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Projects

100 projects (0,125s)

Project

*Liquid fertilizer with complex and chelate bonded trace nutrients. (FT-TA3/076)

*The aim of the project is to find suitable complex and chelate compounds that facilitate uptake of micronutrients by plants. Only the compounds available on the market will be tested. Uptake of different forms of micronutrients (ionic salts...

CA - Anorganická chemie

  • 2006 - 2009
  • 13 800 tis. Kč
  • 8 798 tis. Kč
  • MPO
Project

Study of protective effects of novel iron chelators in the heart injury induced by oxidative stress and anthracycline cytostatics (GP305/05/P156)

prevention of these damages using novel iron chelators of the aroylhydrazone group-chelating efficacy. An in vitro model for the study of chelators at the level of cardiac chelators, an in vivo research will follo...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2007
  • 1 184 tis. Kč
  • 1 184 tis. Kč
  • GA ČR
Project

Anti-tumor effects of chelation therapy in myelodysplastic syndrome and identification of new therapeutic biomarkers. (NV16-31689A)

patients are typically transfusion dependent, and their chelation therapy not only to iron chelator in vitro. In vivo, 6-week applications of chelator to preleukemia+ cells from low-risk MDS patients receiving chelatio...

FD - Onkologie a hematologie

  • 2016 - 2020
  • 9 877 tis. Kč
  • 9 665 tis. Kč
  • MZ
Project

Effect of polyphenols and chelators on toxicity and effects of anthracyclines and taxanes (NL7567)

we will study effects of polyphenols and chelators on physical, chemical and biochemical interactions of doxorubin and its metabolites with Fe ions and enzymes in ROS effects of polyphenols and chelators on cardiotoxicity of doxorub...

FR - Farmakologie a lékárnická chemie

  • 2003 - 2005
  • 5 395 tis. Kč
  • 2 443 tis. Kč
  • MZ
Project

Efficient killing of cancer cells via mitochondrial targeting of iron chelators (GA18-13103S)

and iron chelation leads to apoptosis induction especially in cancers of hematopoietic origin, yet, the remaining problem is the specificity and toxicity of the chelators chelation. Our preliminary data show a strong enhan...

Biochemistry and molecular biology

  • 2018 - 2022
  • 7 144 tis. Kč
  • 7 144 tis. Kč
  • GA ČR
Project

Luminiscent lanthanide complexes in analytical and diagnostic applications. (OC D18.001)

The project is focused on development of lanthanide(III) chelates for diagnostics and therapy and the goals are summerised in the topics:i)Relationship between structure and activity of Ln(III) chelates relevant to Magnetic resonanc...

CA - Anorganická chemie

  • 2001 - 2004
  • 3 210 tis. Kč
  • 2 240 tis. Kč
  • MŠMT
Project

Chelation treatment of rats with incorporated radionuclides (GA307/97/1183)

new chelating agents that would be effective in mobilization of radiotoxic method for evaluation of efficacy of chelating agents in mobilization of polonium classes of chelators will be compared. The in vivo research into ...

FR - Farmakologie a lékárnická chemie

  • 1997 - 1999
  • 5 113 tis. Kč
  • 1 631 tis. Kč
  • GA ČR
Project

Chelation treatment of rats with incorporated radionuclides (IZ3991)

The research is focused on therapeutic removal of radionuclides after internal contamination of the body which represents a serious health problem. New chelating agents that would be more effective in mobilization of radiotoxic polonium and ...

FM - Hygiena

  • 1997 - 1999
  • 2 478 tis. Kč
  • 700 tis. Kč
  • MZ
Project

Hybrid supports from Polyhedral Oligomeric Silsesquiozane and chitin derivatives for membrane applications (GA203/02/1327)

The project is devoted to the study of macroporous chelating supports including with various chelating ligands will be carried out. New hybrid macroporous supports differing in morphology, type and concentration of the chelating...

CD - Makromolekulární chemie

  • 2002 - 2004
  • 2 961 tis. Kč
  • 1 182 tis. Kč
  • GA ČR
Project

Study of properties and the use of C,N- and Y,C,Y-chelated organometallic compounds (GA203/07/0468)

The project deals with the study of preparation, chemical and physical properties, structure and reactivity of C,N-chelated and N,C,N- a O,C,O-bischelated complexes of both transitionand main group metals with 2-(dimethylaminomethyl)phenyl-,...

CA - Anorganická chemie

  • 2007 - 2009
  • 2 305 tis. Kč
  • 2 305 tis. Kč
  • GA ČR
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