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146 (0,093s) •

Project

HDL and LDL lipoprotein subpopulations and fibrinogen influenced by diet with alcohol (NA6590)

Effect of moderate drinking of Moravian white wine and red wine for 4 weeks on HDL and LDL lipoprotein subpopulations, cholesterol esterification and fibrinogen will be studied in 50 men.......

FQ - Veřejné zdravotnictví, sociální lékařství

  • 2001 - 2003
    • •
  • 1 567 tis. Kč
    • •
  • 1 558 tis. Kč
    • •
  • MZ
Project

LDL gene score in the diagnosis of primary hypercholesterolemias and cardiovascular risk assessment (NV15-28277A)

by mutations in the LDL-receptor gene or the the gene encoding for apolipoprotein B, genetically determined by common variants in several genes modulating plasma cholesterol levels (LDL polygenic score). The phenotype and ...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2015 - 2018
    • •
  • 9 760 tis. Kč
    • •
  • 9 760 tis. Kč
    • •
  • MZ
Project

Proprotein convertase subtilisin/kexin 9 (PCSK9) in the pathophysiology a treatment of dry age-related macular degeneration (NV17-29241A)

of cell surface low density lipoprotein (LDL) cholesterol receptor levels. Decrease that rheohemapheresis also reduces plasma PCSK9 levels by removing LDL cholesterol. The PCSK9 level of LDL receptor func...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2017 - 2020
    • •
  • 9 814 tis. Kč
    • •
  • 9 814 tis. Kč
    • •
  • MZ
Project

Prediction, optimation and individualization of therapeutic procedure in LDL-apheresis - a multivariate model in a prospective study. (NB7006)

The project objectives are to define the most important factors influencing the speed and economy of LDL-aphereses, therapeutic results (substantial reduction of LDL-cholesterol) under conditions of minimal patient´s discom...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2002 - 2004
    • •
  • 1 493 tis. Kč
    • •
  • 1 490 tis. Kč
    • •
  • MZ
Project

Study of atherogenic mechanisms during treatment with LDL-apheresis the role of fatty acid metabolism, cholesterol synthesis and lipoperoxidation (NB6822)

) lipoperoxidation processes and antioxidant consumption, iii) cholesterol biosynthetic pathway...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2001 - 2003
    • •
  • 1 841 tis. Kč
    • •
  • 1 839 tis. Kč
    • •
  • MZ
Project

Cyklosporin in renal transplantation a risk factor for lipid matabolism (IZ3065)

FP - Ostatní lékařské obory

  • 1995 - 1997
    • •
  • 530 tis. Kč
    • •
  • 499 tis. Kč
    • •
  • MZ
Project

The role of dietary cholesterol in regulation of gene expression in the model of dietary induced hypercholesterolemia (NR9401)

) rat. Themechanism of increase in cholesterol concentration in VLDL, IDL, and LDL after dietary cholesterol load will be studied in experimental model of diet inducedThe expression of genes that respond to dietary chol...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2009
    • •
  • 4 928 tis. Kč
    • •
  • 4 857 tis. Kč
    • •
  • MZ
Project

Phenotype Genotype Correlation in Children and Adolescents with Heterozygous Familial Hypercholesterolemia (NA7452)

for apoB, LDL-cholest.receptors, apoE allels. Phenotype will be characterized by lipid spectrum, metabolites of endogenous cholest.synthesis, individual cholesterol tolerance or drug treatment. The goal: to detect the frequency of ...

FG - Pediatrie

  • 2003 - 2005
    • •
  • 5 429 tis. Kč
    • •
  • 4 635 tis. Kč
    • •
  • MZ
Project

The role of metabolic, thrombocytic and endothelial dysfunction in process of atherogenesis (NB6549)

will be the confirmation if and how much the quick and deep drop of cholesterol after LDL-apheresisThe aim of the study is to optimalize the therapeutical procedure in cases of severe familial hyperlipoproteinaimia treated with ext...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2001 - 2003
    • •
  • 1 459 tis. Kč
    • •
  • 1 459 tis. Kč
    • •
  • MZ
Project

A-204C polymorphism and regulation of cholesterol 7alpha-hydroxylase activity (NR8987)

Circadian variation in cholesterol 7alpha-hydroxylase (CYP7A1) activity will be studied in healthy volunteers homozygous either for -204A or -204C variant in CYP7A1 gene promoter. Circadian variation in CYP7A1 activity will be studied under ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2006 - 2008
    • •
  • 3 917 tis. Kč
    • •
  • 3 599 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 146