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Projects

10 projects (0,134s) •

Project

ReceptorX Integrated platform for drug discovery and development (TA02010212)

Within the ReceptorX project the technological and informatics platform for nuclear receptor profiling will be established. The project is based on the collaboration of experts in research areas of nuclear receptors and high-throughput screening (IMG...

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 26 037 tis. Kč
    • •
  • 15 373 tis. Kč
    • •
  • TA ČR
Project

Scientific-information Center of Chemical Informatics (LI200008)

Primary goal of the proposed project is an introduction of cheminformatics center covering wide range of chemical information. This center is aimed at both students and people from research and practice. Proposer jointly with a journal CHEMa...

AF - Dokumentace, knihovnictví, práce s informacemi

  • 2000 - 2002
    • •
  • 2 655 tis. Kč
    • •
  • 987 tis. Kč
    • •
  • MŠMT
Project

Identification of novel compounds for treatment of Friedreich ataxia (LTC18078)

The goal of the project is an identification of compounds that can correct aberrant phenotype of the cells derived from Friedreich ataxia patients and/or modify mitochondrial functions. We expect to identify novel structural motives/classes. The proj...

Pharmacology and pharmacy

  • 2018 - 2020
    • •
  • 1 995 tis. Kč
    • •
  • 1 995 tis. Kč
    • •
  • MŠMT
Project

Reshaping early-stage drug discovery by Artificial Intelligence (TP04020039)

Our novel award-winning AI-based software, deepHitMiner, enriches the top-scored compounds with real hits, thus fewer experiments are needed, and more candidate drugs have a chance to meet the requirements to enter the preclinical phase. This could l...

Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

  • 2022 - 2022
    • •
  • 2 145 tis. Kč
    • •
  • 1 000 tis. Kč
    • •
  • TA ČR
Project

Using Artificial Intelligence to Design New Bioactive Compounds in the Research of G Protein-Coupled Receptors (GN22-17367O)

G protein-coupled receptors (GPCRs) are a large protein family involved in complex signaling pathways in eukaryotes, some of which are implicated in a large number of diseases. GPCRs are activated by endogenous ligands which makes them interesting ta...

Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

  • 2022 - 2025
    • •
  • 4 855 tis. Kč
    • •
  • 4 855 tis. Kč
    • •
  • GA ČR
Project

MolMeDB - Validated Predictions of Small Molecule Interactions with Biological Membranes (GA17-21122S)

Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of molecules within the organism. A detailed knowledge of interactions between molecules and lipid membranes is ther...

EB - Genetika a molekulární biologie

  • 2017 - 2021
    • •
  • 4 971 tis. Kč
    • •
  • 4 554 tis. Kč
    • •
  • GA ČR
Project

Efficient chemical space exploration using multi-objective optimization (GP14-29032P)

Recently, we have developed a method for a systematic generation of the chemical space lying between a given pair of molecules. The intended use follows a similar property principle, i.e., if a pair of molecules shows a similar function molecules clo...

IN - Informatika

  • 2014 - 2016
    • •
  • 1 897 tis. Kč
    • •
  • 1 897 tis. Kč
    • •
  • GA ČR
Project

Targeting the Androgen Receptor Developing Binder Molecules for Prostate Cancer Therapy and Advancing NMR-AI Platform for Enhanced Drug Design. (TM05000031)

This project has 4 primary goals: 1. Integrate NexMR's 1D NMR screening technology for flexible proteins into AI|ffinity’s NMR-AI platform and adapt its AI algorithms to leverage it for improved predictive accuracy. 2. Capitalize on AnHorn's experti...

Biophysics

  • 2024 - 2025
    • •
  • 16 956 tis. Kč
    • •
  • 12 762 tis. Kč
    • •
  • TA ČR
Project

High-throughput screening for new anthelmintics (LTC19030)

Parasitic helminths infect about one-quarter of the world population. Parasites of livestock and crops cause significant economic loss. Most of the human and veterinary medicines belong to only a few classes from the point of view of the chemical str...

Microbiology

  • 2019 - 2021
    • •
  • 2 543 tis. Kč
    • •
  • 2 543 tis. Kč
    • •
  • MŠMT
Project

CZ-OPENSCREEN National infrastructure for chemical biology (LO1220)

, cheminformatics, and even SMEs engaged in the identification and development of new drugs...

EB - Genetika a molekulární biologie

  • 2013 - 2018
    • •
  • 177 735 tis. Kč
    • •
  • 75 549 tis. Kč
    • •
  • MŠMT
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