to confirm the significance of the determination of free light chains of immunoglobulins ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2002 - 2005
    • •
  • 72 tis. Kč
    • •
  • 47 tis. Kč
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