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10 (0,154s) •

Project

The influence of grape-vine and technology processing on content of chemoprotective polyphenolic substances in wine. (QD1155)

Study of occurrence of chemoprotective phenolic compounds in wine with view to origin, health and maturity of grapes. Determination of resveratrol concentration as a stressfactor on Botrytis cinerea contamination. Technological realisation o...

GM - Potravinářství

  • 2001 - 2005
    • •
  • 900 tis. Kč
    • •
  • 900 tis. Kč
    • •
  • MZe
Project

Inhibitors of Angiogenesis Design, Synthesis and Biological Exploitation (OC08049)

Flavonolignans silybin and dehydrosilybin, isolated from the seeds of the milk thistle (Silybum marianum) have chemoprotective effects and they act as potent regulators of the cell cycle. New derivatives of silybin will be prepared, e.g for ...

CC - Organická chemie

  • 2008 - 2011
    • •
  • 1 553 tis. Kč
    • •
  • 1 553 tis. Kč
    • •
  • MŠMT
Project

MicroRNAs significance in chemoprotective effects of phytochemicals contained in Brassica vegetables and association of their binding sites polymorphisms with risk of colorectal cancer (NS10352)

Our study is based on the new microRNA-based methodical approach to identification of new genetic factors with potential to attenuate or enhance cancer-preventive effects of Brassica phytochemicals in the human. Laboratory evaluation of these factors...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2009 - 2011
    • •
  • 4 819 tis. Kč
    • •
  • 4 392 tis. Kč
    • •
  • MZ
Project

Plant chemoprotectants - New food supplements for health and prevention of chronic diseases. (FT-TA3/024)

Phytochemical and pharmacological research of the plants Lonicera caerulea, Vaccinium macrocarpon and Boswelia serata, which contain substances with potential chemoprotectivei (anticarcinogenic) effects. The ectracts/fractions/substances (polyphenols...

FR - Farmakologie a lékárnická chemie

  • 2006 - 2010
    • •
  • 24 034 tis. Kč
    • •
  • 10 788 tis. Kč
    • •
  • MPO
Project

Chemoprotective and biological activities of the new dehydro-derivatives of flavonolignans of silymarine. (LD14096)

New preparatory method for multigram amount production of the optically pure starting materials, e.g. silychristin and silydianin will be developed. New methods of mild oxidations of silychristin and silydianin using chemical and chemoenzymatic metho...

CE - Biochemie

  • 2014 - 2016
    • •
  • 2 099 tis. Kč
    • •
  • 2 015 tis. Kč
    • •
  • MŠMT
Project

Anti-inflammatory activity of Macleaya cordata extract and its component in vitro and in vivo (ME10071)

the chemoprotective and/or anti-inflammatory activity of M.c. extract and its main components...

CE - Biochemie

  • 2010 - 2011
    • •
  • 992 tis. Kč
    • •
  • 642 tis. Kč
    • •
  • MŠMT
Project

Enzymatic glycosylation of phenolic and polyphenolic substances. (7AMB13AR005)

The diglycosidase a-rhamnosyl-b-glucosidase from Acremonium and/or from other fungal sources will be purified and characterized from the proteomic point of view. a-Rhamnosidase from fungal producers will be cloned to be used as alternative to the dig...

CE - Biochemie

  • 2013 - 2014
    • •
  • 319 tis. Kč
    • •
  • 319 tis. Kč
    • •
  • MŠMT
Project

Synthesis and Biological Characterization of New Compounds Derived from Silibinin for Potential Use as Chemoprotectants in Dermatology (GA303/02/1097)

This project proposal represents logical extension and continuation of pharmacological studies of silibinin glycosides. The effort is concentrated to the search for potentially useful biological activities of novel derivatives of silibinin and dehydr...

CE - Biochemie

  • 2002 - 2004
    • •
  • 4 207 tis. Kč
    • •
  • 2 905 tis. Kč
    • •
  • GA ČR
Project

Mechanisms of antiradical activity of flavonolignan silybin and preparation of hybrid antioxidant compounds for potential application in medicine (KJB400200701)

their use as chemoprotectants and more effective antioxidants....

CC - Organická chemie

  • 2007 - 2009
    • •
  • 993 tis. Kč
    • •
  • 993 tis. Kč
    • •
  • AV ČR
Project

Modulation of intestinal inflammation and nitric oxide production by quercetin and its conjugates (GAP301/11/0767)

In gastrointestinal tract, nitric oxide (NO) plays an important role in both physiological and pathological processes. Intestinal inflammation is accompanied by overproduction of NO and represents an effective mechanism of host defence against invadi...

CE - Biochemie

  • 2011 - 2014
    • •
  • 7 838 tis. Kč
    • •
  • 7 838 tis. Kč
    • •
  • GA ČR
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