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5 (0,095s)

Project

Anti-inflammatory activity of Macleaya cordata extract and its component in vitro and in vivo (ME10071)

Aerial part of M. cordata is used in Chinese herbal medicine for the treatment of acute or chronic colitis. Quaternary benzofenathridine alkaloids sanguinarine and chelerythrine, the active principle of M. cordata, display a large number of ...

CE - Biochemie

  • 2010 - 2011
  • 992 tis. Kč
  • 642 tis. Kč
  • MŠMT
Project

Detoxification of quaternary isoquinoline alkaloids in vitro and in vivo, biological activity of their metabolites (GA525/07/0871)

will synthesize six possible metabolites of sanguinarine (SA) and chelerythrine (CHE), study...

GH - Výživa hospodářských zvířat

  • 2007 - 2010
  • 4 922 tis. Kč
  • 4 922 tis. Kč
  • GA ČR
Project

Benzophenanthridine alkaloids - study of their effects on cellular and molecular level (LH12176)

The aim of the project is to study benzophenanthridine alkaloids from the selected plant species in cooperation with chinese partner. The first aim is obtaining these alkaloids in sufficient amount. This assumes analysis of selected plant growing in ...

EB - Genetika a molekulární biologie

  • 2012 - 2015
  • 3 007 tis. Kč
  • 3 007 tis. Kč
  • MŠMT
Project

Plant sources of minor benzophenanthridine alkaloids and study of their interaction with DNA (GA525/08/0819)

Benzo[c]phenathridine alkaloids display many significant biological effects and are very intensively studied during past years. In addition to long time known sanguinarine and chelerythrine also the minor benzo[c]phenanhtidines sanguilutine,...

GC - Pěstování rostlin, osevní postupy

  • 2008 - 2010
  • 2 944 tis. Kč
  • 2 944 tis. Kč
  • GA ČR
Project

Changes of expression of pro-inflammatory enzymes caused by isoquinoline alkaloids during differentiation of promyelocytes into neutrophils (GP303/06/P193)

This project is designed to study possible mechanisms of anti-inflammatory effects and to detect side effects of sanguinarine, chelerythrine, berberine, protopine, and colchicine, all alkaloids displaying anti-inflammatory activity. The proj...

CE - Biochemie

  • 2006 - 2008
  • 1 044 tis. Kč
  • 1 044 tis. Kč
  • GA ČR
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